SESN2 correlates with advantageous prognosis in hepatocellular carcinoma

Chen, Shaosen; Yan, Weigang; Lang, Weiya; Yu, Jing; Xu, Li; Xu, Xinyu; Liu, Yunlong; Bao, Hongchu

doi:10.1186/s13000-016-0591-2

Cited by 18 publications

(19 citation statements)

References 30 publications

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“…In the present study, sestrin2 was found to be downregulated in 55% of SGC cases relative to non-cancerous and adjacent normal skin. The above data are consistent with the previous studies where differential sestrin2 expression has been detected in cancerous and non-cancerous tissue samples of patients with hepatocellular carcinoma 11. Reduced protein expression of sestrin2 was significantly correlated with poor tumour differentiation and upper eyelid involvement.…”

Section: Discussionsupporting

confidence: 92%

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Immunohistochemical evaluation of stress-responsive protein sestrin2 and its correlation with p53 mutational status in eyelid sebaceous gland carcinoma

et al. 2018

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Section: Discussionsupporting

confidence: 92%

“…The immunohistochemical staining results for p53 and SESN2 were evaluated on the basis of both percentage positivity and staining intensity 11. The percentage of immunostaining was based on the number of tumour cells showing positivity in 10 high power fields.…”

Section: Methodsmentioning

confidence: 99%

Immunohistochemical evaluation of stress-responsive protein sestrin2 and its correlation with p53 mutational status in eyelid sebaceous gland carcinoma

et al. 2018

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“…SESNs have also been reported to regulate the AMPK/mTOR complex 1 signaling pathway, which is involved in cellular autophagy (56,57). Our study detected decreased expression levels of SESN2 in liver cancer tissues compared with paracancerous tissues (58), which provided clinical evidence that muscone may inhibit tumor development.…”

Section: Discussionsupporting

confidence: 66%

Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy

Yang

et al. 2020

Oncol Rep

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Traditionally, musk has been used as an analgesic to treat pain associated with cancer. Hepatocellular carcinoma (HCC) is an aggressive tumor; however, patients with liver cancer that received musk were reported to live longer and have a higher quality of life. Thus, the present study aimed to investigate whether muscone, a macrocyclic compound of musk, demonstrated potential as an anti-liver cancer drug for the non-surgical treatment of advanced liver cancer. Briefly, liver cancer cells were treated with muscone and the rates of cellular apoptosis and autophagy were investigated using staining techniques and western blotting. The underlying molecular mechanisms of muscone were evaluated using high-throughput sequencing and the in vitro effects of muscone were subsequently validated in vivo using a nude mouse model. Muscone increased the rates of apoptosis and autophagy in liver cancer cells; the increase in cellular apoptosis was observed to occur through endoplasmic reticulum stress responses, whereas muscone-induced autophagy was closely associated with the AMP kinase/mTOR complex 1 signaling pathway. These findings were verified in vivo. Notably, sestrin-2 expression levels were also significantly decreased in liver cancer tissues compared with paracancerous tissues. In conclusion, the present study suggests that muscone demonstrates potential as an anticancer drug, and the findings of the present study provide the basis for the development of effective anticancer drugs derived from natural compounds.

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“…In certain types of cancers, SESN2 has shown an important role in being pointed out as a tumor suppressor in lung tumors (19), and the decrease in SESN2 expression has also been correlated with a worse prognosis in liver tumors (20) and the induction of its expression restores apoptotic control in head and neck cell models (21).…”

Section: Discussionmentioning

confidence: 99%

Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of SESN2 Have a Role in Age-related Different Prognoses?

Almeida

Souza

Amorim

et al. 2020

Cancer Genomics Proteomics

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Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ≥45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age. Patients and Methods: In order to search and compare genomic alterations that may be related to age, we evaluated the occurrence of CNAs in the genome of 24 PTC samples, divided in two groups (<45 and ≥45 years old). Results: We identified only one region showing a statistically significant difference between the groups (p=0.00357): a deletion of approximately 537 kps in 1p35.3., which was more frequent in patients aged 45 years or older. This is the region where, among others, the gene SESN2 is located, which is activated under oxidative stress and plays an antioxidant role, in addition to protecting the genetic material from damage generated by reactive oxygen species (ROS). Conclusion: This is the first time that a CNA involving the deletion of the SESN2 gene is associated with papillary thyroid carcinomas, particularly in patients aged 45 years and older, indicating that this deletion would lead to a more malignant and prominent tumoral behavior associated to a worst prognosis. Thyroid cancer (TC) is the most common malignancy of the endocrine system, corresponding to 3.4% of all cancers diagnosed annually worldwide. TC is a unique human tumor, with peculiar biological behavior. This is the only tumor for which age is an important prognostic factor (1). Additionally, TC affects more frequently women than men. There are five main histological types of TCs: papillary, follicular (which are considered differentiated), poorly differentiated, anaplastic, and medullary TC (2, 3). Of these, papillary thyroid cancer (PTC) is the most frequent among the thyroid neoplasias, representing around 80-85% of cancers affecting this gland (4, 5). PTCs are characterized by presenting a good prognosis, with survival rates of 90% for 10 years, and show several subtypes, of which the classical variant is the most frequent (6). Among the prognostic factors for PTC, the age of patients is a crucial criterion, because individuals between 20-44 years old present tumors with different behavior when compared to the ones observed in patients older than 45 years (7). Generally, the disease is more aggressive in the second group, with a gradual increase of mortality rates and 643 This article is freely accessible online.

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SESN2 correlates with advantageous prognosis in hepatocellular carcinoma

Cited by 18 publications

References 30 publications

Immunohistochemical evaluation of stress-responsive protein sestrin2 and its correlation with p53 mutational status in eyelid sebaceous gland carcinoma

Immunohistochemical evaluation of stress-responsive protein sestrin2 and its correlation with p53 mutational status in eyelid sebaceous gland carcinoma

Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy

Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of SESN2 Have a Role in Age-related Different Prognoses?

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