Sesquiterpenoids of Dendrobium nobileLindl. aqueous extract for inhibition alcoholic liver injury through RTK/ELF4regulated inflammation in mouse hepatic macrophages

Wu, Di; Qin, Lin; Feng, Chengcheng; Cao, Ligang; Ye, Ju; Wu, Xingdong; Tan, Daopeng; He, Yuqi

doi:10.1016/j.arabjc.2023.105501

Arabian Journal of Chemistry

2024

DOI: 10.1016/j.arabjc.2023.105501

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Sesquiterpenoids of Dendrobium nobileLindl. aqueous extract for inhibition alcoholic liver injury through RTK/ELF4regulated inflammation in mouse hepatic macrophages

Di Wu,

Lin Qin,

Chengcheng Feng

et al.

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Cited by 3 publications

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Protective effects of Bidens pilosa alleviates against alcohol—induced hepatic steatosis in rats: In vivo studies and in silico analysis

Silitonga,

Sidabutar,

Pranoto

et al. 2024

Pharmacological Research - Modern Chinese Medicine

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Protective effects of Bidens pilosa alleviates against alcohol—induced hepatic steatosis in rats: In vivo studies and in silico analysis

Silitonga,

Sidabutar,

Pranoto

et al. 2024

Pharmacological Research - Modern Chinese Medicine

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Pharmacological and Therapeutic Biofunction of Dendrobium nobile: A Critical Review

Jain,

Sarsaiya,

Gong

et al. 2024

Natural Product Communications

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Dendrobium nobile ( D. nobile), an orchid species deeply rooted in traditional medicine, has garnered considerable attention for its potential pharmacological and therapeutic properties. This critical review provides a comprehensive analysis of the bioactive compounds present in D. nobile and explores their diverse pharmacological effects. The phytochemistry of D. nobile has been discussed, highlighting its major constituents and bioactive compounds with specific properties. The pharmacological profile of D. nobile has been investigated in various domains. Notably, its strong antioxidant activity and ability to scavenge free radicals have been shown to support its immune-modulating, anti-inflammatory, and neuroprotective effects. Intriguingly, these orchids display promising anticancer, antidiabetic, cardiovascular, renoprotective, hepatoprotective, and wound-healing properties. The mechanisms underlying these effects were explored, including molecular pathways and signalling cascades. However, factors influencing its chemical composition, such as environmental conditions, cultivation techniques, and postharvest processing, must be considered for consistent therapeutic outcomes. The safety and toxicity profiles derived from acute and chronic toxicity studies were examined. In future studies, exploring the untapped therapeutic potential and elucidating the intricate mechanisms of action are promising. This review underscores the pharmacological richness of D. nobile, revealing its potential to contribute to modern medicine while emphasising the need for further investigation to harness its full therapeutic benefits.

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The Chemical Structure and Pharmacological Activity of Sesquiterpenoids in Dendrobium Sw.

Li,

Gao,

et al. 2024

Molecules

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Dendrobium is one of the most important orchids with high medicinal value. The diverse pharmacological activities of Dendrobium are attributed to its rich content of secondary metabolites. Due to the high variety and content of sesquiterpenoids in Dendrobium, more studies on their pharmacological activities have been reported. More than 100 sesquiterpenoids have been isolated from the roots and stems of Dendrobium, and these compounds have been shown to play important roles in a variety of diseases. However, there is a lack of systematic summarization of the chemical structures and pharmacological activities of sesquiterpenoids in Dendrobium Sw. Here, we reviewed the chemical structures of the sesquiterpenoids in Dendrobium plants, classified them according to the skeleton types, and summarized their pharmacological activities and mechanisms of action, with a view to laying a foundation for future studies on their pharmacological activity mechanisms and rational clinical applications.

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Sesquiterpenoids of Dendrobium nobileLindl. aqueous extract for inhibition alcoholic liver injury through RTK/ELF4regulated inflammation in mouse hepatic macrophages

Cited by 3 publications

References 47 publications

Protective effects of Bidens pilosa alleviates against alcohol—induced hepatic steatosis in rats: In vivo studies and in silico analysis

Protective effects of Bidens pilosa alleviates against alcohol—induced hepatic steatosis in rats: In vivo studies and in silico analysis

Pharmacological and Therapeutic Biofunction of Dendrobium nobile: A Critical Review

The Chemical Structure and Pharmacological Activity of Sesquiterpenoids in Dendrobium Sw.

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