Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem

Abstract

BackgroundSesquiterpene lactones (STLs) make a diverse and huge group of bio-active constituents that have been isolated from several plant families. However, the greatest numbers are present in Asteraceae family having more than 3000 different reported structures. Recently several researchers have reported that STLs have significant antioxidant and anticancer potentials.MethodsTo investigate the antioxidant, anticancer and antinociceptive potentials of STLs, gravity column chromatography technique was used for isolation from the biologically rich chloroform fraction of Artemisia macrocephala Jacquem. The antioxidant activity of the isolated STLs was determined by DPPH and ABTS free radical scavenging activity, anticancer activity was determined on 3 T3, HeLa and MCF-7 cells by MTT assay while the antinociceptive activity was determined through acetic acid induced writhings, tail immersion method and formalin induced nociception method.ResultsThe results showed that the STLs of Artemisia macrocephala possesses promising antioxidant activity and also it decreased the viability of 3 T3, HeLa and MCF-7 cells and mild to moderate antinociceptive activity.ConclusionSesquiterpenes lactones (STLs) are widely present in numerous genera of the family Asteraceae (compositae). They are described as the active constituents used in traditional medicine for the treatment of various diseases. The present study reveals the significant potentials of STL and may be used as an alternative for the management of cancer. Anyhow, the isolated compound is having no prominent antinociceptive potentials.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1517-y) contains supplementary material, which is available to authorized users.

Vernonia Amygdalina Del. stimulated glucose uptake in brain tissues enhances antioxidative activities; and modulates functional chemistry and dysregulated metabolic pathways

“…The increased GSH and NTP levels, and SOD and catalase activities, with concomitant depletion of MDA level in the treated brain tissues indicate an antioxidative effect. The antioxidative effect of the infusion can be attributed to its identified phytochemical constituents particularly nicotinic acid, salicylic acid and γ-Octalactone, as these compounds have been reported for their antioxidant and neuroprotective activities (De La Cruz et al 2004;Shoaib et al 2017;Tupe et al 2011). This can also be attributed to their predicted permeability across the BBB (Table 5), which corroborates other reports on the ability of polyphenols and alkaloids to cross the BBB (Youdim et al 2003;Zhang et al 2017).…”

Chemical Profile and Antioxidant, Anti-Inflammatory, Antimutagenic and Antimicrobial Activities of Geopropolis from the Stingless Bee Melipona orbignyi

“…In addition, they are capable of modulating the activity of antioxidant enzymes, such as superoxide dismutase, catalase and glutathione peroxidase [33]. Mechanisms similar to the ones described for sesquiterpenes [34], compounds also identified in HEGP.…”

Bioactive Phenolics of the Genus Artemisia (Asteraceae): HPLC-DAD-ESI-TQ-MS/MS Profile of the Siberian Species and Their Inhibitory Potential Against α-Amylase and α-Glucosidase

“…Lastly, with regard to chemical profile of Siberian artemisias, the known data had been very limited. Some terpenoids were detected in A. anethifolia (Evstratova and Sinyukhin, 1971 ; Bakhshyeva et al, 2011 ); essential oil (Zhu et al, 2013 ) and flavonoid aglycones (Wang J.-L. et al, 2016 ) in A. integrifolia ; sesquiterpenes in A. latifolia (Adekenov et al, 1984 ); essential oil (Shoaib et al, 2015 ) and sesquiterpenes (Shoaib et al, 2017 ) in A. macrocephala ; flavonoids in A. palustris (Chemesova et al, 1978 ); coumarins in A. tanacetifolia (Szabó et al, 1985 ); and sesquiterpenes (Tashenov et al, 2013 ) and essential oil (Suleimen et al, 2014 ) in A. umbrosa . There is no chemical information about A. commutata, A. desertorum, A. leucophylla, A. messerschmidtiana , and A. sericea .…”