Sesquiterpene lactones as chemotaxonomic markers in genus Anthemis

Staneva, Jordanka; Todorova, Milka; Evstatieva, L.

doi:10.1016/j.phytochem.2007.07.021

Cited by 43 publications

(24 citation statements)

References 25 publications

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“…There are more than 5000 SQLs characterized as secondary metabolites in species of the plant kingdom, in particular in the family Asteraceae [1]. This type of NP has received considerable attention because of their diverse structure skeletons and chemotaxonomic significance [2, 3], as well as their potent bioactivities, including antibiotic, antitumor, antiulcer, insect-feeding deterrent, phytotoxic, and schistosomicidal effects [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones

Ren¹,

Yu²,

Kinghorn

2016

CMC

136

121

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Sesquiterpene lactones are of considerable interest due to their potent bioactivities, including cancer cell cytotoxicity and antineoplastic efficacy in in vivo studies. Among these compounds, artesunate, dimethylaminoparthenolide, and L12ADT peptide prodrug, a derivative of thapsigargin, are being evaluated in current cancer clinical or preclinical trials. Based on the structures of several antitumor sesquiterpene lactones, a number of analogues showing greater potency have been either isolated as natural products or partially synthesized, and some potential anticancer agents that have emerged from this group of lead compounds have been investigated extensively. The present review focuses on artemisinin, parthenolide, thapsigargin, and their naturally occurring or synthetic analogues showing potential anticancer activity. This provides an overview of the advances in the development of these types of sesquiterpene lactones as potential anticancer agents, including their structural characterization, synthesis and synthetic modification, and antitumor potential, with the mechanism of action and structure-activity relationships also discussed. It is hoped that this will be helpful in stimulating the further interest in developing sesquiterpene lactones and their derivatives as new anticancer agents.

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Section: Introductionmentioning

confidence: 99%

Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones

Ren¹,

Yu²,

Kinghorn

2016

CMC

136

121

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“…Subgenus Anthemis includes four sections Hiorthia, Anthemis, Maruta and Chia [6]. The genus Anthemis L. is divided into three subgenera (Anthemis, Maruta, and Cota) according to the Flora of Turkey.…”

Section: Introductionmentioning

confidence: 99%

Composition of the Volatile Oils of Anthemis coelopoda var. coelopoda from Turkey

Dogan¹,

Demirpolat²,

Bağcı³

2015

HJBC

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Türkiye'den Anthemis coelopoda var. coelopoda'nın Uçucu Yağ Bileşimi Research Article G. Doğan et al. / Hacettepe J. Biol. & Chem., 2015, 43 (4), 259-265 Gülden Doğan*, Azize Demirpolat and Eyüp Bağcı Firat University, Science Faculty, Biology Department, Elazıg, Turkey.Ö Z E T B u çalışmada Türkiye'de yetişen Anthemis coelopoda var. coelopoda türünün su damıtma yöntemi ile toprak üstü kısımlarından elde edilen uçucu yağları GC ve GC-MS'de analiz edilmiştir. Toplam yağın %90.7'sinde 57 bileşen belirlenmiştir. Anthemis coelopoda var. coelopoda'nın uçucu yağının içerdiği bu bileşenlerden b-karyofillen (%21.8), nerolidol (10.8 %), azulen (%9.5), borneol (%5.5), linalool (%4.3) ve siklopentadekan (%4.2) büyük bileşenlerdir. Uçucu yağ çalışmaları Anthemis coelopoda var. coelopoda için b-karyofillen/ nerolidol ve azulen kemotip olduğunu göstermiştir. Anahtar KelimelerAnthemis, uçucu yağ, b-karyofillen, nerolidol, azulen. A B S T R A C TI n this study, hydro distilled essential oils derived from the aerial parts of Anthemis coelopoda var. coelopoda (Asteraceae) grown in Turkey were analysed by GC and GC-MS system. Fifty seven components were identified representing 90.7% of the oils. It was determined that Anthemis coelopoda var. coelopoda essential oil contained b-caryophyllene (21.8%), nerolidol (10.8%), azulene (9.5%), borneol (5.5%), linalool (4.3%) and cyclopentadecane (4.2%) as major compounds. Essential oil analysis of the Anthemis coelopoda var. coelopoda has shown that it has b-caryophyllene/nerolidol and azulene chemotype.

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“…[7] It is also used for the treatment of cough and cold. [8] The genus Anthemis is characterized mainly by the presence of sesquiterpene lactones, belonging to germacranolides, eudesmanolides, guaianolides[9,10] and flavonoids. [11] The literature survey on A. wiedemanniana revealed the presence of sesquiterpene lactones of germacrane, eudesmane and guaianolide type.…”

Section: Introductionmentioning

confidence: 99%

“…[11] The literature survey on A. wiedemanniana revealed the presence of sesquiterpene lactones of germacrane, eudesmane and guaianolide type. [9,10,11] According to a previous study, linalool, 1,8-cineole, hexadecanoic acid and chrysanthenone were found to be the major compounds characterized in the essential oil of A. wiedemanniana . [6] Fatty acids are known as self defensive agents in organisms and posses various biological activities including anti-inflamation.…”

Section: Introductionmentioning

confidence: 99%

Fatty acid composition and preclinical resarches on Anthemis wiedemanniana Fisch. & Mey.: Discovery of a new anti-inflammatory agent

et al. 2014

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Background:Anthemis species have been used for the treatment of gastrointestinal disorders, hemorrhoid, stomachache and inflammatory diseases in Turkish folk medicine. Anthemis wiedemanniana Fisch. And Mey. is an endemic plant used as painkiller, antispasmodic, sedative and for the treatment of urinary inflammations.Objective:The objective of the present study is to evaluate the anti-inflamatory activity of the extracts of A. wiedemanniana by using in vivo methods.Materials and Methods:Carrageenan-, PGE2- and serotonin-induced hind paw edema, 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema and acetic acid-induced increase in capillary permeability models were used for the anti-inflammatory activity assessment. Moreover, the fatty acid composition of A. wiedemanniana was investigated by gas chromatography (GC).Results:n-Hexane, diethyl ether and total sesquiterpene lactone extracts exhibited significant inhibition in carrageenan-induced hind paw edema and acetic acid-induced increase in capillary permeability model. n-Hexane and total sesquiterperne lactone extracts showed anti-inflammatory activity in PGE2- and serotonin-induced hind paw edema model. However none of the extracts displayed significant activity in TPA-induced ear edema model in mice. C4:0 (Buthyric acid), C20:0 (Arachidic acid) and C16:1 (Palmitoleik acid) were found to be the major fatty acids in these species. Saturated fatty acids (SFA) were found in higher amounts than monounsaturated fatty acids and polyunsaturated fatty acids. SFAs were determined as 63.17%, UFAs as 20.89% and PuFAs as 15.95%.Conclusion:This study confirms the traditional usage of A. wiedemanniana for inflammatory diseases.

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Sesquiterpene lactones as chemotaxonomic markers in genus Anthemis

Cited by 43 publications

References 25 publications

Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones

Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones

Composition of the Volatile Oils of Anthemis coelopoda var. coelopoda from Turkey

Fatty acid composition and preclinical resarches on Anthemis wiedemanniana Fisch. & Mey.: Discovery of a new anti-inflammatory agent

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