Seventeen-year-old sexually active male with rash

Boyd, Anne H.; Mills, David A.; Hook, Kristen P.; Kaila, Rahul

doi:10.1016/j.ajem.2015.08.043

Cited by 7 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Newell et al found phenytoin, carbamazepine, and phenobarbital to be the most common culprits, while other pediatric DRESS series confirmed lamotrigine and phenytoin, respectively, as the most common etiologies . In the pediatric literature, antibiotics are being increasingly reported as the primary etiology with vancomycin, amoxicillin‐clavulanic acid, and trimethoprim‐sulfamethoxazole most commonly reported …”

Section: Discussionmentioning

confidence: 99%

“…6,9,34 In the pediatric literature, antibiotics are being increasingly reported as the primary etiology with vancomycin, amoxicillin-clavulanic acid, and trimethoprim-sulfamethoxazole most commonly reported. [6][7][8][9][12][13][14][15][16][17][18][19]21 Patients developed symptoms and presented to physicians at 4 and 5 weeks, respectively, after the inciting medication. Previous series reported an earlier onset of antibiotic-induced pediatric DRESS with an average time to symptoms of approximately 6-11 days after antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Understanding of DRESS in children is based upon case reports and small case series. The most commonly implicated drugs in children include antibiotics, namely trimethoprim‐sulfamethoxazole and vancomycin, followed by antiepileptic medications, such as lamotrigine, carbamazepine, and phenytoin . Ibuprofen, nevirapine, raltegravir, acetylsalicylic acid, griseofulvin, fluoxetine, and sulthiamine have been associated triggers in single pediatric case reports .…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly implicated drugs in children include antibiotics, namely trimethoprim-sulfamethoxazole and vancomycin, followed by antiepileptic medications, such as lamotrigine, carbamazepine, and phenytoin. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Ibuprofen, nevirapine, raltegravir, acetylsalicylic acid, griseofulvin, fluoxetine, and sulthiamine have been associated triggers in single pediatric case reports. 3,[26][27][28][29][30][31] In addition, Sasidharanpillai et al found DRESS to occur more promptly after antibiotic therapy, averaging about one week after drug initiation, compared to over three weeks after antiepileptic therapy.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Oberlin

Rahnama‐Moghadam

Alomari

et al. 2019

Pediatric Dermatology

View full text Add to dashboard Cite

Background Pediatric Drug reaction with eosinophilia and systemic symptoms (DRESS) is an uncommon disease that can be difficult to diagnose. This case series and literature review highlights the clinical features of pediatric DRESS and underscores the differential diagnoses, culprit medications, and need for clinical follow‐up to detect associated autoimmune sequelae. Objective To describe the clinical and laboratory features of pediatric DRESS, identify associated culprit medications, and discuss the natural history of disease. Methods Ten cases of pediatric DRESS were identified in the electronic medical record by searching the inpatient dermatology consultation list at Indiana University between 2013 and 2018. Clinical and laboratory data were collected including demographics, differential diagnoses, culprit medications, resolution of disease, and autoimmune sequelae. Results Pediatric patients with DRESS presented at a mean age of 11.5 years and demonstrated a mean time from drug initiation to onset of symptoms of 4 weeks. The most common inciting drugs included antibiotics (62.5%) followed by antiepileptics (37.5%). Rash and transaminitis resolved by 3 weeks, and 20% of patients, all female, developed autoimmune sequelae including Hashimoto's thyroiditis and an undifferentiated connective tissue disorder and occurred at an average of 14.5 weeks after diagnosis. Limitations This was a small retrospective study of an uncommon clinical diagnosis at a single institution. Conclusions Pediatric DRESS was most commonly caused by antibiotics which are being increasingly recognized in the literature as the predominant culprit medications. The development of autoimmune sequelae is a notable consequence that can present weeks after illness and may preferentially affect female patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Oberlin

Rahnama‐Moghadam

Alomari

et al. 2019

Pediatric Dermatology

View full text Add to dashboard Cite

show abstract

“…The exact mechanism of DRESS is yet unknown, but it can be figured based on the etiology of genetics and viral reactivation (Figure 2). 59,60 Based on the report and publication, 23 cases of DRESS caused by sulfonamide have been reported. 61 So far, there has been no specific treatment for DRESS sufferers.…”

Section: Dressmentioning

confidence: 99%

Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity

Asyraf¹,

Kusnadi²,

Stefanus³

et al. 2022

DHPS

View full text Add to dashboard Cite

Drug hypersensitivity is an inflammatory or immune reaction induced by drugs. It can be fatal if not appropriately treated and cause the risk of long-term complications. Sulfonamides are classified as antimicrobial drugs with a broad spectrum effective for gram-positive and gram-negative bacteria. This antibacterial agent works by competitively inhibiting folic acid synthesis, which prevents the growth and proliferation of microorganisms. In its use as antibiotics, sulfonamides can also cause adverse reactions in specific individuals. It has been widely reported that sulfonamide antimicrobials cause hypersensitivity reactions mediated by IgE or T cells. This review identifies symptoms or signs that can appear, as well as genes associated with sulfonamide hypersensitivity reactions, as sulfonamide may cause hypersensitivity in the form of uveitis, skin rash, Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), parotitis, angioedema, drug reaction with eosinophilia and systemic symptoms (DRESS), and pruritus. In addition, several genes were found to be associated with sulfonamide hypersensitivity, including HLA-A29, HLA-B12, HLA-DR7, HLA-B44, and HLA A*11:01.

show abstract

Cotrimoxazole

2016

Reactions Weekly

View full text Add to dashboard Cite

Seventeen-year-old sexually active male with rash

Cited by 7 publications

References 8 publications

Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity

Cotrimoxazole

Contact Info

Product

Resources

About