Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity

Wube, Abraham Abebe; Bučar, Franz; Gibbons, Simon; Asres, Kaleab

doi:10.1016/j.phytochem.2005.07.018

Cited by 63 publications

(69 citation statements)

References 16 publications

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“…The variation of drimane sesquiterpene profiles that was hinted in preliminary investigations was confirmed, but no substantial correlations were found with endophyte community composition. This suggests that any potential antimicrobial metabolites—drimane sesquiterpenes reportedly possess this activity (Wube et al, 2005)—do not affect the formation of an endophytic lifestyle in case of the Warburgia colonizers.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial drimane sesquiterpenes and their effect on endophyte communities in the medical tree Warburgia ugandensis

et al. 2014

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Metabolite profiles (GC–−MS), drimane sesquiterpenes, sugars and sugar alcohols, were compared with bacterial and fungal endophyte communities (T-RFLP, DNA clones, qPCR) in leaves and roots of the pepper bark tree, Warburgia ugandensis (Canellaceae). Ten individuals each were assessed from two locations east and west of the Great Rift Valley, Kenya, Africa, which differed in humidity and vegetation, closed forest versus open savannah. Despite organ- and partially site-specific variation of drimane sesquiterpenes, no clear effects on bacterial and fungal endophyte communities could be detected. The former were dominated by gram-negative Gammaproteobacteria, Pseudomonadaceae and Enterobacteriaceae, as well as gram-positive Firmicutes; the fungal endophyte communities were more diverse but no specific groups dominated. Despite initial expectations, the endophyte community of the pepper bark tree did not differ from other trees that much.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial drimane sesquiterpenes and their effect on endophyte communities in the medical tree Warburgia ugandensis

et al. 2014

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“…Warbugia ugandensis (Canellaceae) Has antiviral activity against measles virus (Parker et al, 2007), cytotoxicity (Choi et al, 2015), antibacterial activity against Staphylococcus aureus (Maobe et al, 2013), Merawie et al, 2013), E. coli, P. aeruginosa, S. boydii, and Streptococcus pneumonia, antifungal activity against Candida albicans (Merawie et al, 2013). Contain kaempferol and galangin, naringenin, flavanone and (Yonga, 2011); coloratane sesquiterpenes demonstrates antimicrobial activity (Wube et al, 2005).…”

Section: Rothecamentioning

confidence: 99%

Medicinal plants used in the management of diabetes by traditional healers of Narok County, Kenya

Kamau¹,

Mbaabu²,

Karuri³

et al. 2017

TANG [HUMANITAS MEDICINE]

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The Maasai community from Kenya is highly esteemed for their strong adherence to traditional cultures and ethno medicine. This is attributed to their age-old traditional mechanisms of passing down knowledge to the younger generation. Adoption to new socio-economic lifestyle and urbanization has been associated with development of diabetes, which has been reported among some indigenous pastoral communities in Kenya. Documentation of traditional methods of treatment and management of diabetes by the Maasai has not yet been reported, yet it is noteworthy. Thirty traditional healers from Narok County were purposively selected and interviewed about traditional knowledge of antidiabetic medicinal plants, parts used, preparation dosage and administration. A total of 14 antidiabetic plant species distributed within 13 genera and 12 families were identified and documented as herbal medicine used in the management of diabetes. The most highly cited plant species was Dovyalis abyssinica (20%), the plant family Flacourtiaceae and Rhamnaceae (2 plant species each) recorded the highest number of plant species while the most frequently used plant part was the roots (46%). Literature review revealed that some of the cited plants have known phytochemicals with antidiabetic activity; the study recommends further scientific investigation to validate their efficacy and safety.

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“…Phytochemical investigations of W. ugandensis showed the presence of ugandensolide (29), ugandesidial (cinnamodial) (7), warburgin (30) and warburgiadione (31) from the heartwood (Brooks & Draffan, 1969), cinnamolide (32), cinnamolide-3b-acetate (33), 11a-hydroxymuzigadiolide (34), 7a-hydroxy-8-drimen-11,12-olide (35), deacetylugandensolide (19), linoleic acid (36), mukaadial (9), muzigadiolide (37), ugandensolide (29), ugandensidial (cinnamodial) (7), muzigadial (cannelal) (6), pereniporin B (38), polygodial (4) and waburganal (3) from the stem bark (Kioy et al, 1990;Kubo et al, 1976;Wube et al, 2005); and monoterpenes (Kioy et al, 1990) from the leaves. Wube et al (2005) isolated coloratane sesquiterpenes 6a,9a-dihydroxy-4(13),7-coloratadien-11,12-dial (39), 4(13),7-coloratadien-12,11-olide (40), and 7b-hydroxy-4(13),8-coloratadien-11,12-olide (41) from the stem bark of W. ugandensis.…”

Section: Phytochemistrymentioning

confidence: 99%

“…Warburgia salutaris, W. stuhlmannii and W. ugandensis have yielded a series of drimane sesquiterpenoids such as isopolygodial, muzigadial, polygodial, salutarisolide, ugandensidial and warburganal (Brooks & Draffan, 1969;Jansen & de Groot, 1991;Kioy et al, 1990;Kubo et al, , 1983Manguro et al, 2003;Mashimbye et al, 1999a;Rabe & van Staden, 2000;Wube et al, 2005;Xu et al, 2009). The genus certainly has a high use value.…”

Section: Introductionmentioning

confidence: 99%

The genusWarburgia: A review of its traditional uses and pharmacology

Maroyi

2013

Pharmaceutical Biology

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Context: Warburgia (Canellaceae) species have a long history of ethnomedicinal uses in east, central and southern Africa. Due to the popularity of Warburgia as a source of ethnomedicines; all the species are severely over-harvested throughout their distributional ranges. Objective: This review documents fragmented information on traditional uses and pharmacological evidence of the genus Warburgia. Methods: Information on Warburgia species was collected from scientific journals, books, theses and reports via library and electronic search using Medline, Pubmed, Google Scholar, ScienceDirect and Web of Science. Results: Ethnomedicinal uses of Warburgia species have been recorded from east, central and southern Africa for 30 human and 7 animal ailments. Warburgia species are used to treat gastrointestinal disorders, cold, cough and sore throat; fever or malaria, respiratory and odontological ailments. Warburgia species are rich in drimane and colorotane sesquiterpenoides, and other compounds. The extracts of Warburgia, particularly those from stem bark and leaves, exhibited a wide range of pharmacological effects, including antibacterial, antifungal, antimycobacterial, antioxidant, anti-inflammatory, antifeedant, antiplasmodial, antileishmanial, anthelmintic, cytotoxic and molluscicidal activities. Conclusion: Pharmacological results have validated the use of this genus in traditional medicine. Further investigations are needed to explore the bioactive compounds responsible for the in vitro and in vivo pharmacological effects and their mode of action.

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Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity

Cited by 63 publications

References 16 publications

Antimicrobial drimane sesquiterpenes and their effect on endophyte communities in the medical tree Warburgia ugandensis

Antimicrobial drimane sesquiterpenes and their effect on endophyte communities in the medical tree Warburgia ugandensis

Medicinal plants used in the management of diabetes by traditional healers of Narok County, Kenya

The genusWarburgia: A review of its traditional uses and pharmacology

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