Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis

Bai, Qiaoyun; Piao, Yihua; Zhou, Xiaofang; Piao, Qinji; Jiang, Jingzhi; Liu, Hanye; Piao, Hongmei; Li, Liangchang; Song, Yang; Yan, Guanghai

doi:10.1021/acs.jafc.1c07877

Cited by 20 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disorder of the redox system and inflammation can promote apoptosis [ 114 , 115 ]. In this study, colonic epithelial cells of mice showed mitochondrial damage after PP-MP exposure, and TUNEL results suggested apoptosis of colonic epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Polypropylene Microplastics via Oral Ingestion Induces Colonic Apoptosis and Intestinal Barrier Damage through Oxidative Stress and Inflammation in Mice

Jia

Han²,

Liu³

et al. 2023

Toxics

View full text Add to dashboard Cite

Extensive environmental pollution by microplastics has increased the risk of human exposure to plastics. However, the biosafety of polypropylene microplastics (PP-MPs), especially of PP particles < 10 μm, in mammals has not been studied. Thus, here, we explored the mechanism of action and effect of exposure to small and large PP-MPs, via oral ingestion, on the mouse intestinal tract. Male C57BL/6 mice were administered PP suspensions (8 and 70 μm; 0.1, 1.0, and 10 mg/mL) for 28 days. PP-MP treatment resulted in inflammatory pathological damage, ultrastructural changes in intestinal epithelial cells, imbalance of the redox system, and inflammatory reactions in the colon. Additionally, we observed damage to the tight junctions of the colon and decreased intestinal mucus secretion and ion transporter expression. Further, the apoptotic rate of colonic cells significantly increased after PP-MP treatment. The expression of pro-inflammatory and pro-apoptosis proteins significantly increased in colon tissue, while the expression of anti-inflammatory and anti-apoptosis proteins significantly decreased. In summary, this study demonstrates that PP-MPs induce colonic apoptosis and intestinal barrier damage through oxidative stress and activation of the TLR4/NF-κB inflammatory signal pathway in mice, which provides new insights into the toxicity of MPs in mammals.

show abstract

Section: Discussionmentioning

confidence: 99%

Exposure to Polypropylene Microplastics via Oral Ingestion Induces Colonic Apoptosis and Intestinal Barrier Damage through Oxidative Stress and Inflammation in Mice

Jia

Han²,

Liu³

et al. 2023

Toxics

View full text Add to dashboard Cite

show abstract

“…[77,78] Sesamin (NuBBE ID: 1416) has been studied in treating asthma, Parkinson's and Alzheimer's diseases, and several types of cancers, including breast, cervical, gallbladder and colon cancer. [79][80][81][82][83][84][85] In drug discovery and development process pharmacokinetics plays a vital role to explore lead compounds through optimizing their ADMET properties. In order to pass clinical trials subsequently the final approval of drug candidate, pharmacokinetic properties of the drug candidate and pharmacological action on the body, organ and tissue must be determined.…”

Section: Discussionmentioning

confidence: 99%

“…Asaranin (NuBBE ID: 1420) has been previously reported to have anticancer effects against ovarian cancer and act as an immunomodulatory [77,78] . Sesamin (NuBBE ID: 1416) has been studied in treating asthma, Parkinson's and Alzheimer's diseases, and several types of cancers, including breast, cervical, gallbladder and colon cancer [79–85] …”

Section: Discussionmentioning

confidence: 99%

Amazon Plant‐Derived Compounds Suppressing Dengue NS5 Protein: Insights from Computational Drug Development and Network Pharmacology Approach

Ahmed,

Bari,

Biswas

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Dengue, a life‐threatening Flavivirus infection, is rampant across 128 tropical and subtropical regions, annually afflicting millions and causing 20,000 deaths due to inadequate treatments. Despite the FDA‐approved Dengvaxia vaccine, its limitations necessitate novel drug development. Notably, the enzymatic nature of the NS5 protein (PDB ID: 3p97) within DENV, responsible for viral RNA synthesis, makes it a prime drug target. Employing Pharmacoinformatics, Molecular Dynamics Simulations, Quantum Mechanics, and network pharmacology, we screened compounds from NuBBE, the Brazilian Amazon Plant Database, along with reported dengue compounds. Docking yielded promising scores (−11.1 to −2.8) and (−11 to −3.1) kcal/mol, respectively. From 1310 phytochemicals, top compounds emerged: Ramosin, Pectolinarin, hinokinin, and sesamin, boasting scores of −11, −11, −9.7, and −9.6, surpassing Acetaminophen's −5.8. Validated post‐docking interactions used 100 ns Molecular Dynamics Simulations and quantum mechanics. Pharmacokinetics and Toxicity analysis aligned with ADME norms, showing no undue toxicity. Network pharmacology unveiled connections between bioactive chemicals and disease targets. This investigation uncovers the potential of these compounds to inhibit DENV‐3 NS5 protein. In vitro, in vivo, and cell line assays are crucial next steps for specific anti‐dengue drug development.

show abstract

“…However, several studies have found that excessive mitochondrial autophagy promotes the development of in ammatory diseases [54] . For example, Bai [55] et al reported that sesamin alleviated asthma by inhibiting mitophagy and mitochondrial apoptosis. In addition, chronic CS exposure has been reported to induce mitochondrial autophagy, leading to the accumulation of nuclear mitochondria in human lung epithelial cells and broblasts [56] .…”

Section: Discussionmentioning

confidence: 99%

Yunyao Qilongtian alleviates the progression of COPD by regulating HMGB1 and inhibiting AMPK/mTOR/ULK1 pathway induced mitophagy

Yang

Liu

Jing

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Qilongtian is a traditional Chinese medicine compound with Yunnan medical characteristics. Its main components have the effect of inhibiting inflammation. Inflammatory response is closely related to the progression of Chronic obstructive pulmonary disease (COPD). Therefore, this study is mainly to confirm the influence and mechanism of Yunyao Qilongtian on pulmonary phlogosis and airway remodeling with COPD in patients. Methods: In this study, using Wright Giemsa staining to measure the number of neutrophils in bronchoalveolar lavage fluid (BALF). Through ELISA assay, IL-β, IL-6 and TNF-α were detected in BALF. Expect that, we used HE staining to detect the Lung histological changes. Collagen deposition in or near the trachea was detected by Masson staining. Through Western blot assay, the proteins of the Mitochondrial autophagy and AMPK/mTOR/ULK1 signaling pathway were detected. The level of HMGB1, 8-OHdG and 4-HNE was detected by immunohistochemistry. Mitochondrial autophagy was detected by LC3 and MTR double immunostaining. Membrane potential was measured by JC-1staining. MitoSOX evaluates the production of mtROS. Cx I, II, III, and IV activity assay kit assay for the activity. ATP concentration was detected by ATP detection kit. Results: Qilongtian significantly attenuated cigarette smoke (CS) -induced lung inflammation and airway remodeling, as well as the mitophagy and mitochondrial dysfunction of CS-induced. Qilongtian alleviated CS-induced HMGB1 upregulation. Overexpression of HMGB1 partially restored the protective effect of Qilongtian on lung inflammation and airway remodeling in COPD. As an inhibitor of the AMPK/mTOR/ULK1 pathway, AMPKi could partially restored the influence of OE-HMGB1. Conclusion: Yunyao Qilongtian alleviates COPD lung inflammation and airway remodeling by inhibiting HMGB1 to inhibit excessive mitochondrial autophagy induced by AMPK/mTOR/ULK1 signaling pathway.

show abstract

Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis

Cited by 20 publications

References 41 publications

Exposure to Polypropylene Microplastics via Oral Ingestion Induces Colonic Apoptosis and Intestinal Barrier Damage through Oxidative Stress and Inflammation in Mice

Exposure to Polypropylene Microplastics via Oral Ingestion Induces Colonic Apoptosis and Intestinal Barrier Damage through Oxidative Stress and Inflammation in Mice

Amazon Plant‐Derived Compounds Suppressing Dengue NS5 Protein: Insights from Computational Drug Development and Network Pharmacology Approach

Yunyao Qilongtian alleviates the progression of COPD by regulating HMGB1 and inhibiting AMPK/mTOR/ULK1 pathway induced mitophagy

Contact Info

Product

Resources

About