Sesquiterpenoids and monoterpenoids from the water decoction of Valeriana officinalis L

Li, Shiwei; Xue, Bian-Xia; Yang, Tian-Tian; Li, Ran; Zhang, Mingjie; Wang, Miao; Zhang, Lihua; Zhang, Peng; Zhang, Yi; Wang, Tao; Wang, Shaoxia; Wu, Hong‐Hua

doi:10.1016/j.phytochem.2022.113474

Cited by 11 publications

(13 citation statements)

References 37 publications

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“…[ 25,37 ] Akt (protein kinase B), a serine/threonine‐specific protein kinase that mostly requires phosphorylation for activation, was reported to negatively regulate the pro‐apoptotic components of the Bcl‐2 family, such as Bad, to inhibit cell apoptosis. [ 38 ] To verify the role and potential mechanism of TPC in the apoptosis of BMSCs induced by DEX, the following experiments were conducted:…”

Section: Resultsmentioning

confidence: 99%

Effects of Puerarin‐Loaded Tetrahedral Framework Nucleic Acids on Osteonecrosis of the Femoral Head

Zhao

Feng

et al. 2023

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Osteonecrosis of the femoral head (ONFH) is recognized as a common refractory orthopedic disease that causes severe pain and poor quality of life in patients. Puerarin (Pue), a natural isoflavone glycoside, can promote osteogenesis and inhibit apoptosis of bone mesenchymal stem cells (BMSCs), demonstrating its great potential in the treatment of osteonecrosis. However, its low aqueous solubility, fast degradation in vivo, and inadequate bioavailability, limit its clinical application and therapeutic efficacy. Tetrahedral framework nucleic acids (tFNAs) are promising novel DNA nanomaterials in drug delivery. In this study, tFNAs as Pue carriers is used and synthesized a tFNA/Pue complex (TPC) that exhibited better stability, biocompatibility, and tissue utilization than free Pue. A dexamethasone (DEX)‐treated BMSC model in vitro and a methylprednisolone (MPS)‐induced ONFH model in vivo is also established, to explore the regulatory effects of TPC on osteogenesis and apoptosis of BMSCs. This findings showed that TPC can restore osteogenesis dysfunction and attenuated BMSC apoptosis induced by high‐dose glucocorticoids (GCs) through the hedgehog and Akt/Bcl‐2 pathways, contributing to the prevention of GC‐induced ONFH in rats. Thus, TPC is a promising drug for the treatment of ONFH and other osteogenesis‐related diseases.

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Section: Resultsmentioning

confidence: 99%

Effects of Puerarin‐Loaded Tetrahedral Framework Nucleic Acids on Osteonecrosis of the Femoral Head

Zhao

Feng

et al. 2023

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“…Four previously undescribed compounds (1-4) along with twenty known ones (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) were isolated from a cytotoxic nbutanol fraction of the 80 % aqueous ethanol extract of S. lyratum (SLNF). Their structures were determined by analysis of the MS and NMR data, and ECD calculation and comparison.…”

Section: Resultsmentioning

confidence: 99%

“…[8] In the HMBC spectra of 1-4, the correlations from δ 2). Herein, the β-configurations of glucopranosyl and galactopyranosyl moieties were deduced by the fact that the coupling constants ( 3 J 1,2 ) of their anomeric protons were all above 7.0 Hz, [8] and the monosaccharide composition and the D-configurations of glucopranosyl and galactopyranosyl moieties were established based on the comparative PMP (1- phenyl-3-methyl-5-pyrazolone)-HPLC analysis [9] on the acid hydrolysate of compound 1 with those PMP derivatives of standard sugars. J-values are in parentheses and reported in Hz; chemical shifts are given in ppm; assignments were confirmed by HSQC, HMBC, and 1 H-1 H COSY experiments.…”

Section: Resultsmentioning

confidence: 99%

Steroidal Saponins from Solanum lyratum Thunb.

Lai,

Zhao,

Gao

et al. 2023

Chemistry & Biodiversity

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Four undescribed steroidal compounds along with twenty known compounds were isolated from n‐butanol extracted fraction of the whole plants of Solanum lyratum Thunb (SLNF). Their structures were assigned based on analyses of the extensive spectroscopic data (including MS, 1D/2D NMR, and ECD) or comparisons of the NMR data with those reported. Among the knowns, three compounds were isolated from Solanum plants for the first time, while one compound was isolated from S. lyratum for the first time. In addition, the cytotoxicities of these isolates against human colon SW480 and hepatoma Hep3B cells were evaluated by a MTT assay. And, nine of them and SLNF exhibited significant activities against both SW480 and Hep3B cells, while twelve of them significantly inhibited the activities of SW480 cells. This study allows for the exploitation of chemical markers with potential significance in discrimination of Solanum plants, and uncovers the diverse steroidal constituents from S. lyratum dedicated for its future application in cancer treatment.

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“…A similar process as reported in our previous study, relative configuration of 1 was deduced by analysis of the NMR data and Chem3D modeling. [32,43] Detailed instructions are available in the Supplementary Information.…”

Section: Ecd Calculationmentioning

confidence: 99%

Furfural Derivatives and Phenolic Constituents in Stemona tuberosa Lour

He,

Li,

Yang

et al. 2023

Chemistry & Biodiversity

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Chemical investigation on the water‐soluble constituents of Stemona tuberosa Lour. resulted in the isolation of a previously undescribed furfural derivative namely (S)‐5‐((R)‐Hydroxy(5‐(hydroxymethyl)furan‐2‐yl)methyl)‐5‐methylfuran‐2(5H)‐one and twenty‐five known compounds from the water decoction of the dried root tubers. Their structures were determined by analysis of the extensive spectroscopic data, including 1D/2D NMR, HRESIMS, and ORD, as well as the ECD simulation and comparison. Most of them were phenolic and among them, four compounds were isolated from Stemona plants for the first time. This study uncovers diverse constituents from water decoction of S. tuberosa dedicated for its quality control and allows for the exploitation of chemical markers with potential significance for discrimination of Stemona plants.

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Sesquiterpenoids and monoterpenoids from the water decoction of Valeriana officinalis L

Cited by 11 publications

References 37 publications

Effects of Puerarin‐Loaded Tetrahedral Framework Nucleic Acids on Osteonecrosis of the Femoral Head

Effects of Puerarin‐Loaded Tetrahedral Framework Nucleic Acids on Osteonecrosis of the Femoral Head

Steroidal Saponins from Solanum lyratum Thunb.

Furfural Derivatives and Phenolic Constituents in Stemona tuberosa Lour

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