Setting the clock back: new hope for dialysis patients. Sodium thiosulphate and the regression of vascular calcifications

Piccoli, Giorgina Barbara; Torreggiani, Massimo; Gendrot, Lurlynis; Nielsen, Louise

doi:10.1007/s40620-020-00744-x

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Sodium thiosulfate (STS) has been suggested to be effective for calciphylaxis in dialysis patients, although the results of previous studies have been inconsistent [ 11 , 12 ]. Several studies have demonstrated that STS has vasodilatory and antioxidant effects and can chelate calcium deposits to form soluble calcium thiosulfate complexes, suggesting that STS may also be effective in attenuating the progression of CAC [ 13–16 ]. However, clinical studies evaluating the influence of intravenous STS on CAC progression in dialysis patients are still limited, generally with small sample sizes and inconsistent results [ 17–25 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of sodium thiosulfate on coronary artery calcification of patients on dialysis: a meta-analysis

Huang,

Duan,

et al. 2023

Renal Failure

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Coronary artery calcification (CAC) is common in dialysis patients and is associated with a higher risk of future cardiovascular events. Sodium thiosulfate (STS) is effective for calciphylaxis in dialysis patients; however, the influence of STS on CAC in dialysis patients remains unclear. This systematic review and meta-analysis were conducted to evaluate the effects of STS on CAC in patients undergoing dialysis. PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases were searched from inception to 22 March 2023 for controlled studies comparing the influence of STS versus usual care without STS on CAC scores in dialysis patients. A random effects model incorporating the potential influence of heterogeneity was used to pool the results. Nine studies, including two non-randomized studies and seven randomized controlled trials, were included in the meta-analysis. Among these, 365 patients on dialysis were included in the study. Compared with usual care without STS, intravenous STS for 3–6 months was associated with significantly reduced CAC scores (mean difference [MD] = −180.17, 95% confidence interval [CI]: −276.64 to −83.70, p < 0.001, I 2 = 0%). Sensitivity analysis limited to studies of patients on hemodialysis showed similar results (MD: −167.33, 95% CI: −266.57 to −68.09, p = 0.001; I 2 = 0%). Subgroup analyses according to study design, sample size, mean age, sex, dialysis vintage of the patients, and treatment duration of STS also showed consistent results (p for subgroup differences all > 0.05). In conclusion, intravenous STS may be effective in attenuating CAC in dialysis patients.

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Section: Introductionmentioning

confidence: 99%

Influence of sodium thiosulfate on coronary artery calcification of patients on dialysis: a meta-analysis

Huang,

Duan,

et al. 2023

Renal Failure

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“…Sodium thiosulfate alleviated the calcification progress in the iliac arteries and heart valves but failed to alleviate the abdominal aortic calcification (AAC) in patients with end-stage renal disease in a small double-blind, randomized, placebo-controlled study ( 6 ). Large-scale randomized controlled trials are still needed to confirm the potential of sodium thiosulfate to alleviate calcification ( 7 ). Thus, it is of great significance to explore the risk factors and prevent VC ( 8 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

Higher Blood Cadmium Concentration Is Associated With Increased Likelihood of Abdominal Aortic Calcification

Zheng

Liu

Jiao

et al. 2022

Front. Cardiovasc. Med.

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AimsThis study aimed to evaluate the association between blood cadmium concentration (BCC) and abdominal aortic calcification (AAC) in adults aged ≥40 years in the United States.MethodsData were obtained from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). Participants without data about BCC and AAC scores were excluded. BCC was directly measured using inductively coupled plasma mass spectrometry (ICP–MS). AAC scores were quantified by the Kauppila scoring system, and severe AAC was defined as an AAC score >6. Weighted multivariable regression analysis and subgroup analysis were conducted to explore the independent relationship between cadmium exposure with AAC scores and severe AAC.ResultsA total of 1,530 participants were included with an average BCC of 0.47 ± 0.02 μg/L and AAC score of 1.40 ± 0.10 [mean ± standard error (SE)]. The prevalence of severe AAC was 7.96% in the whole subjects and increased with the higher BCC tertiles (Tertile 1: 4.74%, Tertile 2: 9.83%, and Tertile 3: 10.17%; p = 0.0395). We observed a significant positive association between BCC and the AAC score (β = 0.16, 95% CI: 0.01~0.30) and an increased risk of severe AAC [odds ratio (OR) = 1.45; 95% CI: 1.03~2.04]. Subgroup analysis and interaction tests revealed that there was no dependence for the association between BCC and AAC.ConclusionBlood cadmium concentration was associated with a higher AAC score and an increased likelihood of severe AAC in adults in the United States. Cadmium exposure is a risk factor for AAC, and attention should be given to the management of blood cadmium.

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“…In a small randomized controlled study, sodium thiosulfate failed to hinder the progress of abdominal aortic calcification progress, but it positively affected calcification progress in iliac arteries and heart valves, along with several other cardiovascular functional parameters (9). Large-scale randomized controlled trials are necessary to contribute to support the use of and to gain recognition for sodium thiosulfate (10). Raggi et al found that SNF472 can significantly attenuated the progression of coronary artery calcium and aortic valve calcification in patients with end-stage kidney disease receiving hemodialysis in addition to standard care (8).…”

Section: Introductionmentioning

confidence: 99%

A narrative review of exosomes in vascular calcification

Zheng¹,

Liao²,

Xiong³

et al. 2021

Ann Transl Med

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Vascular calcification (VC) is the abnormal deposition of calcium, phosphorus, and other minerals in the vessel wall and can be commonly observed in diabetes, chronic kidney disease, and chronic inflammatory disease. It is closely associated with mortality from cardiovascular events. Traditionally, calcification is considered as a degenerative disease associated with the aging process, while increasing evidence has shown that the occurrence and development of calcification is an active biological process, which is highly regulated by multiple factors. The molecular mechanisms of VC have not yet been fully elucidated. Exosomes, as important transporters of substance transport and intercellular communication, have been shown to participate in VC. The regulation of VC by exosomes involves a number of complex biological processes, which occur through a variety of interaction mechanisms. However, the specific role and mechanism of exosomes in the process of VC are still not fully understood and require further study. This review will briefly describe the roles of exosomes in the process of VC including in the promotion of extracellular mineral deposits, induction of phenotypic conversion of vascular smooth muscle cells (VSMCs), transport of microRNA between cells, and regulation on autophagy and oxidative stress, with the aim of providing novel ideas for the clinical diagnosis and treatment of VC.

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Setting the clock back: new hope for dialysis patients. Sodium thiosulphate and the regression of vascular calcifications

Cited by 5 publications

References 8 publications

Influence of sodium thiosulfate on coronary artery calcification of patients on dialysis: a meta-analysis

Influence of sodium thiosulfate on coronary artery calcification of patients on dialysis: a meta-analysis

Higher Blood Cadmium Concentration Is Associated With Increased Likelihood of Abdominal Aortic Calcification

A narrative review of exosomes in vascular calcification

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