Sesquiterpene lactones of Moquiniastrum polymorphum subsp. floccosum have antineoplastic effects in Walker-256 tumor-bearing rats

Martins, Gracianny Gomes; Lívero, Francislaine Aparecida dos Reis; Stolf, Aline Maria; Kopruszinski, Caroline Machado; Cardoso, Cibele C.; Beltrame, Olair Carlos; Queiroz-Telles, José Ederaldo; Strapasson, Regiane Lauriano Batista; Stefanello, Maria Élida Alves; Oude-Elferink, Ronald; Acco, Alexandra

doi:10.1016/j.cbi.2015.01.018

Cited by 21 publications

(22 citation statements)

References 38 publications

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“…Martins et al (2015) also demonstrated a reduced growth of the Walker 256 tumor. The present study is the first to describe the chemopreventive effects of this plant and its ability to prevent chemical carcinogenesis in the intestine.…”

Section: Discussionmentioning

confidence: 97%

“…Finally, our research group described the antineoplastic activity of this extract, its fractions, and isolated compounds in both in vitro and in vivo assays (Strapasson et al, 2012;Martins et al, 2015). The in vivo assays revealed that the dichloromethane fraction of this medicinal plant reduces the growth of Walker 256 carcinosarcoma (Martins et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine

Limeiras¹,

Oliveira²,

Pessatto³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment, simultaneous, and post-treatment. Results showed that MPEE has antigenotoxic potential on the tested protocols pre-and silmultaneous treatment, and the percent damage reductions (%DRs) were 81.88 and 93.12%, respectively. The micronucleus test demonstrated that MPEE has great antimutagenic activity, with %DRs higher than 77.09 in the associated groups. The aberrant crypt focus assay demonstrated anticarcinogenic potential of MPEE as the associated groups showed %DRs that ranged from 62.13 to 95.14%. The study shows that MPEE is nontoxic and has chemopreventive and anticarcinogenic activity, thus it may prove to be a promising medicinal plant in view of its demonstrated properties.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine

Limeiras¹,

Oliveira²,

Pessatto³

et al. 2017

Genet. Mol. Res.

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“…Sesquiterpene lactones, such as 11αH-13-dihydrozaluzanin C, 8-hydroxigochnatiolide A, 8-hydroxi-10-desoxigochnatiolide A, gochnatiolide A, gochnatiolide B, and 10-desoxygochnatiolide A, are considered the bioactive components of MPEE (Piornedo et al, 2011;Strapasson et al, 2012;Martins et al, 2015). Sesquiterpene lactones may interfere with some key biological processes, such as cell signaling, proliferation, and death/apoptosis, and mitochondrial respiration, all of which constitute the molecular basis of their diverse pharmacological activities.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Martins et al (2015) reported that Walker-256 tumor growth was inhibited when rats were treated with a dichloromethane fraction of M. polymorpha. In summary, MPEE is not mutagenic, has antimutagenic potential (preferably by bioantimutagenesis), and is able to reduce the mitotic index, resulting in cell cycle arrest.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies have demonstrated that M. polymorphum ethanolic extracts and isolated compounds have anti-inflammatory (Moreira et al, 2000;Piornedo et al, 2011;David et al, 2014), antispasmodic (Schlemper et al, 2011), and cytotoxic effects in several tumor cell lines (Strapasson et al, 2012;Martins et al, 2015). Components of these extracts include sesquiterpene lactones, triterpenes, diterpenes, flavonoids, and coumarins (Farias et al, 1984;Bohlmann et al, 1986;Sacilotto et al, 1997;Moreira et al, 2000;Catalan et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Moquiniastrum polymorphum subsp floccosum extract: screening for mutagenic and antimutagenic activity

Oliveira¹,

David²,

Pesarini³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Moquiniastrum polymorphum subsp floccosum (Cabrera) 2 R.J. Oliveira et al. Genetics and Molecular Research 15 (4): gmr15048976 G. Sancho is used in traditional Brazilian medicine to treat inflammation and infection, which is supported by scientific data. However, only one study has been conducted on the mutagenic activity of the extract, which has important safety implications. This study evaluated the mutagenic/antimutagenic activity of M. polymorphum ethanolic extract (MPEE) in Allium cepa meristematic cells. Commercial A. cepa seeds were cultured for 120 h. Treatments were performed for 48 h with MPEE (10 mg/mL), methyl methanesulfonate (MMS; 0.01 mg/mL), or in combination (MPEE + MMS). All of the experiments were performed in triplicate. A total of 15,000 cells per treatment were analyzed for chromosomal aberrations and the mitotic index. The results showed that MPEE was not mutagenic. In combination with MMS, MPEE decreased the number of damaged cells and the mitotic index. Interestingly, the most pronounced effect was observed post-treatment when the mitotic index also decreased, suggesting that MPEE may affect the cell cycle. MPEE exhibited antimutagenic activity, and may induce cell cycle arrest in A. cepa.

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Caffeoylquinic Acids: Separation Method, Antiradical Properties and Cytotoxicity

Tamayose

Santos

Roque

et al. 2019

Chemistry & Biodiversity

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Twelve chlorogenic acid derivatives and two flavones were isolated from Moquiniastrum floribundum (Asteraceae, other name: Gochnatia floribunda). Compounds were evaluated in relation to their cytotoxicity and antiradical properties. Cytotoxicity was not observed for compounds, however, chlorogenic acid derivatives showed antiradical activity and were more active than the Trolox standard. Quinic acid esterified with caffeoyl group at C‐4 position showed higher antiradical activity compared to acylation at C‐3 or C‐5 positions. Additional caffeoyl groups esterified in quinic acid increase the antiradical activity observed for 4‐caffeoylquinic acid. Excepted to 3,4‐dicaffeoylquinic acid methyl ester, methyl ester derivatives show higher capacity of trapping radicals than their respective acids. Consequently, the presence of caffeoyl group at C‐4 position of quinic acid is suggested as fundamental to obtain the highest antiradical activity.

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Sesquiterpene lactones of Moquiniastrum polymorphum subsp. floccosum have antineoplastic effects in Walker-256 tumor-bearing rats

Abstract: F1B, which is rich in sesquiterpene lactones, showed antitumor activity against Walker-256 carcinosarcoma. This effect may be, at least in part, related to the induction of apoptosis and inhibition of TNF-α signaling.

Cited by 21 publications

References 38 publications

Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine

Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine

Moquiniastrum polymorphum subsp floccosum extract: screening for mutagenic and antimutagenic activity

Caffeoylquinic Acids: Separation Method, Antiradical Properties and Cytotoxicity

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