Seven Ways to Preserve the Miracle of Antibiotics

Bartlett, John G.; Gilbert, David N.; Spellberg, Brad

doi:10.1093/cid/cit070

Cited by 392 publications

(334 citation statements)

References 33 publications

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“…In support of the choice of this intervention, several studies have shown that a shorter duration of antibiotic treatment is equivalent to the traditional longer durations. 13 We made the decision to restrict the number of concurrently administered antimicrobials mainly because previous treatments are not necessarily discontinued on initiation of a new antibiotic.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial stewardship across 47 South African hospitals: an implementation study

Brink

Messina

Feldman

et al. 2016

The Lancet Infectious Diseases

179

194

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Section: Discussionmentioning

confidence: 99%

Antimicrobial stewardship across 47 South African hospitals: an implementation study

Brink

Messina

Feldman

et al. 2016

The Lancet Infectious Diseases

179

194

View full text Add to dashboard Cite

“…However, the use of microfuidics for the filtering of blood may be infeasible due to he large blood volumes and flow rates required for processing, relative to the volumes and flow rates ammenable to microfluidic processing. While NP targeting has been long appreciated, and has been employed in high-priced cancer treatments, the translation of NP-antibiotic constructs has been hindered due to the high cost of most NP formation processes relative to the low price of antibiotic therapies (Bartlett et al 2013;Piddock 2012). In addition, the use of microfluidics for the filtering of blood may be unfeasible due to the large blood volumes and flow rates required for processing, relative to the volumes and flow rates permitted in microfluidic devices.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle targeting of Gram-positive and Gram-negative bacteria for magnetic-based separations of bacterial pathogens

Yang

Wilson

et al. 2017

Appl Nanosci

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Antimicrobial resistance is a healthcare problem of increasing significance, and there is increasing interest in developing new tools to address bacterial infections. Bacteria-targeting nanoparticles hold promise to improve drug efficacy, compliance, and safety. In addition, nanoparticles can also be used for novel applications, such as bacterial imaging or bioseperations. We here present the use of a scalable block-copolymer-directed self-assembly process, Flash NanoPrecipitation, to form zinc(II)-bis(dipicolylamine) modified nanoparticles that bind to both Grampositive and Gram-negative bacteria with specificity. Particles have tunable surface ligand densities that change particle avidity and binding efficacy. A variety of materials can be encapsulated into the core of the particles, such as optical dyes or iron oxide colloids, to produce imageable and magnetically active bacterial targeting constructs. As a proof-of-concept, these particles are used to bind and separate bacteria from solution in a magnetic column. Magnetic manipulation and separation would translate to a platform for pathogen identification or removal. These magnetic and targeted nanoparticles enable new methods to address bacterial infections.

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“…Some pollutants groups have received special attention since the late 90s [4], due to correlations between the development and rapid expansion of antibiotic resistance and their total consumption and occurrence in the environment [4,5]. According to Bartlett et al [88], the resistance within all microbial classes continues to grow by a natural evolution driven by the massive use of agents that apply selective antimicrobial pressure, and pharmaceutical development that had previously kept men ahead of resistance is now stalled due to economic and regulatory barriers.…”

Section: Removal Of Pharmaceuticals By Fe 3 O 4 @C Core-shell Nanoparmentioning

confidence: 99%

Synthesis and Potential Adsorption of Fe3O4@C Core-Shell Nanoparticles for to Removal of Pollutants in Aqueous Solutions: A Brief Review.

Mm¹,

Macuvele²,

Müller³

et al. 2017

J Adv Chem Eng

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Journal of Advanced Chemical EngineeringLima et al., J Adv Chem Eng 2017, 7:1 DOI: 10.4172/2090 Volume AbstractCore-shell Fe 3 O 4 @C nanoparticles consist of a magnetic core and carbon coating, and exhibit high adsorptive capacity, easy magnetic separation and reusability. Due to these properties, core-shell Fe 3 O 4 @C nanoparticles have great potential application in adsorption, separation and wastewater treatment. Magnetic separation based on the super paramagnetic Fe 3 O 4 has received considerable attention and is widely used for the removal of dye, oil pharmaceuticals and metals from water due to its high efficiency and economic viability. Therefore, the main characteristics of the core-shell Fe 3 O 4 @C nanoparticles, the different types of synthesis, as well as the main applications for the removal of water pollutants were reviewed. In this brief review, an overview of the basic properties of the Fe 3 O 4 @C core-shell nanoparticles are given, and the most important and more frequently used methods for the synthesis of Fe 3 O 4 @C core-shell nanoparticles have been summarized along with the description of its adsorbent application potential.

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Seven Ways to Preserve the Miracle of Antibiotics

Cited by 392 publications

References 33 publications

Antimicrobial stewardship across 47 South African hospitals: an implementation study

Antimicrobial stewardship across 47 South African hospitals: an implementation study

Nanoparticle targeting of Gram-positive and Gram-negative bacteria for magnetic-based separations of bacterial pathogens

Synthesis and Potential Adsorption of Fe3O4@C Core-Shell Nanoparticles for to Removal of Pollutants in Aqueous Solutions: A Brief Review.

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