Sesamin Attenuates Obesity-Associated Nonalcoholic Steatohepatitis in High-Fat and High-Fructose Diet-Fed Mice

Yang, Yang; Yu, Jing; Huo, Jiayao; Yan, Yaping

doi:10.1089/jmf.2022.k.0091

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…Interestingly, both our present study and others suggest that Ses reduces elevated liver enzymes in NAFLD/NASH, indicating its potential role in improving liver cell damage ( Zhang et al, 2016 ; Yang et al, 2023 ). However, the liver-protective effects of Ses are related to its ability to inhibit lipid metabolism and the overproduction of reactive oxygen species ( Zhang et al, 2016 ; Yang et al, 2023 ). The direct effect of Ses on improving NASH-induced liver cell damage has not been fully elucidated.…”

Section: Discussionsupporting

confidence: 73%

“…Ses is a natural lignan found in sesame oil and seeds. Ses has been shown to possess liver-protective properties, effectively improving hepatic damage in mice with high-fat and high-fructose diet-induced NASH and rats with high-fat diet-induced NAFLD ( Zhang et al, 2016 ; Yang et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…Sesamin (Ses), a natural lignan found in sesame and sesame oil, possesses various pharmacological properties, including lipid-lowering, liver-protective, antihypertensive and antitumor effects ( Li et al, 2013 ; Majdalawieh et al, 2020 ; Wen et al, 2022 ; Yang et al, 2023 ). Additionally, Ses has been shown to reduce the production of the pro-inflammatory cytokine interleukin (IL)-1β both in vivo and in vitro ( Phitak et al, 2012 ; Chiang et al, 2014 ; Fanhchaksai et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Sesamin ameliorates nonalcoholic steatohepatitis through inhibiting hepatocyte pyroptosis in vivo and in vitro

Zhang,

Zhou,

Zhang

et al. 2024

Front. Pharmacol.

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Sesamin (Ses) is a natural lignan abundantly present in sesame and sesame oil. Pyroptosis, a newly identified type of pro-inflammatory programmed necrosis, contributes to the development of non-alcoholic steatohepatitis (NASH) when hepatocyte pyroptosis is excessive. In this study, Ses treatment demonstrated an improvement in hepatic damage in mice with high-fat, high-cholesterol diet-induced NASH and palmitate (PA)-treated mouse primary hepatocytes. Notably, we discovered, for the first time, that Ses could alleviate hepatocyte pyroptosis both in vivo and in vitro. Furthermore, treatment with phorbol myristate acetate, a protein kinase Cδ (PKCδ) agonist, increased PKCδ phosphorylation and attenuated the protective effects of Ses against pyroptosis in PA-treated mouse primary hepatocytes. Mechanistically, Ses treatment alleviated hepatocyte pyroptosis in NASH, which was associated with the regulation of the PKCδ/nod-like receptor family CARD domain-containing protein 4/caspase-1 axis. This study introduces a novel concept and target, suggesting the potential use of functional factors in food to alleviate liver damage caused by NASH.

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