Sesquiterpene pyridine alkaloids from Hippocratea excelsa

Furukawa, Masakatsu; Makino, Mitsuko; Uchiyama, Taketo; Ishimi, Katsuhiro; Ichinohe, Yoshiyuki; Fujimoto, Yasuo

doi:10.1016/s0031-9422(02)00020-1

Cited by 26 publications

(22 citation statements)

References 5 publications

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“…obs.). Fridelanes, triterpenoid quinone methides, tingenone, caleastrol, pristimevin, excelsine, friedelin, canophyllol, canoplyllal, canophyllic acid and sesquiterpene alkaloids have all been previously isolated from H. excelsa (Calzada et al, 1991;Calzada and Mata, 1995;Furukawa et al, 2002), a North American species that is known to have anti-inflamatory and antibacterial properties (Perez et al, 1995;Alanis et al, 2005). The present study appears to be the first confirmation that the root of H. africana has significant antimalarial activity in vivo.…”

Section: Hippocratea Africanasupporting

confidence: 70%

The in-vivo antimalarial activities ofUvaria chamaeandHippocratea africana

Okokon

Ita

Udokpoh

2006

Annals of Tropical Medicine & Parasitology

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The antimalarial activities of ethanolic root extracts of two plants used traditionally as malarial remedies in southern Nigeria, Uvaria chamae (Annonaceae) and Hippocratea africana (Hippocrateaceae), were studied in vivo, in mice infected with Plasmodium berghei berghei. The extract of U. chamae, when given orally at 300-900 mg/kg.day, exhibited significant antimalarial activity against both early and established infections. When established infections were treated, the mean survival time of the mice observed with this extract at 900 mg/kg.day was similar to that seen with the positive control: chloroquine at 5 mg/kg.day. The extract of H. africana, tested at oral doses of 200-600 mg/kg.day, also demonstrated promising blood schizontocidal activity, both in early and established infections. Although the question of their toxicities has still to be fully addressed, it is clear that both U. chamae and H. africana possess considerable antimalarial activity and they, or drugs based on their antimalarial constituents, may prove useful in the treatment of human malaria.

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Section: Hippocratea Africanasupporting

confidence: 70%

The in-vivo antimalarial activities ofUvaria chamaeandHippocratea africana

Okokon

Ita

Udokpoh

2006

Annals of Tropical Medicine & Parasitology

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“…Gastroprotective, antibacterial and anti-inflammatory activity Sesquiterpene evoninoate alkaloids, friedelanes and triterpenoid quinone methides and Calzada et al (1991), Pérez et al (1995), Liao et al (2001), Furukawa et al (2002), Navarrete et al (2002), Reyes-Chilpa et al (2003), Alanis et al (2005) and Aguilar-González et al (2005). Iostephane heterophylla (Asteraceae) Antibacterial, vasorelaxation Bisabolene type sesquiterpenoids, diterpenoids and coumarins Aguilar and Delgado (1995), Campos et al (2000), Mata et al (2001) and Aguilar et al (2001) Ligusticum porteri (Apiaceae) Antibacterial Phtalides Delgado et al (1992), Delgado (1996) and Cegiela-Carlioz et al (2005) Piper sanctum (Piperaceae) Antimycobacterial Aporfinic alkaloids, kawapyrones, piperolides, furanes, pyranes, aromatic compounds.…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity and mutagenic activity of Mexican plants used in traditional medicine

Déciga-Campos

Rivero‐Cruz

Arriaga-Alba

et al. 2007

Journal of Ethnopharmacology

182

106

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“…Sesquiterpene pyridine alkaloids are a large group of highly oxygenated sesquiterpenoids, and are predominantly isolated from the plants of the family Celastraceae [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. These alkaloids have significant biological activities, such as their immunosuppressive [5,15], insect antifeedant, insecticidal [9,16], anti-HIV [6,11,12], antitumor [1,2,17] and antiplasmodial activities [13].…”

Section: Introductionmentioning

confidence: 99%