Severe abdominal pain and inappropriate antidiuretic hormone secretion preceding varicella-zoster virus reactivation 10 months after autologous stem cell transplantation for acute myeloid leukaemia

Vinzio, S.; Lioure, Bruno; Enescu, I; Schlienger, J.-L.; Goichot, B.

doi:10.1038/sj.bmt.1704814

Cited by 19 publications

(1 citation statement)

References 9 publications

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“…No HHV-6 DNA was found in the CSF, but there was a sharp increase in the presence of HHV-6 DNA and antibodies in the blood that coincided with acute impairment of consciousness. In rare cases, SIADH also has been associated with other forms of encephalitides or CNS dysfunction due to other herpetic infections, such as herpes zoster and human CMV [50][51][52][53]. There also have been reports of nonviral encephalitis with SIADH-like autoimmune encephalitis and tick-borne encephalitis [54,55]; however, neither of those studies checked patients for HHV-6 infection.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Sodium Disorders in HHV-6 Encephalitis

Victoria

Phan

Agarwal

2020

Biology of Blood and Marrow Transplantation

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Human herpesvirus 6 (HHV-6) encephalitis has a high mortality rate. Among those who survive,~80% develop some type of permanent neurologic disorder. Early diagnosis and treatment may help prevent long-term sequelae. There have been several case reports as well as retrospective and prospective studies associating HHV-6 encephalitis with some form of sodium imbalance, either hyponatremia or hypernatremia; however, the exact frequency post-HCT is unknown, with reports ranging from 30% to 100%. We performed a systematic review of the literature and found 34 cases of HHV-6 encephalitis reported in conjunction with sodium imbalance that documented the timing of that imbalance relative to the onset of encephalitis. Sodium imbalance occurred before or at the onset of HHV-6 encephalitis in all but 2 cases (94%). This finding supports previous suggestions that sodium imbalance can be considered an early indicator of the potential development or presence of HHV-6 encephalitis in at-risk patient populations.

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