Seven skeletal muscles rich in slow muscle fibers may function to sustain neutral position in the rodent hindlimb

Hitomi, Yoshiaki; Kizaki, Takako; Watanabe, Sumiko; Matsumura, George; Fujioka, Yasunori; Haga, Shukoh; Izawa, Tetsuya; Taniguchi, Naoyuki; Ohno, Hideki

doi:10.1016/j.cbpc.2004.09.021

Cited by 31 publications

(22 citation statements)

References 12 publications

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“…This is because, to date, investigations of skeletal muscle characteristics in the ob/ob mouse have been carried out mostly [7][8][9] on hindlimb muscles, such as extensor digitorum longus (EDL) and soleus (SOL), and involved histochemistrybased fibre typing, a method unable to detect fibres expressing the IId/x myosin heavy chain (MHC) isoform (type IID/X fibres) and fibres co-expressing several MHC isoforms (hybrid fibres). 1 In this study, we addressed the aforementioned cognitive gaps by examining, at whole muscle and single fibre level, several morphological and biochemical characteristics of three skeletal muscles, differing with respect to anatomical location, physiological function, and fibre type compositionFsternomastoid (SM) (fast-twitch neck muscle known to assist in head/neck rotation and respiration 10 ), EDL (predominantly fast-twitch hindlimb muscle; locomotor 11 ), and SOL (mixed slow/fast-twitch hindlimb muscle; primarily postural 11,12 )Ffrom adult (18-22 weeks) ob/ob mouse and its lean control. The characteristics examined include muscle mass and cross-sectional area (CSA), fibre CSA, total protein content, MHC (myofibrillar marker of contractile kinetics) content, MHC isoform (MHC i ) composition, fibre type composition, and lactate dehydrogenase isoenzyme (LDH iso ; cellular metabolic marker) composition.…”

Section: Introductionmentioning

confidence: 99%

Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse

et al. 2009

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Background: Knowledge of the morphological and biochemical alterations occurring in skeletal muscles of obese animals is relatively limited, particularly with respect to non-limb muscles and relationship to fibre type. Objective: Sternomastoid (SM; fast-twitch), extensor digitorum longus (EDL; fast-twitch), and soleus (SOL; mixed) muscles of ob/ob mouse (18-22 weeks) were examined with respect to size (mass, muscle mass-to-body mass ratio, cross-sectional area (CSA)), fibre CSA, protein content, myosin heavy chain (MHC) content, MHC isoform (MHC i ) composition, MHC i -based fibre type composition, and lactate dehydrogenase isoenzyme (LDH iso ) composition. Results: Compared with (control) muscles from lean mice, all the three muscles from ob/ob mice were smaller in size (by 13-30%), with SM and EDL being the most affected. The CSA of IIB and IIB þ IID fibres (the predominant fibre types in SM and EDL muscles) was markedly smaller (by B30%) in ob/ob mice, consistent with differences in muscle size. Total protein content (normalised to muscle mass) was significantly lower in EDL (À9.7%) and SOL (À14.1%) muscles of ob/ob mice, but there were no differences between SM, EDL, and SOL muscles from the two animal groups with respect to MHC content (also normalised to muscle mass). Electrophoretic analyses of MHC i composition in whole muscle homogenates and single muscle fibres showed a shift towards slower MHC i content, slower MHC i containing fibres, and a greater proportion of hybrid fibres in all the three muscles of ob/ob mice, with a shift towards a more aerobic-oxidative phenotype also observed with respect to LDH iso composition. Conclusion: This study showed that SM, EDL, and SOL muscles of ob/ob mice display size reductions to an extent that seems to be largely related to fibre type composition, and a shift in fibre type composition that may result from a process of structural remodelling, as suggested by the increased proportion of hybrid fibres in muscles of ob/ob mice.

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Section: Introductionmentioning

confidence: 99%

Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse

et al. 2009

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“…In cases of sectioning-reinsertion, controls by radiopaque markers show suture failures in 75% to 90% of the cases [9,12].…”

Section: Discussionmentioning

confidence: 97%

Capsular closure and piriformis preservation to prevent dislocation after total hip arthroplasty through the minimal posterior approach. Comparative series of 196 patients

Prigent¹

2006

Interact Surg

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Purpose of the study: This study analyzes the incidence on hip dislocation of a posterior minimally invasive approach that combines the suture of the capsular joint and the preservation of the piriformis muscle.Material and methods: A first prospective series of 98 patients having undergone hip prosthesis by a posterior minimally invasive approach that combines piriformis preservation and capsular closure is analyzed regarding 7 criteria: age, weight, duration of the intervention, piriformis integrity and quality of the capsular closure at the end of the intervention, radiological position of the implants, and rate of dislocation at M12. This series is compared to another consecutive series of 98 hip prostheses performed by the same operator, by posterior access, consisting in capsular resection and cutting of the piriformis reinserted on the trochanter.Results: The two series were identical regarding patients' age and weight. The minimally invasive surgery lasted 20 minutes more than the other intervention. In both interventions, no effect was observed on the radiological position of the implants. The rate of hip dislocation after twelve months was significantly improved by the capsular closure combined with piriformis preservation (2.9% vs 0%).Discussion: The restoration of the capsular plane has been the subject of numerous works. The techniques described had some variants, with a related rate of dislocation less than 1%.Piriformis preservation participates in the joint coaptation. This muscle is stretched out during the first step of the dislocating movement.The presented series highlights the benefit of combining a capsular flap truly suturable and the preservation of the piriformis muscle aimed at creating a ''hammock'', passive and active at the same time, at the upper posterior part of the joint, a strategic area with a high related risk of dislocation.

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“…In agreement with higher functional demands by weight bearing exercises, increased functional gain from weight bearing compared to non-weight bearing hip rehabilitation has been documented (Tsukagoshi et al, 2014). The high content of sensory elements and slow twitch fibers (Stillman, 2000;Hitomi et al, 2005) supports a finely adjusting function of gluteus minimus. A structural need for a differentiated gluteus minimus recruitment in weight bearing may be provided by the physiological incongruence of the hip joint (Menschik, 1997) which provides space for translations of the femoral head (Harding et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Of all hip abductors, gluteus minimus contains the highest percentage of slow twitch fibers (Hitomi et al, 2005) and muscle spindles (Stillman, 2000), rendering the muscle most appropriate for finely adjusted, low force, long-lasting activities. Differential activation has been observed between gluteus minimus and gluteus medius (Wilson et al, 1976;Kumagai et al, 1997) and between the superficial and deep regions of the gluteus medius muscle (Kumagai et al, 1997) suggesting that task-specific muscle activity does not only include differentiation between adjacent abductor muscles but also between deep and superficial muscles and muscle regions.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of gluteus medius and minimus activity in weight bearing and non-weight bearing exercises by M-mode ultrasound imaging

et al. 2015

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Seven skeletal muscles rich in slow muscle fibers may function to sustain neutral position in the rodent hindlimb

Cited by 31 publications

References 12 publications

Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse

Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse

Capsular closure and piriformis preservation to prevent dislocation after total hip arthroplasty through the minimal posterior approach. Comparative series of 196 patients

Differentiation of gluteus medius and minimus activity in weight bearing and non-weight bearing exercises by M-mode ultrasound imaging

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