Sesquiterpenoids and flavonoids from Pteris multifida Poir.

Hou, Mengyang; Chen, Yan; Wang, Youzhong; Hao, Kexin

doi:10.1016/j.bse.2021.104320

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…For example, species of the genus Pteris are rich in flavonoids with mainly α-and β-glucosides, galactosides, rhamnosides or arabinosides present. [13,14] Distinctive flavonoids that have been isolated include neoflavonoids, calomelanols A-J (5-14) from farinose of Pityrogramma calomelanos (L.) Link, [15,16] bioflavonoids such as hinokiflavone (15), 7″-O-methylhinokiflavone (16) amentoflavone (17) and 7,7″-di-Omethylamentoflavone (18) from Selaginella tamariscina Examples of secondary metabolites isolated from ferns and lycophytes: alkaloids (1-4), complex flavonoids , sesquiterpenoids (29)(30)(31)(32) and miscellaneous natural products (33)(34)(35)(36)(37); *stereogenic centres were not assigned in these molecules www.publish.csiro.au/ch Australian Journal of Chemistry (P.Beauv.) Spring, [17] involvenflavones A-F (19)(20)(21)(22)(23)(24) from S. involven (Sw.) Spring [18] and prenylated flavonoids (25)(26)(27)(28) from Helminthostachys zeylanica (L.) Hook.…”

Section: Introductionmentioning

confidence: 99%

“…[20] For example, multifidosides A-C (29-31) have been isolated from Pteris multifida Poir. [14] and the carcinogenic pteroside, ptaquiloside (32) has been isolated from Pteridium aquilinium (L.) Kuhn. [21] The terpenoids obtained from ferns are typically ent-kaurane-, ent-atisane-and ent-primarane-type diterpenoids, which are present in Pteris species.…”

Section: Introductionmentioning

confidence: 99%

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Natural products isolation studies of native Australian fern species

2022

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Natural products isolation studies of 16 native Australian fern species have been undertaken, facilitated by pressurised hot water extraction (PHWE). Fourteen of these fern species have not been the subject of natural products isolation research previously. In total, 14 different compounds were isolated from 12 of these 16 different fern species. This included γ-and δ-lactones; flavonoid glycosides, a dihydrobenzofuran neolignan, in addition to hydroxycinnamate/caffeic acid esters. More specifically, the lactones 5,6-dihydro-5-hydroxy-6-methyl-2H-pyran-2-one, 5-(1hydroxyethyl)-2(5H)-furanone and osmundalin were obtained from Todea barbara, while a dihydrobenzofuran neolignan, (−)-trans-blechnic acid were found in Austroblechnum pennamarina subsp. alpina, and the shikimate ester 5-O-caffeoylshikimic acid was isolated from Parablechnum wattsii. In addition, flavonoids and their glycoside derivatives, kaempferol 3-Oglucopyranoside, 4β-carboxymethyl-(−)-epicatechin, (2R)-eriodictyol-7-O-β-D-glucopyranoside, naringin, quercitrin, quercetin 3-O-(6″-acetyl)-β-D-glucopyranoside, rutin, and tiliroside were isolated from seven other fern species.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Natural products isolation studies of native Australian fern species

2022

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Cytotoxic n-Hexane Fraction of the Egyptian Pteris vittata Functions as Anti-breast Cancer Through Coordinated Actions on Apoptotic and Autophagic Pathways

Mohany

Shakour

Mohamed

et al. 2023

Appl Biochem Biotechnol

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We investigated the possible anticancer mechanisms of Pteris vittata [PV] n-hexane extract on MCF-7 [breast cancer cell line]. Cultured cell lines were treated with various concentrations of this extract ± Baf-A1 [autophagic inhibitor]. Cells’ viability, apoptotic markers [caspase-7, Bax, and Bcl-2], autophagic markers [light chain 3 [LC-3] and P62/SQSTM1]], and the tumor suppressor P53 and its mRNA were checked by their corresponding methods. Treated cell lines showed significant concentration and time-dependent reductions in cell viability in response to PV-n-hexane extract and also exhibited a concomitant induction of apoptosis [increased chromatin condensation, nuclear fragmentation, and pro-apoptotic Bax, and cleaved caspase-7 levels while decreased Bcl-2 levels] and autophagy [increased autophagosomes vacuoles, and LC3B II levels while decreased P62/SQSTM1 levels]. Moreover, PV-n-hexane extract-treated cells showed significant increases in the P53 and its mRNA levels. The addition of Baf-A1 reversed the PV-n-hexane extract autophagic effects and increased apoptotic cell percentage with a much increase in the cleaved caspase-7 and P53 protein and its mRNA levels. We concluded that the PV-n-hexane extract exhibits cytotoxic effects on the MCF-7 cell line with significant reductions in cell viability and concomitant autophagy and apoptosis induction. Inhibition of autophagy in the PV-treated MCF-7 cells enhances apoptosis via a p35-dependent pathway.

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