Effective diagnostic and monitoring systems are highly needed in the building and infrastructure sector, to provide a comprehensive assessment of the structural health state and improve the maintenance and restoration planning. Vibration-based techniques, and especially ambient vibration testing, have proved to be particularly suitable for both periodic and continuous monitoring of existing structures. As a general requirement, permanent systems must include a sensing network able to run a continuous surveillance and provide reliable analyses based on different information sources. e variability in the environmental and operating conditions needs to be accounted for in designing such a sensor network, but it is mainly the structural typology that governs the optimal sensor placement strategy. Architectural heritage consists of a great variety of buildings and monuments that significantly differ from each other in terms of typology, historic period, construction techniques, and materials. In this paper, the main issues regarding seismic protection and analysis of the modern architectural heritage are introduced and applied to one of the vaulted structures built by Pier Luigi Nervi in the Turin Exhibition Centre. e importance of attaining an adequate level of knowledge in historic structures is also highlighted. After an overview of the Turin Exhibition Centre and its construction innovations, this paper focuses on Hall B, describing the structural design conceived by Pier Luigi Nervi. A seismic assessment of the structures of Hall B is then presented, considering the potential seismic damage to nonstructural elements. Subsequently, the application of an optimal sensor placement strategy is described with reference to two different scenarios: the first one corresponding to the undamaged structure and the second one that considers a possible damage to the infill walls. Finally, a novel damage-scenario-driven sensor placement strategy based on a combination of the two above mentioned is proposed and discussed. One of the major conclusions drawn from the analyses performed is that nonstructural elements undergoing seismic damage or degradation may significantly affect the global dynamic response and consequently the optimal sensing configurations.