Severe acidosis due to 5-oxoprolinase inhibition by flucloxacillin in a patient with shoulder prosthesis joint infection

Lenz, Julia Elisabeth; Alt, Volker; Dienemann, Thomas

doi:10.5194/jbji-7-71-2022

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2024

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“…All except six cases had received paracetamol, the exceptions being cases 2, 3, 9 16, 11 78, 12 88, 13 96 14 and 98. 15 Cases 2, 3 and 88 were on vigabatrin; cases 16 and 98 were on flucloxacillin without paracetamol. Neither Rousseau's case 78 12 nor Ginz's case 96 14 was on either drug, but showed severe hyperammonaemia (and both died).…”

Section: Clinical Picturesmentioning

confidence: 99%

Pyroglutamate acidosis 2023. A review of 100 cases

Stewart

2024

Clinical Medicine

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Section: Clinical Picturesmentioning

confidence: 99%

Pyroglutamate acidosis 2023. A review of 100 cases

Stewart

2024

Clinical Medicine

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Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols

Niu,

Dong,

Niu

2024

Phytotherapy Research

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Oxidative stress is recognized to have a central role in the initiation and progression of Parkinson's disease (PD). Within the brain, neurons are particularly sensitive to oxidation due in part to their weak intrinsic antioxidant defense. Theoretically, neurons mostly depend on neighboring astrocytes to provide antioxidant protection by supplying cysteine‐containing products for glutathione (GSH) synthesis. Astrocytes and neurons possess several amino acid transport systems for GSH and its precursors. Indeed, GSH is the most abundant intrinsic antioxidant in the central nervous system. The GSH depletion and/or alterations in its metabolism in the brain contribute to the pathogenesis of PD. Noteworthy, polyphenols possess potent antioxidant activity and can augment the GSH redox system. Numerous in vitro and in vivo studies have indicated that polyphenols exhibit potent neuroprotective effects in PD. Epidemiological studies have found an association between the consumption of dietary polyphenols and a lower PD risk. In this review, we summarize current knowledge on the biosynthesis and metabolism of GSH in the brain, with an emphasis on their contribution and therapeutic potential in PD. In particular, we focus on polyphenols that can increase brain GSH levels against PD. Furthermore, some current challenges and future perspectives for polyphenol‐based therapies are also discussed.

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Flucloxacillin/Hydrocortisone

2024

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Severe acidosis due to 5-oxoprolinase inhibition by flucloxacillin in a patient with shoulder prosthesis joint infection

Abstract: Abstract. We report a case of a 64-year-old female patient with severe metabolic acidosis. Inhibition of 5-oxoprolinase by flucloxacillin was found to be the cause of the metabolic derailment.

Cited by 5 publications

References 15 publications

Pyroglutamate acidosis 2023. A review of 100 cases

Pyroglutamate acidosis 2023. A review of 100 cases

Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols

Flucloxacillin/Hydrocortisone

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