Sesquiterpene Lactones from the Root Tubers of <i>Lindera aggregata</i>

Gan, Li‐She; Zheng, Yang; Mo, Jian‐Xia; Liu, Xin; Li, Xinhua; Zhou, Chang‐Xin

doi:10.1021/np900354q

Cited by 85 publications

(57 citation statements)

References 28 publications

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“…Our findings were in line with previous reports. Gan et al (2009) reported that linderagalactone E (5), linderane, hydroxylindestenolide, and linderalactone showed hepatoprotective activity against H 2 O 2 -induced oxidative damages on HepG2 cells. In addition, huperzine A showed protective activity against H 2 O 2 -induced damage in SHSY5Y cells (Tang et al 2005).…”

Section: Discussionmentioning

confidence: 99%

“…They have long been investigated for biological activities; anticarcinogenic (Afoulous et al 2013), antimicrobial (Wang et al 2013), antifungal (Kundu et al 2013), antiinflammatory (Wang et al 2013), more recently, and antioxidant activities (Abolaji et al 2013). Also it was reported that sesquiterpenes could provide protection against H 2 O 2 damage in many cell lines (Tang et al 2005;Umemura et al 2008;Gan et al 2009;Turkez et al 2013). Cyclosativene (CSV) is a tetracyclic sesquiterpene (Fig.…”

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Protective effects of cyclosativene on H2O2-induced injury in cultured rat primary cerebral cortex cells

et al. 2014

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Sesquiterpenes have attracted much interest with respect to their protective effect against oxidative damage that may be the cause of many diseases including several neurodegenerative disorders and cancer. Our previous unpublished work suggested that cyclosativene (CSV), a tetracyclic sesquiterpene, has antioxidant and anticarcinogenic features. However, little is known about the effects of CSV on oxidative stress induced neurotoxicity. We used hydrogen peroxide (H 2 O 2 ) exposure for 6 h to model oxidative stress. Therefore, this experimental design allowed us to explore the neuroprotective potential of CSV in H 2 O 2 -induced toxicity in newborn rat cerebral cortex cell cultures for the first time. For this aim, MTT and lactate dehydrogenase release assays were carried out to evaluate cytotoxicity. Total antioxidant capacity (TAC) and total oxidative stress (TOS) parameters were used to evaluate oxidative changes. In addition to determining of 8-hydroxy-2-deoxyguanosine (8-OH-dG) levels, the single cell gel electrophoresis (or Comet assay) was also performed for measuring the resistance of neuronal DNA to H 2 O 2 -induced challenge. Our results showed that survival and TAC levels of the cells decreased, while TOS, 8-OH-dG levels and the mean values of the total scores of cells showing DNA damage (Comet assay) increased in the H 2 O 2 alone treated cultures. But pretreatment of CSV suppressed the cytotoxicity, genotoxicity and oxidative stress which were increased by H 2 O 2 . On the basis of these observations, it is suggested that CSV as a natural product with an antioxidant capacity in mitigating oxidative injuries in the field of neurodegenerative disorders.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Protective effects of cyclosativene on H2O2-induced injury in cultured rat primary cerebral cortex cells

et al. 2014

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“…It has been used to treat chest and abdominal pain, indigestion, regurgitation, colds, hernia and frequent urination (22). Studies have demonstrated that L. aggregata extract has antioxidant properties, and can inhibit tumor cell growth and induce apoptosis (23)(24)(25)(26) (27) verified that ILL could induce apoptosis in the human breast cancer MDA-MB-231 cell line, possibly via the inhibition of microRNA hsa-miR-30c expression and increasing the expression of suppressor of cytokine signaling 3 (SOCS3). This in turn inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and regulates the downstream processing of STAT3 pathways, increasing B-cell lymphoma-2 (Bcl-2) and Bcl-extra large protein expression, and inhibiting X-linked inhibitor of apoptosis expression.…”

Section: Introductionmentioning

confidence: 99%

Anti-metastatic effects of isolinderalactone via the inhibition of MMP-2 and up regulation of NM23-H1 expression in human lung cancer A549 cells

et al. 2018

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Abstract. Metastatic lung cancer is a leading cause of mortality and has a mortality rate of ≥90%. Isolinderalactone (ILL) is a sesquiterpene lactone compound that has been used in traditional Chinese medicine. Research has demonstrated that ILL has anti-inflammatory and anti-proliferative properties; however, to the best of our knowledge, studies investigating whether ILL can inhibit lung cancer cell metastasis have not been conducted. In the present study, 1-10 µM ILL was applied in the culturing of the A549 lung cancer cell line to investigate the effects of ILL on the invasion and migration of lung cancer cells, including whether the possible mechanisms of ILL are associated with the expression of matrix metalloproteinase (MMP)-2 and NME/NM23 nucleoside diphosphate kinase 1 (NM23-H1) genes. The results of the present study indicated that ILL inhibited the invasion and migration of the A549 cancer cells and exhibited a dose-response association. ILL also significantly inhibited the protein expression and activity of MMP-2 (P<0.05), exhibiting a trend similar to that of its invasion-and migration-associated properties. Further research revealed that ILL significantly increased the expression of NM23-H1 protein and inhibited the expression of β-catenin protein (P<0.05). The results of the present study is, to the best of our knowledge, the first to confirm that ILL can inhibit the invasion and migration of A549 cancer cells, with the possible mechanisms potentially involving the inhibition of MMP-2 and β-catenin protein expression resulting from the up regulation of NM23-H1 expression. IntroductionCancer is a leading cause of mortality; ~8.2 million people worldwide succumbed to cancer-associated mortality in 2012, with lung cancer accounting for ~1.59 million cases of mortality, or ~20% of the total (1). Lung cancer cell metastasis is a primary cause of mortality and those that experience it have a mortality rate of ≥90% (2). When it metastasizes, lung cancer has a 95% chance of affecting local lymph nodes and an 80% chance of affecting other organs (3,4). Thus, in clinical terms, the overall 5-year survival rate from the time of diagnosis to mortality for patients with lung cancer undergoing treatment is only 10-15% (5). Cancer cell metastasis is a complex multistep process involving invasion and migration (6-8). Matrix metalloproteinases (MMPs) are zinc/calcium-dependent endopeptidases involved in the degradation of the extracellular matrix, two examples of which are MMP-2 and -9 (7,9). MMP-2 is a notable factor in the development of tumor metastasis (7,10). MMP-2 is highly expressed in malignant tumors and serves a key role in cancer invasion and angiogenesis (7,11). The inhibition of MMP-2 is, therefore, an effective strategy for preventing tumor cell metastasis (11,12). The NME/NM23 nucleoside diphosphate kinase 1 (NM23) gene was first identified in the murine melanoma cell line exhibiting high metastatic activity; increasing the expression of this gene may also reduce the metastatic activity of tumor cel...

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“…In China, it is known as Wu Yao and in Japan, Uyaku. Lauraceae is used for treating renal, cystic and rheumatic diseases (9). Lindera aggregata, isolinderalactone, linderalactone and linderane are known sesquiterpenes derived from root tubers.…”

Section: Introductionmentioning

confidence: 99%

Isolinderalactone inhibits proliferation of A549 human non-small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway

Chang¹,

Lin²,

Tsai³

et al. 2014

Molecular Medicine Reports

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Abstract. Lung cancer is currently the leading cause of cancer-related mortality worldwide. In Taiwan, lung cancer is also the type of malignancy that is the major cause of cancer-mortality. Investigating the mechanism of apoptosis of lung cancer cells is important in the treatment of lung cancer. In the present study, isolinderalactone was demonstrated to exhibit anticancer effects in A549 human non-small cell lung cancer cells. The effect of isolinderalactone on apoptosis, cell cycle distribution p21 levels and the Fas receptor and soluble Fas ligand (sFasL) were assayed in order to determine the mechanism underlying the anticancer effect of isolinderalactone. It was demonstrated that isolinderalactone may induce p21 expression and then cause the cell cycle arrest of A549 cells. The data of the present study also revealed that the Fas/sFasL apoptotic system is significant in the mechanism of isolinderalactone-induced apoptosis of A549 cells. These novel findings demonstrated that isolinderalactone may cause the cell cycle arrest of A549 cells by induction of p21, and induce apoptosis of A549 human non-small-cell lung carcinoma cells through the Fas/sFasL apoptotic system.

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Sesquiterpene Lactones from the Root Tubers of Lindera aggregata

Cited by 85 publications

References 28 publications

Protective effects of cyclosativene on H2O2-induced injury in cultured rat primary cerebral cortex cells

Protective effects of cyclosativene on H2O2-induced injury in cultured rat primary cerebral cortex cells

Anti-metastatic effects of isolinderalactone via the inhibition of MMP-2 and up regulation of NM23-H1 expression in human lung cancer A549 cells

Isolinderalactone inhibits proliferation of A549 human non-small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway

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