2017
DOI: 10.3325/cmj.2017.58.424
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Severe acrocyanosis precipitated by cold agglutinin secondary to infection with Mycoplasma pneumoniae in a pediatric patient

Abstract: This is the first report describing a severe form of cold agglutinin-induced acrocyanosis with cutaneous necrosis after Mycoplasma infection in a 9-year-old patient without any other severe symptoms and laboratory alterations. We also present the results of two non-invasive methods used to determine the viability of tissues, degree of tissue perfusion impairment, and the responsiveness of the microvasculature. Laser Doppler flowmetry and laser speckle contrast imaging, both suitable to measure tissue blood per… Show more

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Cited by 2 publications
(4 citation statements)
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“…4 Red fingers in association with M. pneumoniae infection have been described in only 3 patients with Raynaud's syndrome due to cryoglobulinemia. 4,5 In our case, lesions were painless, and cryoglobulins were not detected. ■…”
Section: Mycoplasma Pneumoniae-induced Red Fingersmentioning
confidence: 48%
“…4 Red fingers in association with M. pneumoniae infection have been described in only 3 patients with Raynaud's syndrome due to cryoglobulinemia. 4,5 In our case, lesions were painless, and cryoglobulins were not detected. ■…”
Section: Mycoplasma Pneumoniae-induced Red Fingersmentioning
confidence: 48%
“…While the clinical significance generally depends on both the titre of the autoantibody and the thermal amplitude, the thermal amplitude is thought to be the primary determinant as to the severity of haemolysis. 5 Cold agglutinins circulate at very low levels in much of the population, 6 but are typically insignificant due to their low titre and activity well below physiologic temperature.…”
mentioning
confidence: 99%
“…The onset of CAS secondary to M. pneumoniae occurs approximately 2 weeks following onset of primary infection symptoms. 6 While the autoantibody may persist for up to 4 months, if haemolysis does occur, it is self-limited and rarely persists for more than 3 weeks. 6 Despite the classic association between M. pneumoniae infection and CAS, this case highlights the reality that many healthcare providers are unaware of the potential for clinically significant haemolysis in these patients.…”
mentioning
confidence: 99%
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