2023
DOI: 10.33187/jmsm.1069549
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Set-Valued Control of Cancer by Combination Chemotherapy

Abstract: Mathematical model of ordinary differential equations is considered to analyze pharmacokinetics of multi chemotherapeutic drugs, and their pharmacodynamic effects on homogeneous tumors. Set-valued analysis is used to design protocols of drugs administration, and applied to decrease tumors density under their carrying capacity of Gompertz growth and converges to zero.

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Cited by 3 publications
(2 citation statements)
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“…[17] Checks the controllability and observability for a mathematical model of immunotherapy and chemotherapy for cancer. [18] Uses set-valued analysis to approach the problem of decreasing and asymptotically stabilizing tumor cells, by anti-angiogenic therapy combined with radiotherapy, as well as in in [19] by tumor-immune with chemotherapy, so as in [20,21] by anti-angiogenic therapy with chemotherapy, while in [22] chemotherapy is used alone. [23] Studies the optimal effects of immuno-chemotherapy in the presence of gene therapy.…”
Section: Introductionmentioning
confidence: 99%
“…[17] Checks the controllability and observability for a mathematical model of immunotherapy and chemotherapy for cancer. [18] Uses set-valued analysis to approach the problem of decreasing and asymptotically stabilizing tumor cells, by anti-angiogenic therapy combined with radiotherapy, as well as in in [19] by tumor-immune with chemotherapy, so as in [20,21] by anti-angiogenic therapy with chemotherapy, while in [22] chemotherapy is used alone. [23] Studies the optimal effects of immuno-chemotherapy in the presence of gene therapy.…”
Section: Introductionmentioning
confidence: 99%
“…The originality of this paper is that the set-valued methods developed to feedback stabilize the tumor density u(t), u(t) → 0, when t → ∞, subject to the odes [15,16,17]…”
Section: Introductionmentioning
confidence: 99%