Several Lipid-Related Gene Polymorphisms Interact with Overweight/Obesity to Modulate Blood Pressure Levels

Abstract

Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaII hepatic lipase gene (LIPC) −250G > A, endothelial lipase gene (LIPG) 584C > T, methylenetetrahydrofolate reductase (MTHFR) 677C > T, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP) rs3757354, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T > C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 978 normal weight and 751 overweight/obese subjects. The interactions were detected by factorial regression analysis. The genotypes of ACAT-1 AC, LIPC GA and AA, and SCARB1 TT; LDL-R A-A- and LIPC GA; and SCARB1 TT were interacted with overweight/obesity to increase systolic, diastolic blood pressure (SBP, DBP) and pulse pressure (PP) levels; respectively. The genotypes of ACAT-1 CC; ACAT-1 AA and CC were interacted with overweight/obesity to decrease SBP, PP levels (p < 0.01–0.001); respectively. The differences in blood pressure levels between normal weight and overweight/obese subjects might partly result from different interactions of several SNPs and overweight/obesity.

Effect of ATP-binding Cassette Transporter A1 (ABCA1) Gene Polymorphisms on Plasma Lipid Variables and Common Demographic Parameters in Greek Nurses

“…According to V825I (rs2066715) gene polymorphism, Yin et al has not found association with BMI [16] although they found association with TC and apo A1 [17] in normal weight subjects and LDL-C and apo B in overweight. Cao et al [18] reported that the V825I polymorphism in the ABCA1 gene is associated with HDL-C and apo A1 concentrations in males Han, and serum TC concentrations in the Bai Ku Yao populations.…”

Interactions of several genetic polymorphisms and alcohol consumption on blood pressure levels

“…A total of 1,224 unrelated participants of Bai Ku Yao who reside in Lihu and Baxu villages in Nandan County, Guangxi Zhuang Autonomous Region, China were recruited by a stratified randomized sampling . There were 616 nondrinkers (male/female, 414/202) and 608 drinkers (male/female, 414/196).…”

The MYLIP p.N342S polymorphism is associated with response to lipid-lowering therapy in Brazilian patients with familial hypercholesterolemia

“…Other recent studies demonstrated the association of the p.N342S polymorphism with cholesterol levels in a Mexican dyslipidemic sample and a possible contribution of MYLIP variants to circulating LDL-C levels 17 , 31 . In addition, other studies have reported an association of MYLIP polymorphisms with phenotypes such as blood pressure and obesity 32 – 34 . Interestingly, patients from our sample had equal baseline TC and LDL-C levels according to MYLIP genotypes.…”