SETAC globalization

Kendall, Ron J.

doi:10.1002/etc.5620111101

Cited by 3 publications

(2 citation statements)

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“…SLC5A5 activity is sensitive to the small molecule perchlorate, a common aquatic pollutant that is used as an oxidizer for consumer and industrial applications such as propellants, fireworks, airbags, matches, and flares (Kendall & Smith, 2006; Urbansky et al, 2001). Perchlorate contaminates drinking water in many places and many commonly consumed food products (Murray et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Evolution and developmental expression of the sodium–iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology

Petersen

Small

Yan

et al. 2022

Evolutionary Applications

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The vertebrate sodium-iodide symporter (NIS or SLC5A5) transports iodide into the thyroid follicular cells that synthesize thyroid hormone. The SLC5A protein family includes transporters of vitamins, minerals, and nutrients. Disruption of SLC5A5 function by perchlorate, a pervasive environmental contaminant, leads to human pathologies, especially hypothyroidism. Perchlorate also disrupts the sexual development of model animals, including threespine stickleback (Gasterosteus aculeatus) and zebrafish (Danio rerio), but the mechanism of action is unknown. To test the hypothesis that SLC5A5 paralogs are expressed in tissues necessary for the development of reproductive organs, and therefore are plausible candidates to mediate the effects of perchlorate on sexual development, we first investigated the evolutionary history of Slc5a paralogs to better understand potential functional trajectories of the gene family. We identified two clades of slc5a paralogs with respect to an outgroup of sodium/choline cotransporters (slc5a7); these clades are the NIS clade of sodium/ iodide and lactate cotransporters (slc5a5, slc5a6, slc5a8, slc5a8, and slc5a12) and the SGLT clade of sodium/glucose cotransporters (slc5a1, slc5a2, slc5a3, slc5a4, slc5a10, and slc5a11). We also characterized expression patterns of slc5a genes during development. Stickleback embryos and early larvae expressed NIS clade genes in connective tissue, cartilage, teeth, and thyroid. Stickleback males and females expressed slc5a5 and its paralogs in gonads. Single-cell transcriptomics (scRNA-seq) on zebrafish sex-genotyped gonads revealed that NIS clade-expressing cells included germ cells (slc5a5, slc5a6a, and slc5a6b) and gonadal soma cells (slc5a8l). These results are consistent with the hypothesis that perchlorate exerts its effects on sexual development by interacting with slc5a5 or its paralogs in reproductive tissues. These findings show novel expression domains of slc5 genes in stickleback and zebrafish, which suggest similar functions across vertebrates including humans, and provide candidates to mediate the effects of perchlorate on sexual development.

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Section: Introductionmentioning

confidence: 99%

Evolution and developmental expression of the sodium–iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology

Petersen

Small

Yan

et al. 2022

Evolutionary Applications

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“…This momentous stage in our Society's history has not been reached quickly. Discussions and preparations for a unified global society began in earnest in 1998, but the idea of a global society was mentioned in John Giesy's 1990 presidential editorial [1] and was the subject of Ron Kendall's 1992 presidential editorial [2]. During the past two and one‐half years, the governing bodies of each SETAC organization (geographic units in the new parlance) collaborated to develop a global structure for SETAC that would be better positioned to meet the needs of its membership worldwide.…”

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confidence: 99%

A new era for setac: The challenges of globalization

President

2002

Environmental Toxicology and Chemistry

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Emerging Water Pollutants from Food and Packaging Industry

Ayub

Rehman

Umair

et al. 2022

Emerging Water Pollutants: Concerns and Remediation Technologies

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Rapid industrialization and continuous mechanization of the food industry have increased waste production which is a source of various kinds of contaminants especially emerging water pollutants (EWPs). The industry of food (agriculture and processed food) and packaging industry are major sources of these emerging pollutants. Agrochemicals are also a source of pollutants which are contaminating the food chain and underground water. The dairy and meat industries are source of excess antibiotics, lactating hormones, medicines (via exudates and effluents), animal fats, acids, sludge, organic compounds and persisting chemicals in meat and milk. The food processing industry can also contribute various pollutants, like dyes, preservatives, sanitizing and disinfecting agents, as well as alcoholic and phenolic residues from the beverage and wine industries.The food packaging industry is also a major source of food preservatives, dyes, glue, and non-recyclable/one-time-use materials (plastic and polystyrene), which can be broken down into micro/nano plastics leading their way to water reserves and ultimately to the human food chain. Effluents of the food and packaging industry are rich in organic material and can support the growth of various pathogenic bacteria and fungi which can become a source of EWPs and can compromise human health that’s why comprehensive information about these pollutants is needed. Keeping in mind all of these aspects present draft is compiled. This chapter covers various aspects of emerging water pollutants released from food relevant industries.

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SETAC globalization

Cited by 3 publications

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Evolution and developmental expression of the sodium–iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology

Evolution and developmental expression of the sodium–iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology

A new era for setac: The challenges of globalization

Emerging Water Pollutants from Food and Packaging Industry

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