Sesquiterpenoids from the Herb of Leonurus japonicus

Xiong, Liang; Zhou, Qin‐Mei; Peng, Cheng; Xie, Xing; Guo, Li; Li, Xiaohong; Liu, Juan; Liu, Zhaohua; Dai, Ou

doi:10.3390/molecules18055051

Cited by 41 publications

(14 citation statements)

References 19 publications

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“…This compound has demonstrated a large spectrum antibacterial and antifungal effect, as well as antioxidant and anti-inflammatory activity. Beta-caryophyllene also contributes to the antimicrobial properties of S. aromaticum with a broad effect on Gram positive bacteria, as reported by Xiong et al (2013). Regarding the main components of P. nigrum, most terpenes do not possess high inherent antimicrobial activity against many Gram-negative pathogens (Bagamboula et al, 2004;Nazzaro et al, 2013).…”

Section: Antibacterial Activity Of the Essential Oil Testedmentioning

confidence: 81%

Chemical composition, antibiotic promotion and in vivo toxicity of Piper nigrum and Syzygium aromaticum essential oil

Ismail¹,

Kemegne²,

Njayou³

et al. 2017

Afr. J. Biochem. Res.

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The antimicrobial activity of spices of human daily diet has been widely demonstrated. Yet, their capacity of promoting antibiotic activity has not been explored adequately. In this work, the chemical composition of essential oils of Piper nigrum and Syzygium aromaticum from Chad were determined and their antimicrobial effect in combination with different antibiotics towards Staphylococcus aureus, Salmonella enteritidis and Salmonella typhi were assessed. Moreover, the in vivo toxicity of the essential oils alone and in combination with antibiotics was performed. Results indicate that the essential oil of P. nigrum was mostly composed of limonene (18.59%), beta-pinene (11.51%), linalool (10.17%), alpha-pinene (9.96%), while for S. aromaticum essential oil, only three compounds represented about 89% of the identified compounds. They were respectively beta caryophyllene (43.63%), eugenol (42.67%) and alpha-humulene (3.73%). Regarding the antimicrobial properties, Syzygium aromaticum essential oil (EO) used alone was more active than P. nigrum EO with a minimum inhibitory concentration (MIC) of 625 ppm towards all the strains. In combination with selected antibiotics, S. aromaticum gave better results with less indifference association, the best being with gentamicin. This association of the different EOs with gentamicin proved not to be acutely toxic to rats after 14 days of observation at doses ten times the MIC. These results indicated that spices used in human diets can be used for the production of hybrid drugs containing antibiotic and natural substances.Key words: Piper nigrum, Syzygium aromaticum, antibiotic promotion, Staphylococcus aureus, Salmonella, toxicity. INTRODUCTIONSpices are highly used in Chadian diet and many research works indicate that some of them have biological activities (Beuchat, 1994;Shan et al., 2007). In the continuous search for natural compounds with antimicrobial properties, a more safety approach is to use substances already belonging to human diet. Bacterial infection is one of the most current causes of illness worldwide (Kuete, 2013) and especially in developing countries (Adwan et al., 2008). According to Havelaar et al. (2015), food borne diarrheal disease agents, particularly non-typhoidal Salmonella enterica, cause about 23000 death worldwide, with a high percentage in Africa. In the same report, Salmonella Typhi was recognized as one of the major cause of food borne diseases. Regarding Staphylococcus aureus, Tong et al. (2015) stated that in the industrialized world, the population incidence of S. aureus bacteremia ranges from 10 to 30 per 100,000 person/year.Black pepper (Piper nigrum) has many medicinal properties among which, antibacterial, antifungal, antiinflamatory and antidiarrhoeal are mostly reported (Noumedem et al., 2013). Clove (Syzygium aromaticum) is an aromatic herb that has many useful purposes. Its essential oil has demonstrated several properties as reported by Noumedem et al. (2013). S. aromaticum is widely cultivated in Indonesia, Sri Lanka, Madagascar,...

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Section: Antibacterial Activity Of the Essential Oil Testedmentioning

confidence: 81%

Chemical composition, antibiotic promotion and in vivo toxicity of Piper nigrum and Syzygium aromaticum essential oil

Ismail¹,

Kemegne²,

Njayou³

et al. 2017

Afr. J. Biochem. Res.

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“…60 Compound 3 ((2S,5S)-2-hydroxy-2,6,10,10-tetramethyl-1oxaspiro[4.5]dec-6-en-8-one), at a concentration of 10 μM, inhibited platelet aggregation induced by ADP. 61 As such, motherwort shows potential as an antiplatelet herbal medicine and clinical trials are suggested to test this potential action.…”

Section: Motherwort (Leonurus Japonicus)mentioning

confidence: 99%

The Influence of Herbal Medicine on Platelet Function and Coagulation: A Narrative Review

McEwen

2015

Semin Thromb Hemost

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Cardiovascular disease (CVD) is the leading cause of death worldwide. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of CVD and can play a role in modifying CVD progression, particularly in platelet function, and have the potential of altering platelet function tests, as well as some coagulation parameters. Herbal medicines, such as feverfew, garlic, ginger, ginseng, motherwort, St John's wort, and willow bark, were found to reduce platelet aggregation. In vitro studies show promise in the reduction of platelet aggregation for Andrographis, feverfew, garlic, ginger, Ginkgo, ginseng, hawthorn, horse chestnut, and turmeric. In addition, cranberry, danshen, dong quai, Ginkgo, ginseng, green tea, and St John's wort were found to have potential interactions with warfarin. Furthermore, St John's wort interacted with clopidogrel and danshen with aspirin. Therefore, repeat testing of platelet function and coagulation studies, particularly for patients on warfarin therapy, may be required after exclusion of herbal medicines that could have possibly affected initial test results.

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“…has been used as traditional Chinese herbal medicine for thousands of years. The diverse therapeutic applications of L. japonicus may be attributed to its bioactive constituents, which include terpenoid, [ 1–3 ] alkaloids, [ 4 ] flavonoids, [ 4,5 ] glycosides, [ 6 ] peptides [ 7 ] and volatile oils. [ 8 ] Diterpenoids have become widely studied in recent years.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus

Yue

Liang

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Two labdane diterpenoids, leojapone B and heteronone B, were isolated from Leonurus japonicus Houtt., and their biological activity were evaluated in this study. Methods Human and mouse cancer cells, human peripheral blood mononuclear cells (PBMCs) and mouse macrophages (RAW264.7 cells) were used to evaluate the activity of leojapone B and heteronone B, while the in vivo effects of leojapone B were further examined in Lewis Lung Cancer tumour-bearing mice. Key findings In vitro studies showed that leojapone B selectively inhibited the proliferation of lung cancer cells, and both leojapone B and heteronone B inhibited the production of pro-inflammatory cytokines in activated PBMCs. In tumour-bearing mice model, lung tumours were reduced in size in mice treated with intraperitoneal injections of leojapone B at 20 and 30 mg/kg for 14 days. The population ratio of CD4 + /CD8 + T cells in mouse spleens was found to be increased, while regulatory T cells were decreased after leojapone B treatment. Conclusions The inhibitory effects of leojapone B in mouse lung tumours were demonstrated for the first time in this study. The immunomodulatory activity of heteronone B were also demonstrated. Our findings indicated that both leojapone B and heteronone B may act as active components in L. japonicus.

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Sesquiterpenoids from the Herb of Leonurus japonicus

Cited by 41 publications

References 19 publications

Chemical composition, antibiotic promotion and in vivo toxicity of Piper nigrum and Syzygium aromaticum essential oil

Chemical composition, antibiotic promotion and in vivo toxicity of Piper nigrum and Syzygium aromaticum essential oil

The Influence of Herbal Medicine on Platelet Function and Coagulation: A Narrative Review

Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus

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