Sesquiterpene lactones from Saussurea lappa

Chhabra, B. R.; Gupta, Sanjiv Kumar; Jain, Meenu; Kalsi, P. S.

doi:10.1016/s0031-9422(97)00906-0

Cited by 39 publications

(17 citation statements)

References 8 publications

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“…Root powder ingested with cow's milk and cow's ghee Scalp scabies Essential oil of root is applied al., 1998a), 12-methoxydihydrodehydrocostuslactone (Dhillon et al, 1987), 4␤-methoxydehydrocostus lactone (Singh et al, 1992), saussurealdehyde, isodehydrocostus-lactone-15-aldehyde , sesquiterpene lactones (Kalsi et al, 1995;Ha et al, 1997), 11,13-epoxydehydrocostuslactone, 11,13-epoxy-isozazulanin C, 11,13-epoxydehydroisozaluzamine (Chhabra et al, 1997), 11,13-epoxy-3-keto dehydrocostus-lactone (Chhabra et al, 1998b), cynaropicrin, reynosin, santamarine (Cho et al, 1998), 6,10-dimethyl-9-methyleneunused-S-E-en-2-one (Stepanov and Veselovsky, 1999), (+)-germacrene A, germacra-1(10),4,11(13)-trien-12-al, germacra-1(10), 4,11(13)-trien-12-al, and germacra-1(10), 4,11(13)-trine-12-oic acid (Kraker et al, 2001) were also isolated. 22-Dihydrostigmasterol (Jain and Banks, 1968) and sesquiterpenoides (Maurer and Grieder, 1977) were reported from costus root oil.…”

Section: Conditions Methods Of Applications Referencementioning

confidence: 99%

Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant

Pandey

Rastogi

Rawat

2007

Journal of Ethnopharmacology

197

129

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Section: Conditions Methods Of Applications Referencementioning

confidence: 99%

Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant

Pandey

Rastogi

Rawat

2007

Journal of Ethnopharmacology

197

129

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“…It possesses the function of spasmolysis, antihypertension and antibacteria infection (Jiangsu New Medical College 1977). The chemical constituents of this medicinal herb have been widely studied and many sesquiterpenes, sesquiterpene lactone, triterpenoids, alkaloids, flavonoids, steroids, lignan and tannins have been reported (Dhillon et al 1987;Yang et al 1997a, b;Chhabra et al 1998;Sun et al 2003;Yin et al 2005;Rao et al 2007;Robinson et al 2008;Wang et al 2008;Duan et al 2010). Sesquiterpene lactones including costunolide and dehydrocostus lactone are major components of the root and have been suggested to possess various biological activities, including antitumor, anti-ulcer, anti-inflammatory, neurocytotoxic and cardiotonic activities (Pandey et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Essential oil composition and larvicidal activity of Saussurea lappa roots against the mosquito Aedes albopictus (Diptera: Culicidae)

Liu

Chu

et al. 2011

Parasitol Res

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In recent years, uses of environment friendly and biodegradable natural insecticides of plant origin have received renewed attention as agents for vector control. The aim of this research was to determine larvicidal activity of the essential oil derived from roots of Saussurea lappa (Compositae) and the isolated constituents against the larvae of the Culicidae mosquito Aedes albopictus. Essential oil of S. lappa roots was obtained by hydrodistillation and analyzed by gas chromatography (GC) and GC-mass spectrometry (MS). A total of 39 components of the essential oil of S. lappa roots were identified. The essential oil has higher content of (79.80%) of sesquiterpenoids than monoterpenoids (13.25%). The principal compounds in S. lappa essential oil were dehydrocostus lactone (46.75%), costunolide (9.26%), 8-cedren-13-ol (5.06%), and α-curcumene (4.33%). Based on bioactivity-directed fractionation, dehydrocostus lactone and costunolide were isolated from S. lappa essential oil. Dehydrocostus lactone and costunolide exhibited strong larvicidal activity against A. albopictus with LC(50) values of 2.34 and 3.26 μg/ml, respectively, while the essential oil had an LC(50) value of 12.41 μg/ml. The result indicated that the essential oil of S. lappa and the two isolated constituents have potential for use in control of A. albopictus larvae and could be useful in search of newer, safer and more effective natural compounds as larvicides.

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“…About 40 species have been investigated on their chemical constituents, and sesquiterpenes (Wang et al 2010;Robinson et al 2008;Chhabra et al 1998), triterpenoids (Dai et al 2001), flavonoids (Gao et al 2006), lignans (Duan et al 2002), and phenolic compounds (Li et al 2010) have been reported as the most widespread constituents. Saussurea phyllocephala Coll.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic triterpenoids from Saussurea phyllocephala

Song²,

Yang

et al. 2014

Arch. Pharm. Res.

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Three new triterpenoids, 11α-hydroxy-lup-20(29)-ene-3β-palmitate (1), 28-hydroxy-20-oxo-30-norlupane-3β-palmitate (2), and 1β,11α,28-tyrihydroxy oleana-9(11),12-dien-3β-palmitate (3), together with three known compounds were isolated from the 95 % EtOH extract of Saussurea phyllocephala. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. All the triterpenoids were in vitro evaluated for their cytotoxic activities. Compound 1-3 exhibited the significant cytotoxic activities with low IC50 values (IC50 < 4.0 μM) against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460 and BGC-823).

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Sesquiterpene lactones from Saussurea lappa

Cited by 39 publications

References 8 publications

Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant

Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant

Essential oil composition and larvicidal activity of Saussurea lappa roots against the mosquito Aedes albopictus (Diptera: Culicidae)

Cytotoxic triterpenoids from Saussurea phyllocephala

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