Sesamin Protects against and Ameliorates Rat Intestinal Ischemia/Reperfusion Injury with Involvement of Activating Nrf2/HO‐1/NQO1 Signaling Pathway

Wang, Yilin; Wen, Jing; Almoiliqy, Marwan; Wang, Yaojia; Liu, Zhihao; Yang, Xiaobo; Lu, Xiao‐Long; Meng, Qiang; Peng, Jinyong; Lin, Yuan; Sun, Pengyuan

doi:10.1155/2021/5147069

Cited by 30 publications

(17 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nrf2 controls the expression of a series of antioxidant genes and is the core factor in regulating antioxidant stress [ 14 ]. It has been proved that Nrf2 can enhance the antioxidant capacity of cells by upregulating the expression of detoxification enzyme genes such as NAD(P)H, quinone oxidoreductase (NQO1), and heme oxidase-1(HO-1) [ 15 , 16 ]. The protective effect of Nrf2 on the heart has also been confirmed in many animal models, including uncompensated cardiac remodeling and cardiac dysfunction caused by aortic arch constriction (TAC), ventricular remodeling, and cardiac dysfunction caused by myocardial infarction, etc.…”

Section: Discussionmentioning

confidence: 99%

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

et al. 2023

View full text Add to dashboard Cite

Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury. C57BL/6J mice were intraperitoneally injected with 20 mg/Kg DOX to induce heart injury. After 3 days, the cardiac function, cardiac histopathology, myocardial apoptosis, and the expression level of NSUN2 were detected. In vitro, H9C2 cells were transfected with NSUN2 siRNA or overexpressed lentivirus and then treated with 500 ng/ml DOX. After 24 h, the changes in reactive oxygen species (ROS), apoptosis, and NSUN2 expression were detected. After DOX treatment, both in vitro and in vivo experiments showed that the cardiac function decreased, the number of apoptotic cells increased, and the expression level of NSUN2 increased. Interfering the expression of NSUN2 by siRNA promoted DOX-induced heart injury, while overexpression of NSUN2 could inhibit DOX-induced heart injury. Further study showed that NSUN2 promoted antioxidative stress by upregulating the Nrf2 protein level. In addition, NSUN2 overexpression could increase the half-life of Nrf2 mRNA. m5C RNA methylation immunoprecipitation (MeRIP) also showed that the level of Nrf2 m5C mRNA was significantly increased in NSUN2 overexpressed group when compared to the GFP group. NSUN2 enhances the expression of Nrf2 by promoting Nrf2 mRNA m5C modification and enhances its antioxidative stress effect to alleviate DOX-induced myocardial injury.

show abstract

Section: Discussionmentioning

confidence: 99%

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

et al. 2023

View full text Add to dashboard Cite

show abstract

“…AKG via glutamine production can alleviate ROS stress in cells. In the intestinal cells, glutamine can elevate glutathione concentrations [ 68 , 69 ]. Glutathione is one of the most potent ROS scavengers, reducing ROS during self-oxidation [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

“…Glutathione is one of the most potent ROS scavengers, reducing ROS during self-oxidation [ 70 ]. Moreover, glutamine can activate the NRF2/ARE signaling pathway and increase NRF2 gene expression [ 69 , 71 ]. SOD and CAT levels increased in murine liver due to the upregulation of NRF2 [ 72 ], conferring better protection against ROS damage.…”

Section: Discussionmentioning

confidence: 99%

Effects of In Ovo Injection of α-Ketoglutaric Acid on Hatchability, Growth, Plasma Metabolites, and Antioxidant Status of Broilers

Gupta

Ncho²,

Goel³

et al. 2022

Antioxidants

View full text Add to dashboard Cite

Recently, α-ketoglutaric acid (AKG) has gained importance as an antioxidant. Its dietary supplementation in animals and humans has proved beneficial. Moreover, an extensive group of studies on in ovo feeding has proved that it produces better day-old chicks and overall performance. Combining the two, we hypothesized that in ovo feeding of AKG could improve the antioxidant status in addition to chick quality and broiler performance. At 17.5 days of incubation, eggs were divided into one of five groups: eggs that received (i) no injection (U-CON), (ii) distilled water (DDW) only (0 AKG), (iii) 0.5% AKG dissolved in DDW (0.5 AKG), (iv) 1.0% AKG dissolved in DDW (1.0 AKG), or (v) 1.5% AKG dissolved in DDW (1.5 AKG). Chicks were raised until 21 days of age. Biological samples were collected on day 0 and day 21. Body weight (p = 0.020), average daily gain (p = 0.025), and average daily feed intake (p = 0.036) were found to quadratically increase with the amount of AKG during the grower phase. At day 0, the absolute (p = 0.040) and relative weight (p = 0.035) of the liver increased linearly with an increasing amount of AKG. The 0.5 AKG group had significantly higher plasma protein (p = 0.025), absolute and relative heart indices at day 0 (p = 0.006). An in ovo feeding of AKG improved the plasma antioxidant capacity of chicks at day 0 as compared to 0 AKG. AKG effect was seen on the plasma antioxidant balance, which increased linearly with the increasing dose of in ovo AKG. Furthermore, 1.0 AKG and 1.5 AKG showed a significant (p = 0.002) upregulation of the hepatic mRNA expression of nuclear factor erythroid 2-related factor (NRF2) in comparison to 0 AKG. The results imply that without negatively affecting hatchability performance, in ovo feeding of AKG has beneficial effects on the antioxidant status of broilers.

show abstract

“…Sesamin, a naturally occurring lignin compound, is isolated from sesame seeds and has many positive health effects, including anti-inflammatory, anticancer, anti-hypertension, anti-thrombotic, antidiabetic, anti-atherogenic, anti-obesity, and lipolytic effects ( Dalibalta et al, 2020 ). It also can reduce damage to the intestine, kidneys, heart, brain, and liver ( Wang et al, 2021b ). Studies have shown that sesamin inhibits LPS-induced macrophage-derived chemokine expression through ER, PPAR-α, MAPK-p38 pathway, NFκB-p65 pathway, and epigenetic regulation ( Hsieh et al, 2014 ).…”

Section: Antiatherosclerotic Herbal Medicine Potentially Targeting Tr...mentioning

confidence: 99%

Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

Wang

Liu²,

Hu³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Atherosclerosis (AS) is the pathology of atherosclerotic cardiovascular diseases (ASCVD), characterized by persistent chronic inflammation in the vessel wall, in which monocytes/macrophages play a key role. It has been reported that innate immune system cells can assume a persistent proinflammatory state after short stimulation with endogenous atherogenic stimuli. The pathogenesis of AS can be influenced by this persistent hyperactivation of the innate immune system, which is termed trained immunity. Trained immunity has also been implicated as a key pathological mechanism, leading to persistent chronic inflammation in AS. Trained immunity is mediated via epigenetic and metabolic reprogramming and occurs in mature innate immune cells and their bone marrow progenitors. Natural products are promising candidates for novel pharmacological agents that can be used to prevent or treat cardiovascular diseases (CVD). A variety of natural products and agents exhibiting antiatherosclerotic abilities have been reported to potentially interfere with the pharmacological targets of trained immunity. This review describes in as much detail as possible the mechanisms involved in trained immunity and how phytochemicals of this process inhibit AS by affecting trained monocytes/macrophages.

show abstract

Sesamin Protects against and Ameliorates Rat Intestinal Ischemia/Reperfusion Injury with Involvement of Activating Nrf2/HO‐1/NQO1 Signaling Pathway

Cited by 30 publications

References 84 publications

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Effects of In Ovo Injection of α-Ketoglutaric Acid on Hatchability, Growth, Plasma Metabolites, and Antioxidant Status of Broilers

Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

Contact Info

Product

Resources

About