Sesamin mitigates lead-induced behavioral deficits in male rats: The role of oxidative stress

Ghaderi, Shahab; Rashno, Masome; Sarkaki, Alireza; Khoshnam, Seyed Esmaeil

doi:10.1016/j.brainresbull.2023.110852

Cited by 4 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, SEL has been shown to reduce levels of reactive oxygen species and malondialdehyde and increase superoxide dismutase activity in the liver of mice exposed to a high-fat diet and physical activity (Tian et al, 2023). In a study, it has been reported that there is a negative correlation between oxidative stress factors and cognitive memory (S. Ghaderi et al, 2024). Studies have shown that neuroinflammation and the production of free radicals can lead to the destruction of neurons (Mancuso et al, 2007) and disruption in synaptic plasticity , as the cellular basis of memory and learning, resulting in behavioral disorders.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of selegiline against amyloid beta‐induced anxiety‐like behavior and memory impairment

Mohamadpour,

Mirazi,

Komaki

et al. 2024

Brain and Behavior

View full text Add to dashboard Cite

BackgroundAlzheimer's disease (AD) is a complex and common neurodegenerative disorder. The present study aimed to investigate the potential effects of selegiline (SEL) on various aspects of memory performance, anxiety, and oxidative stress in an AD rat model induced by intracerebroventricular injection of amyloid beta1‐42 (Aβ1‐42).MethodsOral administration of SEL at a dose of 0.5 mg/kg/day was performed for 30 consecutive days. Following the 30 days, several tests, including the open‐field, elevated plus‐maze, novel object recognition, Morris water maze, and passive avoidance learning were conducted to assess locomotor activity, anxiety‐like behavior, recognition memory, spatial memory, and passive avoidance memory, respectively.ResultsThe results indicate that the induction of AD in rats led to recognition memory, spatial memory, and passive avoidance memory impairments, as well as increased anxiety. Additionally, the AD rats exhibited a decrease in total antioxidant capacity and an increase in total oxidant status levels, suggesting an imbalance in oxidative‐antioxidant status. However, the administration of SEL improved memory performance, reduced anxiety, and modulated oxidative‐antioxidant status in AD rats.ConclusionsThese findings provide evidence that SEL may alleviate anxiety‐like behavior and cognitive deficits induced by Aβ through modulation of oxidative‐antioxidant status.

show abstract

Section: Discussionmentioning

confidence: 99%