Sesquiterpenoids from Atractylodes macrocephala act as farnesoid X receptor and progesterone receptor modulators

Tsai, Chuen-Tinn; Liang, Jui-Wei; Lin, Hsiang‐Ru

doi:10.1016/j.bmcl.2012.01.048

Cited by 30 publications

(16 citation statements)

References 22 publications

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“…magnolol) from M. officinalis (23), sesquiterpenoids (e.g. atractylenolide I) from A. macrocephala (24), flavonoids (e.g. hesperidin) from C. reticulate (25), phenolic acid (e.g.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi-san via enhancement of heme oxygenase-1 expression in RAW264.7 macrophages

Jeong

Kim

Yoo

et al. 2016

Molecular Medicine Reports

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Gwakhyangjeonggi‑san (GHJGS) is a mixture of herbal plants, including Agastache rugosa, Perilla frutescens, Angelica dahurica, Areca catechu, Poria cocos, Magnolia officinalis, Atractylodes macrocephala, Citrus reticulata, Pinellia ternata, Platycodon grandiflorum, Glycyrrhiza uralensis, Ziziphus jujuba and Zingiber officinale. GHJGS has been used for treating diarrhea‑predominant irritable bowel syndrome in traditional Korean medicine. In the present study, the anti‑inflammatory and antioxidant effects of GHJGS were investigated using the RAW 264.7 murine macrophage cell line. GHJGS significantly reduced production of the proinflammatory cytokines, tumor necrosis factor‑α, interleukin‑6 and prostaglandin E2 in lipopolysaccharide (LPS)‑stimulated macrophages. GHJGS markedly suppressed LPS‑induced phosphorylation of mitogen‑activated protein kinases, whereas it had no effect on nuclear factor‑κB activation. Furthermore, GHJGS enhanced expression of heme oxygenase‑1 and prevented the generation of reactive oxygen species in RAW 264.7 cells. These results indicate that GHJGS is a viable therapeutic agent against inflammation and oxidative stress‑associated disorders.

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“…magnolol) from M. officinalis (23), sesquiterpenoids (e.g. atractylenolide I) from A. macrocephala (24), flavonoids (e.g. hesperidin) from C. reticulate (25), phenolic acid (e.g.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi-san via enhancement of heme oxygenase-1 expression in RAW264.7 macrophages

Jeong

Kim

Yoo

et al. 2016

Molecular Medicine Reports

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“…The extraction of the soluble fraction of the A. macrocephala with ethyl acetate allowed the isolation of atractylenolide II (9) andatractylenolide III (10) (Fig. 4), which are sesquiterpenoids able to inhibit the CDCA-induced FXR activation in dose dependent-manner (IC 50 = 50 μM) [45].…”

Section: Triterpenes Sterols and Derivativesmentioning

confidence: 99%

Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands

Carotti¹,

Marinozzi²,

Custodi³

et al. 2014

CTMC

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The modulation of FXR receptor remains an attractive area in drug discovery to develop novel therapeutic opportunities for liver and metabolic disorders. Despite the large variety of FXR ligands reported so far, only a very restricted number of agonists have entered in clinical settings. In this review article we provide the reader with an overview on the different classes of natural and synthetic ligands that have been developed by academic groups and pharmaceutical companies to target FXR. We discuss their structure-activity relationships, analyzing the binding modes that some of these compounds adopt to interact with the receptor.

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“…ginsenoside Rb1 and ginsenoside Rg1) from P. ginseng (Shan et al, 2014), sesquiterpenoids (e.g. atractylenolide I, II, and III) from A. japonica (Tsai et al, 2012), triterpenoids (e.g. pachymic acid and dehydropachymic acid) from P. cocos (Li et al, 2004, Hoang et al, 2005), alkaloid (e.g.…”

Section: Introductionmentioning

confidence: 99%

Quantification of the constituents of the traditional Korea medicine, Samryeongbaekchul-san, and assessment of its antiadipogenic effect

Seo

Yoo

Jeong

et al. 2019

Saudi Pharmaceutical Journal

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Samryeongbaekchul-san (SBS) is a traditional herbal formula, which is used for the treatment of dyspepsia, chronic gastritis, and anorexia in Korea. To evaluate the quality of SBS decoction by quantifying its main constituents simultaneously using high-performance liquid chromatography coupled with photodiode array (HPLC–PDA) detection, and secondly to determine the antiadipogenic effect of SBS decoction. The main constituents in a 10-μL injection volume of the decoction were separated on Gemini C18 and Luna NH2 columns (both 250 mm × 4.6 mm, 5 μm) at 40 °C using a gradient of two mobile phases eluting at 1.0 mL/min. 3T3-L1 preadipocytes were differentiated into adipocytes for 8 days with or without SBS. After differentiation, accumulated triglyceride contents and leptin production were measured. The correlation coefficients of all constituents in a calibration curve were ≥0.9998 and showed good linearity in the tested concentration range after validation of the method established. The recovery of the four major compounds were 99.46–102.61% with intra- and interday precisions of 0.08–1.01% and 0.15–0.99%, respectively. The four compounds in the lyophilized SBS sample were detected up to 6.46 mg/g. SBS treatment of the differentiated adipocytes significantly inhibited lipid accumulation and leptin production without cytotoxicity. Optimized simultaneous determination of constituents by HPLC–PDA detection will help to improve quality assessment of SBS or related formulas. SBS has an antiadipogenic effect and further investigation to establish the mechanisms of action of its antiadipogenic effect is warranted.

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Sesquiterpenoids from Atractylodes macrocephala act as farnesoid X receptor and progesterone receptor modulators

Cited by 30 publications

References 22 publications

Anti-inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi-san via enhancement of heme oxygenase-1 expression in RAW264.7 macrophages

Anti-inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi-san via enhancement of heme oxygenase-1 expression in RAW264.7 macrophages

Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands

Quantification of the constituents of the traditional Korea medicine, Samryeongbaekchul-san, and assessment of its antiadipogenic effect

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