Sesquicentennial of the Ophthalmoscope

Ravin, James G.

doi:10.1001/archopht.117.12.1634

Cited by 11 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Helmholtz overcame this problem by using a transparent mirror made of three thin parallel sheets of glass angled to reflect the maximum light in the eye [1]. This first ophthalmoscope proved to be difficult to use and was soon replaced by a concave mirror with a central opening [2]. This invention revolutionized ophthalmology and nowadays funduscopy is one of its most commonly used diagnostic tools.…”

Section: Introductionmentioning

confidence: 99%

Funduscopy in Adult Zebrafish and Its Application to Isolate Mutant Strains with Ocular Defects

et al. 2010

View full text Add to dashboard Cite

Funduscopy is one of the most commonly used diagnostic tools in the ophthalmic practice, allowing for a ready assessment of pathological changes in the retinal vasculature and the outer retina. This non-invasive technique has so far been rarely used in animal model for ophthalmic diseases, albeit its potential as a screening assay in genetic screens. The zebrafish (Danio rerio) is well suited for such genetic screens for ocular alterations. Therefore we developed funduscopy in adult zebrafish and employed it as a screening tool to find alterations in the anterior segment and the fundus of the eye of genetically modified adult animals.A stereomicroscope with coaxial reflected light illumination was used to obtain fundus color images of the zebrafish. In order to find lens and retinal alterations, a pilot screen of 299 families of the F3 generation of ENU-treated adult zebrafish was carried out.Images of the fundus of the eye and the anterior segment can be rapidly obtained and be used to identify alterations in genetically modified animals. A number of putative mutants with cataracts, defects in the cornea, eye pigmentation, ocular vessels and retina were identified. This easily implemented method can also be used to obtain fundus images from rodent retinas.In summary, we present funduscopy as a valuable tool to analyse ocular abnormalities in adult zebrafish and other small animal models. A proof of principle screen identified a number of putative mutants, making funduscopy based screens in zebrafish feasible.

show abstract

Section: Introductionmentioning

confidence: 99%

Funduscopy in Adult Zebrafish and Its Application to Isolate Mutant Strains with Ocular Defects

et al. 2010

View full text Add to dashboard Cite

show abstract

“…There he had two rooms which he rented from a man's tailor C. F. Groth. 19,20 In 1852 the clinic is moved to Karlstrasse 46 where he worked until his death in 1870. 21 That private eye clinic was a model for many eye clinics in Europe in the 19th century ( Figure 5).…”

Section: Working Placesmentioning

confidence: 99%

Places where famous ophthalmologist Albrecht von Graefe lived and worked in Berlin

Ivanišević

2019

AMHA

View full text Add to dashboard Cite

Many things are said and written about famous ophthalmologist Albrecht von Graefe. This work gives detailed description of the places where he lived and practiced ophthalmology in Berlin, because very little was written about it and never in one paper. Von Graefe was born in 1828 in villa Finkenherd in the north-west part of Tiergarten in Berlin. He lived in Behrenstrasse, one of the fashionable streets in Berlin, where he began his ophthalmological practice in 1850. Later, in 1852 he founded a famous private eye clinic in Karlstrasse 46 where he treated numerous eye patients and educated many prominent ophthalmologists and surgeons. Several times he had changed his residence addresses. Among other places, he also stayed in Unter den Linden Avenue and Bellevuestrasse near Potsdamer Platz. In 1868 he became the head of the eye clinic in the Charité Hospital. Since then he lived in a spacious house on Viktoriastrasse until his death in 1870. Although Albrecht von Graefe lived only 42 years, he travelled a lot, but most of his life he spent in the city of Berlin. Graefe made many contributions to ophthalmology being considered the “father of glaucoma” and the nestor of modern ophthalmology.

show abstract

“…! Kaum eine andere medizinische Fachrichtung wurde so durch deutsche Forscher dominiert wie die Augenheilkunde [5]. Früher als andere Disziplinen etablierte Albrecht von Graefe das eigenständige Fach.…”

Section: Augenheilkunde In Deutschlandunclassified

Möglichkeiten der Forschungsförderung - die Ophthalmologie in der DFG

Ziemssen

Meltendorf

2012

Klin Monatsbl Augenheilkd

View full text Add to dashboard Cite

Since 2004 applications for research funding in ophthalmology have been evaluated together with those from neurosurgery, neuropathology, psychiatry, psychotherapy, psychosomatics, otolaryngology and neurology by a joint review board of the German Research Council (DFG). Facing a decreasing number of applications--in contrast to the need and importance of widespread ocular diseases--the working group "young academics" of the Deutsche Ophthalmologische Gesellschaft (DOG) assessed the perception of funding programmes and grants available. Young ophthalmologists think that they have poor prospects to receive funding by a DFG proposal. In comparison, specialist funding quotas show a stable development within the neurosciences over the last years. The sum of requested funding has a strong correlation with the total amount actually paid. By clarifying the number of funded proposals, the better transparency and communication for the existing programmes should improve the cooperativeness, the funding rate and number of applications in future. This inventory explicitly includes a motivational guidance for young researchers to take the initiative to do more proposals.

show abstract

Sesquicentennial of the Ophthalmoscope

Cited by 11 publications

References 18 publications

Funduscopy in Adult Zebrafish and Its Application to Isolate Mutant Strains with Ocular Defects

Funduscopy in Adult Zebrafish and Its Application to Isolate Mutant Strains with Ocular Defects

Places where famous ophthalmologist Albrecht von Graefe lived and worked in Berlin

Möglichkeiten der Forschungsförderung - die Ophthalmologie in der DFG

Contact Info

Product

Resources

About