Sesquiterpenoids and diterpenoids from the Chilean liverwort Lepicolea ochroleuca

Liu, Huei-Ju; Wu, Chia‐Li; Becker, Hans; Zapp, Josef

doi:10.1016/s0031-9422(99)00609-3

Cited by 35 publications

(33 citation statements)

References 14 publications

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“…The IR spectrum indicated the presence of a hydroxy group (3435 cm À1 ). The 1 H NMR spectrum showed two methine protons [d 0.46 (1H, dd, J = 11.2, 9.6 Hz, H-6), 0.68 (1H, ddd, J = 11.2, 9.6, 6.8 Hz, H-7)] and two methyl groups [d 1.06 (3H, s, H-12), 1.12 (3H, s, H-13)], characteristic for the presence of a cyclic propane in the aromadendrane skeleton (Liu et al, 2000). The coupling constant (J = 9.6 Hz) between H-6 and H-7 suggested H-6 and H-7 are in cis form (Bohlmann et al, 1983).…”

Section: Resultsmentioning

confidence: 99%

“…In addition to the eight new compounds (1-8) above, the following 22 known compounds were isolated: spathulenol (9) (Ulubelen et al, 1994), (6a,7a)-4b-hydroxy-10a-methoxyaromadendrane (10) (Anjaneyulu et al, 1995), (À)-ent-4b-hydroxy-10a-methoxyaromadendrane (11) (Liu et al, 2000), 4b,10a-dihydroxyaromadendrane (12) (Goldsby and Burke, 1987), pipelol A (13) (Masuoka et al, 2002), de-O-methylsericealactone (14) (Takaoka et al, 1993b), neoliacinolide A (15) (Takaoka et al, 1993a), pseudoneoliacine (16) (Li and Duh, 1993), b-caryophyllene oxide (17) H NMR data (d) were measured in CDCl 3 at 400 MHz for 5 and 7, in acetone-d 6 at 400 MHz for 6. b Exchangeable with D 2 O. Fig.…”

Section: Resultsmentioning

confidence: 99%

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Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them

et al. 2011

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them

et al. 2011

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“…obscura [71] , Ptilidium ciliare [72] , Jubula japonica [73] , Dumortiera hirsuta [74,75] , Lejeunea aquatica, Lejeunea flava and Lejeunea japonica [76] , Plagiomnium acutum [77] , Chiloscyphus polyanthus [78] , Chiloscyphus subporosus [79] , Porella swartziana [80] , Porella recurva [81] , Porella subobtusa [82] , Porella acutifolia subsp tosana [83,84] , Scapania undulata [85] , Lepicolea ochroleuca [86] , Gackstroemia sp., Dendromastigophora sp., [87] Lepidozia fauriana [88] , etc. These liverwort genera possessing sesquiterpenoid compound could be exploited as a natural source of cytotoxic compounds.…”

Section: Sesquiterpenesmentioning

confidence: 99%

Therapeutic potential of bryophytes and derived compounds against cancer

Dey

Mukherjee²

2015

Journal of Acute Disease

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A B S T R A C TObjective: Bryophytes, taxonomically placed between the algae and the pteridophytes, are divided into three classes such as Liverworts, Hornworts and Mosses. Indigenous use involves this small group of plants to treat various diseases. Bryophytes have been investigated pharmacologically for active biomolecules. Several constituents with therapeutic potential have been isolated, characterized and investigated for antibacterial, antifungal, antiviral, antioxidative, antiinflamatory and anticancerous efficacy. Methods: The present review deals with the literature covering the anticancerous potential of bryophytes. Apart from the examples of the compounds and the containing bryophyte genera, the authors have tried to include the examples of cancer cell lines on which the efficacy have been tested and the mode of action of certain cytotoxic agents. Results: Crude extracts and isolated compounds from bryophytes were found to possess potent cytotoxic properties. Different types of terpenoids and bibenzyls have been reported among the most potent cytotoxic compounds. Most of these compounds were found to induce apoptosis by activating a number of genes and enzymes. Biochemical markers such as DNA fragmentation, nuclear condensation, proteolysis of poly (ADPribose) polymerase, activation of caspases, inhibition of antiapoptotic nuclear transcriptional factor-kappaB, activation of p38 mitogen-activated protein kinase etc. have been found to be associated with apoptotic and necrotic response. Conclusions: This review summarizes recent scientific findings and suggests further investigations to evaluate the cytotoxic efficacy of bryophytes.

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“…Stephani collected near Puerto Cisnes (Region XI). (Liu et al 2000, Asakawa 2001, Asakawa et al 2009, Chung-Feng & Hong-Xiang 2009Tori et al 1994, Toyota et al 2004, Ludwiczuk & Asakawa 2008. Sesquiterpenoids, ledol, and fusicoccanoids have been isolated from L. ochroleuca (Liu et al 2000), which grows frequently and abundantly on Pilgerodendron uviferum (D. Don) Florin and Nothofagus spp.…”

Section: Uses Of Bryophytesmentioning

confidence: 99%

Bioprospecting: A Tool to Conserve Chilean Bryophytes

Cuvertino-Santoni

Montenegro

2013

Gayana Bot.

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Here, we present the current state of knowledge on the diversity of Chilean bryophytes (mosses, liverworts, and hornworts), the secondary metabolites present in these plants, and the biological activity of extracts from populations of Chilean species. Our goal is to establish the potential of these plants as a source of useful molecules for pharmaceutical and agricultural industries, thus promoting their conservation. Only 3,7% of Chilean bryophytes (55 spp.) have been analyzed using chemical characterization of their extracts (methanol, ether, ethanol, dichloromethane, acetone and hexane). Only four species from Chilean and Argentinian populations (Porella chilensis (Lehm. & Lindenb.) Trevi., Riccardia polyclada (Mitt. ex Thurn) Hässel, Balantiopsis cancellata (Nees) Stephani, and Sphagnum magellanicum Brid.) have been evaluated for biological activity. The majority of these studies have concentrated on liverworts widely distributed in the Southern Hemisphere and in the temperate forests of the southern half of Chile and adjacent Argentina. We briefly discuss aspects related to the use of bioprospecting as a conservation tool as well as the maintenance of in vitro bryophyte cultures with the goal of conservation and production. KEYWORDS:Mosses, liverworts, hornworts, uses, secondary metabolites, biological activity, in vitro cultivation. RESUMENEsta revisión presenta el estado actual del conocimiento de la diversidad de las briófitas chilenas (musgos, hepáticas y antocerotas), de los metabolitos secundarios de estas plantas y de la actividad biológica de extractos obtenidos a partir de especies de poblaciones chilenas. Nuestro objetivo es determinar el potencial de estas plantas como fuente de moléculas útiles para las industrias farmacéutica y agroalimentaria, y promover su conservación. Sólo de un 3,7% de las briófitas chilenas (55 spp.) han sido analizados químicamente sus extractos (metanol, éter, etanol, diclorometano, acetona y hexano). Se ha evaluado la actividad biológica sólo de cuatro especies de poblaciones chileno-argentinas (Porella chilensis (Lehm. & Lindenb.) Trevi., Riccardia polyclada (Mitt. ex Thurn) Hässel, Balantiopsis cancellata (Nees) Stephani, y Sphagnum magellanicum Brid.). La mayor parte de los estudios se ha concentrado en hepáticas de amplia distribución en el Hemisferio Austral y en los bosques templados de Chile y Argentina. Se discuten brevemente aspectos relacionados a la bioprospección como herramienta para la conservación, y al cultivo in vitro de briófitas con fines productivos y de conservación. PALABRAS CLAVE:Musgos, hepáticas, antocerotas, usos, metabolitos secundarios, actividad biológica, cultivo in vitro.

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Sesquiterpenoids and diterpenoids from the Chilean liverwort Lepicolea ochroleuca

Cited by 35 publications

References 14 publications

Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them

Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them

Therapeutic potential of bryophytes and derived compounds against cancer

Bioprospecting: A Tool to Conserve Chilean Bryophytes

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