Severe 25(OH)vitamin-D deficiency: A risk factor for development of gestational diabetes mellitus

Rajput, Rajesh; Vohra, Shweta; Nanda, Smiti; Rajput, Meena

doi:10.1016/j.dsx.2019.01.004

Cited by 16 publications

(13 citation statements)

References 11 publications

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“…This is in line with findings of a recent large case‐control study among a cohort (116 GDM cases and 303 controls) of pregnant women in neighboring Saudi Arabia, which reported that women with vitamin D deficiency in early pregnancy had a 2.87 higher risk of subsequent GDM 11 . As mentioned above, several studies showed a significant association between GDM and vitamin D deficiency/vitamin D level 7–11 . Moreover, a recent meta‐analysis of 20 studies including 9209 participants reported that pregnant women who had vitamin D deficiency had a significantly increased risk for GDM 19 .…”

Section: Discussionsupporting

confidence: 88%

“…Published evidence on the relationship between vitamin D level and the occurrence of GDM is not yet conclusive. Many studies have shown a significant association between GDM and vitamin D level, 7–11 but other studies have shown no significant difference in this level between women with GDM and a control group of women 12–15 . Moreover, there are no published data on the association between vitamin D levels and GDM in Africa (including Sudan).…”

Section: Introductionmentioning

confidence: 99%

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Maternal early pregnancy serum level of 25‐Hydroxyvitamin D and risk of gestational diabetes mellitus

Al-Shafei

Rayis

Mohieldein

et al. 2020

Intl J Gynecology & Obste

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Objective To assess if early pregnancy (≤14 weeks of gestation) 25‐hydroxyvitamin D (25(OH)D) level is associated with risk of gestational diabetes mellitus (GDM). Methods A nested case‐control study (60 women in each arm) was conducted at Saad Abualila Hospital (Khartoum, Sudan) during the period of January to November 2017. Clinical and obstetrical data were gathered, 25(OH)D concentration was measured at the first prenatal visit, and a 75‐g oral glucose tolerance test was performed at 24–28 weeks of gestation. Results Compared with women without GDM, in women with GDM, the median of the 25(OH)D level was significantly lower (7.3 [interquartile range 5.7–8.8] ng/mL versus 8.4 [interquartile range 6.6–11.9] ng/mL, P=0.001). All women in the study (with and without GDM) had vitamin D deficiency (25(OH)D<20 ng/mL). The results of the logistic regression showed that a low 25(OH)D level was the only factor associated with GDM (odds ratio [OR] 0.83, 95% confidence interval [CI] 0.73–0.95, P=0.010). Women with 25(OH)D less than 6.0 ng/mL were at a higher risk of GDM (OR 3.2, 95% CI 1.29–8.12, P=0.012). Conclusion A low 25(OH)D level in early pregnancy was associated with increased risk of GDM. This finding might be useful in predicting GDM.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Maternal early pregnancy serum level of 25‐Hydroxyvitamin D and risk of gestational diabetes mellitus

Al-Shafei

Rayis

Mohieldein

et al. 2020

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…The review noted that low vitamin D levels in pregnant women are associated with higher risks of preeclampsia, gestational diabetes, and other conditions of pregnancy, as well as a number of other negative effects, including fetal growth restriction, an increased risk of preterm birth, and altered susceptibility to diseases later in life [98]. In 2020, a meta-analysis by Wang et al found that vitamin D deficiency was associated with a higher risk of GDM and negatively associated with homeostasis model assessment-insulin resistance index (HOMA-IR) [99], which is consistent with the findings of Rajesh and Xia [100][101][102]. Those studies suggest that vitamin D deficiency may increase the risk of GDM, and that supplementation during pregnancy may improve GDM [100][101][102].…”

Section: Discussionsupporting

confidence: 52%

Effects of Different Glucose-Lowering Measures on Maternal and Infant Outcomes in Pregnant Women with Gestational Diabetes: A Network Meta-analysis

Ouyang

2021

Diabetes Ther

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Introduction: A network meta-analysis was conducted to compare and rank the effects of different glucose-lowering measures on maternal and infant outcomes in pregnant women with gestational diabetes mellitus (GDM). Methods: We searched the PubMed, CNKI, Embase, Cochrane Library, Wanfang, and Weipu databases for relevant studies published between database establishment and June 2021. Study retrieval involved subject-heading and keyword searches. Randomized controlled trials (RCTs) with different glucose-lowering treatments for GDM patients were included. The Cochrane tool was used to assess bias risk. Pairwise and network meta-analyses were used to compare and rank the effects of different hypoglycemic measures on maternal and infant outcomes in pregnant women with GDM.

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“…Some studies reported that lower 25(OH)D level was associated with elevated risk of GDM. [ 15 – 19 ] But some studies reported that 25(OH)D deficiency was not associated with GDM. [ 20 – 23 ] In a case-sectional study of 723 pregnant women, of which 97% were vitamin D sufficient [25(OH)D ≥50 nmol/L], there was no difference in 25(OH)D concentration between GDM and non-GDM group.…”

Section: Discussionmentioning

confidence: 99%

Study on the levels of 25(OH)D, inflammation markers and glucose and fat metabolism indexes in pregnant women of Han nationality in Jiangsu province with gestational diabetes mellitus

et al. 2020

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The aim of this study is to investigate the levels of 25(OH)D, inflammation markers and glucose and fat metabolism indexes in pregnant women with Gestational diabetes mellitus (GDM). One hundred and ten cases GDM and 100 cases healthy pregnant women in the First People's Hospital of Lianyungang City from October 2016 to December 2018 were recruited for this observational cross-sectional study. Each participant's anthropometric and demographic data was recorded. Blood samples were collected and analyzed to determine the levels of 25(OH)D, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), fasting blood glucose, fasting blood insulin, hemoglobin A1c (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), cholesterol and triglycerides. Inflammatory markers and glucose and fat metabolism indexes were all significantly higher in the GDM group than that in the control group, while Serum 25(OH)D level in the GDM group was significantly lower. Serum 25(OH)D levels were negatively correlated with hs-CRP, while not with TNF-α. Furthermore, Serum 25(OH)D, hs-CRP and TNF-α levels were all associated with increased risk of developing GDM. Nowadays, the reports on the association between 25(OH)D level and GDM were controversial. Our results are consistent with the view that there was association between 25(OH)D level and GDM, and expand the literature by showing the roles of 25(OH)D, inflammation markers as well as glucose and fat metabolism indexes in the risk of developing GDM in the pregnant women with the low overall levels of 25(OH)D before delivery. This broadens our knowledge on the pathophysiology of GDM, which may be helpful in prevention and treatment of GDM.

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Severe 25(OH)vitamin-D deficiency: A risk factor for development of gestational diabetes mellitus

Cited by 16 publications

References 11 publications

Maternal early pregnancy serum level of 25‐Hydroxyvitamin D and risk of gestational diabetes mellitus

Maternal early pregnancy serum level of 25‐Hydroxyvitamin D and risk of gestational diabetes mellitus

Effects of Different Glucose-Lowering Measures on Maternal and Infant Outcomes in Pregnant Women with Gestational Diabetes: A Network Meta-analysis

Study on the levels of 25(OH)D, inflammation markers and glucose and fat metabolism indexes in pregnant women of Han nationality in Jiangsu province with gestational diabetes mellitus

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