Sesquiterpene Lactone–Related Allergic Contact Dermatitis After Exposure to Tulip Poplar Wood and Bark

Wenk, Kurt S.; Tehrani, Mahsa; Ehrlich, Alison

doi:10.1097/der.0b013e31824a644d

Cited by 8 publications

(3 citation statements)

References 2 publications

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“…Bulbous plants (plant/flower growing from a bulb) mostly require manual handling during all stages of growth, and present problems as a result of continuous contact with different parts of the plant containing different profiles of sensitizers. Tulips, because of their long history of cultivation, have proved particularly complex in terms of the development of contact dermatitis .…”

Section: Discussionmentioning

confidence: 99%

“…Owing to manual handling, sensitization can occur at any stage of the growth cycle of the tulip plant in workers who come into contact with this plant. Contact dermatitis caused by tulip plants has already been reported in the literature . Since the description of ‘tulip finger’ by Bertwistle in 1935, several studies have addressed this subject; however, they are mostly case reports and reviews.…”

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confidence: 99%

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Contact dermatitis caused by tulips: identification of contact sensitizers in tulip workers of Kashmir Valley in North India

et al. 2017

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SummaryBackground. Tulip, belonging to the genus Tulipa and family Liliaceae, is a spring-blooming perennial that grows from bulbs. Owing to manual handling, contact dermatitis can occur in professionals at any stage of the growth cycle of the tulip plant. Objectives. To determine the clinical pattern of contact dermatitis resulting from tulip plant cultivation, and to assess contact allergy in workers coming into contact with this plant. Methods. One hundred and sixty-four tulip workers were screened, and 48 patients with suspected contact dermatitis were patch tested with 39 allergens, including haptens from the Indian baseline series, a plant series, and extracts from different parts of the tulip plant. Results. Thirty-nine positive patch test reactions were observed in 21 patients. Seventeen patients showed positive reactions to either -methylene--butyrolactone or to tulip plant extract. Clinical relevance was observed for 13 of 17 positive patch test reactions. Conclusions. Contact dermatitis is an important health hazard in workers dealing with tulip bulbs. Further studies to identify and isolate other possible tulip allergens, and to quantify the amounts of allergens in different parts of the tulip plant, are recommended.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Contact dermatitis caused by tulips: identification of contact sensitizers in tulip workers of Kashmir Valley in North India

et al. 2017

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“…7 However, they can also act as allergens and irritants. 8 Bitter compounds in chicory are of economic importance as well. Since some varieties are used for human consumption, and consumers prefer different bitterness levels depending on the market and traditional uses, 9 having a wider selection of less bitter varieties could push chicory use to new markets.…”

Section: Introductionmentioning

confidence: 99%

Silencing of germacrene A synthase genes reduces guaianolide oxalate content in Cichorium intybus L.

et al. 2019

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Chicory (Cichorium intybus L.) is a medicinal and industrial plant from the Asteraceae family that produces a variety of sesquiterpene lactones (STLs), most importantly bitter guaianolides: lactucin, lactucopicrin and 8-deoxylactucin as well as their modified forms such as oxalates. These compounds have medicinal properties; however, they also hamper the extraction of inulina very important food industry product from chicory roots. The first step in guaianolide biosynthesis is catalyzed by germacrene A synthase (GAS) which in chicory exists in two isoforms-GAS long (encoded by CiGASlo) and GAS short (encoded by CiGASsh). AmiRNA silencing was used to obtain plants with reduced GAS gene expression and level of downstream metabolites, guaianolide-15oxalates, as the major STLs in chicory. This approach could be beneficial for engineering new chicory varieties with varying STL content, and especially varieties with reduced bitter compounds more suitable for inulin production.

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Sesquiterpene Lactone Mix and Compositae Mix

2019

Common Contact Allergens

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Sesquiterpene Lactone–Related Allergic Contact Dermatitis After Exposure to Tulip Poplar Wood and Bark

Cited by 8 publications

References 2 publications

Contact dermatitis caused by tulips: identification of contact sensitizers in tulip workers of Kashmir Valley in North India

Contact dermatitis caused by tulips: identification of contact sensitizers in tulip workers of Kashmir Valley in North India

Silencing of germacrene A synthase genes reduces guaianolide oxalate content in Cichorium intybus L.

Sesquiterpene Lactone Mix and Compositae Mix

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