Sesquiterpene lactones and other constituents from Eremanthus seidelii, E. Goyazensis and Vanillosmopsis erythropappa

Quantitative HPLC analysis of sesquiterpene lactones and determination of chemotypes in Eremanthus seidelii MacLeish & Schumacher (Asteraceae)

“…This phytochemical investigation of E. seidelii leaves revealed the SL 4β,5-dihydro-2',3'-dihydroxy-15-desoxy-goyazensolide (1) and 4β,5-dihydro-1',2'-epoxyeremantholide-C (2) (Figure 1), both already isolated from this species and E. goyazensis, 9 as its major secondary metabolites. Together, these SL can be responsible for up to 7.5% of the weight of the dry leaves (data from plant 6, population A).…”

“…These two SL were identified by comparison of their 1 H and 13 C NMR and ESI-MS data with those previously published. 9,34 Sample preparation for chromatographic analysis Powdered leaves of E. seidelii were weighed (10 mg) in a glass vial and extracted in an ultra-sonic bath for 10 min with 1.5 mL of a solution of MeOH/H 2 O (9:1) J. Braz. Chem.…”

“…1,2 Previous phytochemical investigations with this genus led to the isolation of flavonoids, triterpenes, poliacetylenes and revealed sesquiterpene lactones (SL) as the main secondary metabolites. [3][4][5][6][7][8][9] Some of the SL isolated from the Eremanthus genus posses important biological activities, 3,[6][7][8]10 like the antiproliferative effects on some cancer cell lines 11 and the modulation of the inflammatory process in vitro, by inhibiting the NF-κβ transcriptor factor. 12 Seasonal, [13][14][15][16] circadian [17][18][19] and populational [20][21][22][23][24] variations in the content of almost all classes of secondary metabolites, including SL, [25][26][27][28][29] were reported.…”

“…1,2 Previous phytochemical investigation of this species afforded SL of goyazensolide and eremantholide types. 9 The lack of studies regarding possible temporal or intra-specific variations in E. seidelii secondary metabolism, as well as the lack of studies in this way with plants from the Brazilian "cerrado", led us to develop a method for the quantitative analysis of the major secondary metabolites of this plant.…”

Estudo farmacognóstico de galhos de Vanillosmopsis erythropappa Schult. Bip. - Asteraceae

“…Do óleo da madeira, foram isoladas as lactonas sesquiterpênicas eremantina, goyazensolide, 15-desoxigoyazensolide, lychnofolide, costunolide e bisabolol 2,14 . Além disso, triagem fitoquímica das inflorescências de Vanillomopsis erythropappa demonstrou a presença de flavonóides, taninos, cumarinas, terpenóides, esteróides e saponinas.…”