Sesquiterpene lactone glycosides from Lapsana communis L. subsp. communis.

Fontanel, Didier; Galtier, Christophe; Debouzy, Jean‐Claude; Gueiffier, Alain; Viel, Claude

doi:10.1016/s0031-9422(98)00718-3

Cited by 13 publications

(5 citation statements)

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“…Seco-tanapartholide C is classified in guaiane-type sesquiterpene lactones (SQLs), which are also abundantly present in Compositae (Heinrich et al, 1998). Guaiane-type SQLs have also been found in the glucoside form (Fontanel et al, 1999). Therefore, seco-tanapartholide C may be generated by catalytic activity of β-glucosidase in the fermentation process using the SN13T strain.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-8 Release Inhibitors Generated by Fermentation of Artemisia princeps Pampanini Herb Extract With Lactobacillus plantarum SN13T

et al. 2020

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Some glycosides, which are detected in water extracts from medicinal plants, have been reported to be degraded into their aglycones by incubating with some microorganisms producing β-glucosidase. We have shown that a plant-derived Lactobacillus plantarum SN13T harbors 11 open reading frames (ORFs) encoding the β-glucosidase enzyme and can grow vigorously in several herbal water extracts. In this study, we observed that the water extract from Artemisia princeps Pampanini (AP) fermented with the SN13T strain strongly inhibited the release of interleukin (IL)-8 from the HuH-7 cells, when compared to that without fermentation. Furthermore, we demonstrated that the SN13T strain produced at least two bioactive compounds from some compounds contained in AP extract. In addition, we determined that the two compounds were catechol and seco-tanapartholide C, which dose-dependently inhibited the release of IL-8. Because some sesquiterpene lactones are useful in pharmaceuticals, seco-tanapartholide C may be useful as an anti-inflammatory agent. This study suggests that the fermentation of medicinal herbs with Lb. plantarum SN13T is a significant technique to obtain bioactive compounds having therapeutic potential.

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Section: Discussionmentioning

confidence: 99%

Interleukin-8 Release Inhibitors Generated by Fermentation of Artemisia princeps Pampanini Herb Extract With Lactobacillus plantarum SN13T

et al. 2020

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“…1. The other purified components (4-12) were identified as ixerin N (4) [7], ixerisoside A (5) [8], ixerin M (6) [7], tectroside (7) [8,13], 8-epidesacylcynaropicrin glucoside (8) [7,14], 8-epiisolipidiol (9, 3β,8β-dihydroxy-guaia-10(14)-en-1α,4β,5α,6β,7α,11βH-12,6αolide) [11,12], 11βH-11,13-dihydrointegrifolin (10, 3β,8β-dihydroxy-guaia-4(15),10(14)-dien-1α,5α,6β,7α, 11βH-12,6α-olide) [15,16], 8β-hydroxy-4β,15-dihydrozaluzanin C (11, 3β,8β-dihydroxy-guaia-10(14),11(13)-dien-1α,4β,5α,6β,7αH-12,6α-olide) [11] and integrifolin (12, 3β,8β-dihydroxy-guaia-4(15),10(14),11 (13)-trien-1α,5α,6β,7αH-12,6α-olide) [17] by direct comparison of their spectral data with those in the literature. Details of the workup procedure and copies of the original spectra of 4-12 are obtainable from the author of correspondence.…”

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confidence: 99%

New Guaiane Sesquiterpene Lactones fromIxeris dentata

Cha

Choi

et al. 2010

Planta Med

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Three new guaiane-type sesquiterpene lactones (1-3), together with nine related sesquiterpenes (4-12), were isolated from the whole extract of Ixeris dentata (Asteraceae). The chemical structures of isolates 1-12 were established by spectroscopic analyses as 3 β,8 β-dihydroxy-guaia-10(14)-en-1 α,4 α,5 α,6 β,7 α,11 βH-12,6 α-olide (1), ixerin N 6'- O-acetate (2), ixerisoside A 6'- O-acetate (3), ixerin N ( 4), ixerisoside A (5), ixerin M (6), tectroside (7), 8-epidesacylcynaropicrin glucoside (8), 8-epiisolipidiol (9), 11 βH-11,13-dihydrointegrifolin (10) 8 β-hydroxy-4 β,15-dihydrozaluzanin C (11), and integrifolin (12). Compounds 1-12 were evaluated for their inhibitory effect on the proliferation of the cultured human tumor cell lines MES-SA, MES-SA/DX5, HCT-15, and HCT15/CL02 in vitro.

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“…The cytotoxic effect of crepiside E was also investigated by other authors on SK‐MEL‐2 (human melanoma), SK‐OV‐3 (human ovary adenocarcinoma), HCT15 (human colorectal adenocarcinoma) and A549 cells (concentrations up to 12.7 μg/mL), [47] as well as on L1210 (mouse lymphocytic leukemia) cells (concentrations up to 5.0 μg/mL), [48] but in tested concentrations the compound did not achieve 50 % inhibition of the growth of these cells. On the other hand, desacylcynaropicrin, which is the crepiside E aglycone, was shown to be a potent cytotoxic agent for HeLa ( IC 50 =1.4 μg/mL), [49] SK‐MEL‐2 ( IC 50 =3.6 μg/mL), XF498 (human glioblastoma, IC 50 =3.9 μg/mL), HCT15 ( IC 50 =6.0 μg/mL), SK‐OV‐3 ( IC 50 =11.9 μg/mL) and A549 cells ( IC 50 =13.3 μg/mL) [50] .…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones

Milutinović

Matić

Stanojković

et al. 2022

Chemistry & Biodiversity

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Antimicrobial and cytotoxic activities were tested for dried MeOH extracts of Hieracium calophyllum (CAL), H. coloriscapum (COL), H. pseudoschenkii (PSE), H. valdepilosum (VAL) and H. glabratum (GLA) herbs (flowering aerial parts), their 2 sesquiterpene lactones (SLs) 8‐epiixerisamine A and crepiside E, and dried CH2Cl2 extract of H. scheppigianum (SCH) herb. In microdilution test, extracts showed activity on all tested microorganisms (8 bacteria, 10 fungi). The best effect was exhibited by SCH and CAL on Salmonella Typhimurium (MIC=1.7–2.5 mg/mL MBC=3.4–5.0 mg/mL), and SCH and VAL on Candida albicans (MIC=2.5 mg/mL MFC=5.0 mg/mL). SLs showed notable effect on all tested fungi Aspergillus ochraceus, Penicillium funiculosum, C. albicans and C. krusei (MIC=0.15–0.4 mg/mL MFC=0.3–0.8 mg/mL). In MTT test, extracts inhibited growth of all tested cancer cells (HeLa, LS174 and A549), with the best effect on HeLa (IC50=148.1 μg/mL for SCH, and 152.3–303.2 μg/mL for MeOH extracts); both SLs were active against HeLa cells (IC50=46.2 μg/mL for crepiside E and 103.8 μg/mL for 8‐epiixerisamine A). Extracts and SLs showed good safety profile on normal MRC‐5 cells.

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Sesquiterpene lactone glycosides from Lapsana communis L. subsp. communis.

Cited by 13 publications

References 0 publications

Interleukin-8 Release Inhibitors Generated by Fermentation of Artemisia princeps Pampanini Herb Extract With Lactobacillus plantarum SN13T

Interleukin-8 Release Inhibitors Generated by Fermentation of Artemisia princeps Pampanini Herb Extract With Lactobacillus plantarum SN13T

New Guaiane Sesquiterpene Lactones fromIxeris dentata

Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones

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