Sevelamer hydrochloride (Renagel®), a non‐calcaemic phosphate binder, arrests parathyroid gland hyperplasia in rats with progressive chronic renal insufficiency

Nagano, Nobuo; Miyata, Sonoe; Obana, Sachiko; Ozai, Masako; Kobayashi, Nobuhiko; Fukushima, Naoshi; Burke, Steven K.; Wada, Michihito

doi:10.1093/ndt/16.9.1870

Cited by 33 publications

(32 citation statements)

References 20 publications

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“…A study conducted by Nagano et al, (2001) on male Sprague-Dawley rats, stated a higher control concentration of 1,25(OH)2D3 (54.7±3.28 pg/ml) than the present study (23.6±4.5pg/ml).…”

Section: Discussioncontrasting

confidence: 79%

EFFECT OF SAUDI ARABIAN Capparis Cartilaginea FRUIT EXTRACTS ON SERUM PARATHYROID HORMONE AND 1α,25-DIHYDROXYVITAMIN D3 LEVELS IN RATS

Al-Goufi¹,

Sonbol²

2018

JEBAS

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Capparis cartilaginea is a shrub plant which used in traditional medicine to cure various diseases. Phytochemical analysis of Capparis cartilaginea plants extracts revealed the presence of isothiocyanates and flavonoids. A dose dependent study was designed to assess effects of Capparis cartilaginea fruit extract on serum parathyroid hormones (PTH) and 1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) levels in adult male and female Wistar rats, which could describe a regulation effect on bone metabolism. Healthy adult Wistar rats (20 female and 20 male) were treated with 1000, 2000 and 3000 mg/kg body weight (BW) of fruit extract via gavage for 6 weeks. The rats were housed under standard laboratory conditions (22±1ºC and 60% humidity) for 2 weeks prior to the experiment. Blood samples were collected to determine the level of PTH and 1α,25(OH)2D3 in serum. Results of study revealed that serum PTH levels were increased in male and female rats treated with 1000, 2000 and 3000 mg/kg body Capparis cartilaginea fruit extract. The analysis of the hormones suggested a dosedependent response in male serum PTH levels and it was significantly higher than the female PTH levels. On the other hand, all the three doses of Capparis cartilaginea fruit extract decreased 1α,25(OH)2D3 levels in both genders. The results of study indicated that Capparis cartilaginea fruit extracts have a potential to change the PTH and 1α,25(OH)2D3 hormonal levels.

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“…A study conducted by Nagano et al, (2001) on male Sprague-Dawley rats, stated a higher control concentration of 1,25(OH)2D3 (54.7±3.28 pg/ml) than the present study (23.6±4.5pg/ml).…”

Section: Discussioncontrasting

confidence: 79%

EFFECT OF SAUDI ARABIAN Capparis Cartilaginea FRUIT EXTRACTS ON SERUM PARATHYROID HORMONE AND 1α,25-DIHYDROXYVITAMIN D3 LEVELS IN RATS

Al-Goufi¹,

Sonbol²

2018

JEBAS

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“…It has been reported that increased blood urea nitrogen (BUN) and serum creatinine levels, decreased creatine clearance in doxorubicin treated Sprague-Dawley rats compared to the control [23]. Another study has indicated significant serum creatine, uric acid and BUN increase in doxorubicin-treated rats compared to the control.…”

Section: Discussionmentioning

confidence: 99%

The effect of doxorubicin on rats that received toxic and carcinogenic benzo(a)pyrene.

Coşan

Başaran²,

Güneş³

et al. 2008

Folia Histochem Cytobiol.

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“…Assessment of the Size of the Rat PTG Serial sections of the paraffin-embedded rat PTGs were cut (4 m) and stained with H&E. The maximal two-dimensional area of the right or left PTG was determined from at least ten serial sections according to the method described by Nagano et al 57 The sections were examined under a light microscope (Olympus CX40) connected to a computer. A digitizer tablet carefully traced the outside edge of the PTG, and the area inside of the circle was calculated by an image analysis system (Image J).…”

Section: Histologic Studiesmentioning

confidence: 99%

Cyclooxygenase 2 Promotes Parathyroid Hyperplasia in ESRD

Zhang

Qiu

et al. 2011

Journal of the American Society of Nephrology

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Hyperplasia of the PTG underlies the secondary hyperparathyroidism (SHPT) observed in CKD, but the mechanism underlying this hyperplasia is incompletely understood. Because aberrant cyclooxygenase 2 (COX2) expression promotes epithelial cell proliferation, we examined the effects of COX2 on the parathyroid gland in uremia. In patients with ESRD who underwent parathyroidectomy, clusters of cells within the parathyroid glands had increased COX2 expression. Some COX2-positive cells exhibited two nuclei, consistent with proliferation. Furthermore, nearly 78% of COX2-positive cells expressed proliferating cell nuclear antigen (PCNA). In the 5/6-nephrectomy rat model, rats fed a high-phosphate diet had significantly higher serum PTH levels and larger parathyroid glands than sham-operated rats. Compared with controls, the parathyroid glands of uremic rats exhibited more PCNA-positive cells and greater COX2 expression in the chief cells. Treatment with COX2 inhibitor celecoxib significantly reduced PCNA expression, attenuated serum PTH levels, and reduced the size of the glands. In conclusion, COX2 promotes the pathogenesis of hyperparathyroidism in ESRD, suggesting that inhibiting the COX2 pathway could be a potential therapeutic target. Secondary hyperparathyroidism (SHPT) is one of the most common abnormalities of mineral metabolism in patients with chronic kidney disease (CKD), characterized by hyperplasia of the parathyroid gland (PTG). 1 It is well documented that increased parathyroid hormone (PTH) contributes to bone disorders and cardiovascular complications of ESRD patients and is associated with the morbidity and mortality of this population. 2,3 Strong evidence indicates that PTG hyperplasia is positively linked to the magnitude of circulating levels of PTH, and the size of the PTG is associated with the controllability of parathyroid function in CKD patients. 4,5 The mechanism underlying PTG hyperplasia is incompletely defined.Under normal conditions, the turnover rate of the PTG is very low, and mitoses are seldom observed. 1,6 However, under certain pathologic conditions such as CKD, hyperphosphatemia, and vitamin D deficiency, increased proliferation of the PTG can be detected. 7,8 In CKD patients, the PTG shows diffuse and polyclonal proliferation at early stages of SHPT. With progression of the disease, the PTG can transform with monoclonal and aggressive proliferation. 9 -11 It is well accepted that PTG hyperplasia is associated with reduced 1,25-vitamin

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Sevelamer hydrochloride (Renagel®), a non‐calcaemic phosphate binder, arrests parathyroid gland hyperplasia in rats with progressive chronic renal insufficiency

Cited by 33 publications

References 20 publications

EFFECT OF SAUDI ARABIAN Capparis Cartilaginea FRUIT EXTRACTS ON SERUM PARATHYROID HORMONE AND 1α,25-DIHYDROXYVITAMIN D3 LEVELS IN RATS

EFFECT OF SAUDI ARABIAN Capparis Cartilaginea FRUIT EXTRACTS ON SERUM PARATHYROID HORMONE AND 1α,25-DIHYDROXYVITAMIN D3 LEVELS IN RATS

The effect of doxorubicin on rats that received toxic and carcinogenic benzo(a)pyrene.

Cyclooxygenase 2 Promotes Parathyroid Hyperplasia in ESRD

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