Sesamol incorporated cellulose acetate-zein composite nanofiber membrane: An efficient strategy to accelerate diabetic wound healing

Liu, Fuguo; Li, Xingze; Wang, Lin; Yan, Xiaojia; Ma, Dexue; Liu, Zhigang; Liu, Xuebo

doi:10.1016/j.ijbiomac.2020.01.277

Cited by 87 publications

(30 citation statements)

References 30 publications

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“…Among the components of sesame potentially responsible for the wound healing effect, sesamol was most often studied (e.g., [350]). Composite cellulose acetate-protein membranes impregnated with sesamol were recently designed for the acceleration of wound healing [351]. Membranes loaded with 5% sesamol promoted wound healing and inhibited wound inflammation in diabetic mouse.…”

Section: Pain Relieve Anti Inflammatory Effects and Wound Healingmentioning

confidence: 99%

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

et al. 2021

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Major lignans of sesame sesamin and sesamolin are benzodioxol--substituted furofurans. Sesamol, sesaminol, its epimers, and episesamin are transformation products found in processed products. Synthetic routes to all lignans are known but only sesamol is synthesized industrially. Biosynthesis of furofuran lignans begins with the dimerization of coniferyl alcohol, followed by the formation of dioxoles, oxidation, and glycosylation. Most genes of the lignan pathway in sesame have been identified but the inheritance of lignan content is poorly understood. Health-promoting properties make lignans attractive components of functional food. Lignans enhance the efficiency of insecticides and possess antifeedant activity, but their biological function in plants remains hypothetical. In this work, extensive literature including historical texts is reviewed, controversial issues are critically examined, and errors perpetuated in literature are corrected. The following aspects are covered: chemical properties and transformations of lignans; analysis, purification, and total synthesis; occurrence in Seseamum indicum and related plants; biosynthesis and genetics; biological activities; health-promoting properties; and biological functions. Finally, the improvement of lignan content in sesame seeds by breeding and biotechnology and the potential of hairy roots for manufacturing lignans in vitro are outlined.

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Section: Pain Relieve Anti Inflammatory Effects and Wound Healingmentioning

confidence: 99%

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

et al. 2021

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“…Sesamol, one of the phenolic compounds of a sesame seed, was loaded into CA-zein composite NF that resulted in accelerated reepithelization and improvement in DW healing [164].…”

Section: Cellulose-based Matsmentioning

confidence: 99%

Nanofiber-based systems intended for diabetes

et al. 2021

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Diabetic mellitus (DM) is the most communal metabolic disease resulting from a defect in insulin secretion, causing hyperglycemia by promoting the progressive destruction of pancreatic β cells. This autoimmune disease causes many severe disorders leading to organ failure, lower extremity amputations, and ultimately death. Modern delivery systems e.g., nanofiber (NF)-based systems fabricated by natural and synthetic or both materials to deliver therapeutics agents and cells, could be the harbinger of a new era to obviate DM complications. Such delivery systems can effectively deliver macromolecules (insulin) and small molecules. Besides, NF scaffolds can provide an ideal microenvironment to cell therapy for pancreatic β cell transplantation and pancreatic tissue engineering. Numerous studies indicated the potential usage of therapeutics/cells-incorporated NF mats to proliferate/regenerate/remodeling the structural and functional properties of diabetic skin ulcers. Thus, we intended to discuss the aforementioned features of the NF system for DM complications in detail. Graphic abstract

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“…The wounds in groups L and H were similar to those in group C, and essentially had healed on d 9. Studies have shown that sesamol can down-regulate expression of inflammatory factors such as IL-1β, and TNF-α, while up-regulating expression of IL-6 (anti-inflammatory factor), which can promote the rapid healing of diabetic wounds [83].…”

Section: Drugs/natural Polymer Electrospun Fibersmentioning

confidence: 99%

Application of Electrospun Nanofiber Membrane in the Treatment of Diabetic Wounds

et al. 2021

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Diabetic wounds are complications of diabetes which are caused by skin dystrophy because of local ischemia and hypoxia. Diabetes causes wounds in a pathological state of inflammation, resulting in delayed wound healing. The structure of electrospun nanofibers is similar to that of the extracellular matrix (ECM), which is conducive to the attachment, growth, and migration of fibroblasts, thus favoring the formation of new skin tissue at the wound. The composition and size of electrospun nanofiber membranes can be easily adjusted, and the controlled release of loaded drugs can be realized by regulating the fiber structure. The porous structure of the fiber membrane is beneficial to gas exchange and exudate absorption at the wound, and the fiber surface can be easily modified to give it function. Electrospun fibers can be used as wound dressing and have great application potential in the treatment of diabetic wounds. In this study, the applications of polymer electrospun fibers, nanoparticle-loaded electrospun fibers, drug-loaded electrospun fibers, and cell-loaded electrospun fibers, in the treatment of diabetic wounds were reviewed, and provide new ideas for the effective treatment of diabetic wounds.

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Sesamol incorporated cellulose acetate-zein composite nanofiber membrane: An efficient strategy to accelerate diabetic wound healing

Cited by 87 publications

References 30 publications

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

Nanofiber-based systems intended for diabetes

Application of Electrospun Nanofiber Membrane in the Treatment of Diabetic Wounds

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