Population dynamics with complex biological interactions, accounting for uncertainty quantification, are critical for many application areas. However, due to the complexity of biological systems, the mathematical formulation of the corresponding problems faces the challenge that the corresponding stochastic processes should, in most cases, be considered in bounded domains. We propose a model based on a coupled system of reflecting Skorokhod‐type stochastic differential equations with jump‐like exit from a boundary. The setting describes the population dynamics of active and passive populations. As main working techniques, we use compactness methods and Skorokhod's representation of solutions to SDEs posed in bounded domains to prove the well‐posedness of the system. This functional setting is a new point of view in the field of modeling and simulation of population dynamics. We provide the details of the model, as well as representative numerical examples, and discuss the applications of a Wilson–Cowan‐type system, modeling the dynamics of two interacting populations of excitatory and inhibitory neurons. Furthermore, the presence of random input current, reflecting factors together with Poisson jumps, increases firing activity in neuronal systems.