2021
DOI: 10.1128/mbio.00591-21
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Sesbanimide R, a Novel Cytotoxic Polyketide Produced by Magnetotactic Bacteria

Abstract: Genomic information from various magnetotactic bacteria suggested that besides their common ability to form magnetosomes, they potentially also represent a source of bioactive natural products. By using targeted deletion and transcriptional activation, we connected a large biosynthetic gene cluster (BGC) of the trans-acyltransferase polyketide synthase (trans-AT PKS) type to the biosynthesis of a novel polyketide in the alphaproteobacterium Magnetospirillum gryphiswaldense. Structure elucidation by mass spectr… Show more

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Cited by 4 publications
(7 citation statements)
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“…Glutarimide antibiotics characterized by a glutarimide ring were derived mainly from Streptomyces in the past but were recently found in various strains, including Burkholderia, Pseudomonas, and other marine-derived strains [9][10][11][12][13]. These compounds exhibit widespread pharmacological effects, such as antitumor, anti-inflammatory, and antifungal.…”
Section: Discussionmentioning
confidence: 99%
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“…Glutarimide antibiotics characterized by a glutarimide ring were derived mainly from Streptomyces in the past but were recently found in various strains, including Burkholderia, Pseudomonas, and other marine-derived strains [9][10][11][12][13]. These compounds exhibit widespread pharmacological effects, such as antitumor, anti-inflammatory, and antifungal.…”
Section: Discussionmentioning
confidence: 99%
“…Compounds 1 and 2 were determined to be gladiofungin A (or gladiostatin) and its degradation product, named gladiofungin C, via a comparison of its 1 H and 13 was connected to C-18 (δ H/C 2.33/33.9), supported by the HMBC correlation between H-18 and C-19 (Figures 2c and 3). Gladiofungin E (4) and gladiofungin F (5) were isolated as colorless oils.…”
Section: Structural Elucidation and Bioactivities Assay Of Compounds 1-7mentioning
confidence: 92%
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