Sesquiterpene lactones ofFerula olgae

Liquid-Liquid Chromatography Separation of Guaiane-Type Sesquiterpene Lactones from Ferula penninervis Regel & Schmalh. and Evaluation of Their In Vitro Cytotoxic and Melanin Inhibitory Potential

“…To date, numerous sesquiterpene lactones have been isolated from the roots of F. penninervis [12,[15][16][17]. However, all the previous separation studies have been carried out with the use of conventional preparative chromatographic procedures, such as thin layer chromatography, column chromatography or gel permeation chromatography, which are known to be solvent and time consuming.…”

“…In Kazakh traditional folk medicine, the roots are used internally (decocts) or externally (tinctures, compresses) to treat epilepsy, neurosis, rheumatism and various inflammatory diseases, gastroduodenal ulcers, dyspepsia, wounds, abscesses and tumours [14]. To date, numerous sesquiterpene lactones, including olgin, olgoferin, oferin, laferin, talassins A-B, ferolide, penninervin, ferupennins A-O, lasolide, isolasolide, decipienin F, and carmenin have been isolated from the roots of F. penninervis [12,[15][16][17]. However, to the best of our knowledge, the biological potential of this species and its phytochemical constituents has been almost completely neglected.…”

ChemInform Abstract: Sesquiterpene Lactones from Daucus glaber.

“…From these observations, the gross structure of 1 was elucidated as shown in Fig. The NOE correlations HÀC(5)/HÀC(8), HÀC(5)/Me (13), and HÀC(8)/Me (13) indicated that HÀC(5), HÀC (8), and Me(13) were b-oriented, whereas HÀC(6) and HÀC(7) were a-oriented (Fig. Its relative configuration was deduced from the NOESY data.…”

“…Me(15) correlated to C(3) and C (5), and HÀC(3) and HÀC (5) to C(15), suggesting that Me(15) was connected to C (4). The HMBCs from HÀC (6) to C (11) and C (12) and from HÀC (8) to C (11) and the IR absorption band at 1791 cm À1 suggested the presence of a g-lactone moiety involving C(6) of the C 5 -chain fragment and the C(12)¼O group. The HMBCs from HÀC (6) to C (11) and C (12) and from HÀC (8) to C (11) and the IR absorption band at 1791 cm À1 suggested the presence of a g-lactone moiety involving C(6) of the C 5 -chain fragment and the C(12)¼O group.…”

“…The HMBCs from HÀC (6) to C (11) and C (12) and from HÀC (8) to C (11) and the IR absorption band at 1791 cm À1 suggested the presence of a g-lactone moiety involving C(6) of the C 5 -chain fragment and the C(12)¼O group. The HMBCs from HÀC(8) (d(H) 5.56) to C(1') (d(C) 172.0) of the isovaleryloxy group indicated that the isovaleryloxy group was connected to C (8), and accordingly, the angeloyloxy group to C (11). The HMBCs from HÀC(8) (d(H) 5.56) to C(1') (d(C) 172.0) of the isovaleryloxy group indicated that the isovaleryloxy group was connected to C (8), and accordingly, the angeloyloxy group to C (11).…”