Sesquiterpene lactones and other secondary metabolites from Crepis commutata (Spreng.) Greuter – Asteraceae

Kotti, Ioanna; Barda, Christina; Karioti, Anastasia; Skaltsa, Helen

doi:10.1016/j.bse.2019.103917

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…The same residues were used for the NMR-metabolomic analysis. C. incana was selected for further analysis andpart of its MeOH: H 2 O (5:1) (9.0 g) extract was fractionated by VLC over silica gel (6.5 cm × 10.0 cm) using mixtures of increasing polarity (cHex: ethyl acetate: MeOH: H 2 O) with gradient elution and afforded ten fractions of 500 mL each (fractions RINA–RINJ) [ 5 , 7 , 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…In detail, sample measurements were carried out by using both nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography coupled with mass spectrometry (LC-MS). Among the under-investigation species, there are no reports in the literature except for C. commutata , C. incana and C. dioscoridis , which have been previously described by our group with emphasis on the non-polar and/or less polar sesquiterpene lactones [ 5 , 7 , 8 ]. In addition, we, herein, examined the polar extracts, which are more likely to contain hydrophilic compounds more relevant to their local use as edible green herbs and potentially potent antioxidant agents.…”

Section: Introductionmentioning

confidence: 99%

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A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.

et al. 2022

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This study was designed to evaluate the chemical fingerprints and the antioxidant, anti-inflammatory and hypolipidemic activity of selected Crepis species collected in Greece, namely, C. commutata, C. dioscoridis, C. foetida, C. heldreichiana, C. incana, C. rubra, and Phitosia crocifolia (formerly known as Crepis crocifolia). For the phytochemical analyses, sample measurements were carried out by using nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography coupled with mass spectrometry (LC-MS). Τhe extracts were evaluated both in vitro (radical scavenging activity: DPPH assay and total phenolic content: Folin–Ciocalteu) and in vivo (paw edema reduction and hypolipidemic activity: experimental mouse protocols). Among the tested extracts, C. incana presented the highest gallic acid equivalents (GAE) (0.0834mg/mL) and the highest antioxidant activity (IC50 = 0.07 mg/mL) in vitro, as well as the highest anti-inflammatory activity with 32% edema reduction in vivo. Moreover, in the hypolipidemic protocol, the same extract increased plasma total antioxidant capacity (TAC) by 48.7%, and decreased cholesterol (41.3%) as well as triglycerides (37.2%). According to fractionation of the extract and the phytochemical results, this biological effect may be associated with the rich phenolic composition; caffeoyl tartaric acid derivatives (cichoric and caftaric acid) are regarded as the most prominent bioactive specialized metabolites. The present study contributes to the knowledge regarding the phytochemical and pharmacological profile of Crepis spp.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.

et al. 2022

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Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis—A Review

Badalamenti

Sottile

Bruno

2022

Plants

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The genus Crepis L., included within the Asteraceae family, has a very wide distribution, expanding throughout the northern hemisphere, including Europe, northern Africa, and temperate Asia. This genus has a fundamental value from biodynamic and ecological perspectives, with the different species often being chosen for soil conservation, for environmental sustainability, and for their attraction towards pollinating species. Furthermore, various species of Crepis have been used in the popular medicine of several countries as medicinal herbs and food since ancient times. In most cases, the species is consumed either in the form of a decoction, or as a salad, and is used for its cardiovascular properties, as a digestive, for problems related to sight, for the treatment of diabetes, and for joint diseases. This literature review, the first one of the Crepis genus, includes publications with the word ‘Crepis’, and considers the single metabolites identified, characterised, and tested to evaluate their biological potential. The various isolated compounds, including in most cases sesquiterpenes and flavonoids, were obtained by extracting the roots and aerial parts of the different species. The secondary metabolites, extracted using traditional (solvent extraction, column chromatography, preparative thin layer chromatography, preparative HPLC, vacuum liquid chromatography), and modern systems such as ultrasounds, microwaves, etc., and characterised by mono- and bi- dimensional NMR experiments and by HPLC-MS, have a varied application spectrum at a biological level, with antimicrobial, antioxidant, antidiabetic, antitumor, antiviral, antiulcer, phytotoxic, and nutritional properties having been reported. Unfortunately, in vitro tests have not always been accompanied by in vivo tests, and this is the major critical aspect that emerges from the study of the scientific aspects related to this genus. Therefore, extensive investigations are necessary to evaluate the real capacity of the different species used in food, and above all to discover what the different plants that have never been analysed could offer at a scientific level.

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Sesquiterpene lactones and other secondary metabolites from Crepis commutata (Spreng.) Greuter – Asteraceae

Cited by 2 publications

References 27 publications

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp.

Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis—A Review

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