Severe acute pancreatitis related to the use of adefovir in a liver transplant recipient

Weber, Anna-Lena; Carbonnel, F.; Simon, Nicolas; Kantelip, B; Coaquette, A.; Mantion, G.; Miguet, J. P.; Martino, Vincent Di

doi:10.1016/j.gcb.2008.01.028

Cited by 8 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Dna Polymerase Inhibitorsmentioning

confidence: 99%

“…DNA polymerase inhibitors are antiviral drugs used mainly to treat infections caused by herpes viruses (herpes simplex, varicella zoster, cytomegalovirus), but also for the treatment of hepatitis C and B [135,136]. Some agents in this class have been associated with the risk of developing AP; in particular, adefovir and famciclovir are the only ones included in the classifications discussed [135,136]. Adefovir, which is primarily used to treat hepatitis B, was classified as class Ic according to Wolfe et al because a case of severe AP associated with adefovir use in a liver transplant recipient was reported in 2008 [11].…”

Section: Dna Polymerase Inhibitorsmentioning

confidence: 99%

See 1 more Smart Citation

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Del Gaudio,

Covello,

Di Vincenzo

et al. 2023

Antibiotics

View full text Add to dashboard Cite

Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by the activation of digestive enzymes in the pancreatic tissue. The main causes of AP are cholelithiasis and alcohol abuse; less commonly, it can be caused by drugs, with a prevalence of up to 5%. Causal associations between drugs and pancreatitis are largely based on case reports or case series with limited evidence. We reviewed the available data on drug-induced AP, focusing on antimicrobial drugs and antivirals, and discussed the current evidence in relation to the classification systems available in the literature. We found 51 suspected associations between antimicrobial and antiviral drugs and AP. The drugs with the most evidence of correlation are didanosine, protease inhibitors, and metronidazole. In addition, other drugs have been described in case reports demonstrating positive rechallenge. However, there are major differences between the various classifications available, where the same drug being assigned to different probability classes. It is likely that the presence in multiple case reports of an association between acute pancreatitis and a drug should serve as a basis for conducting prospective randomized controlled trials to improve the quality of the evidence.

show abstract

Section: Dna Polymerase Inhibitorsmentioning

confidence: 99%

Section: Dna Polymerase Inhibitorsmentioning

confidence: 99%

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Del Gaudio,

Covello,

Di Vincenzo

et al. 2023

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Other drugs commonly used in the post-operative period that could cause pancreatitis in the post-liver transplant population include azathioprine/6-mercaptopurine and furosemide (42)(43)(44)(45). Despite the range of drugs that could potentially cause drug-induced pancreatitis in the liver transplant population, only one paper identified a drug (adefovir) as a potential cause for drug-induced pancreatitis following liver transplantation (46). In fact, one study identified corticosteroids as a protective factor against PEP following liver transplantation (38).…”

Section: Drugsmentioning

confidence: 99%

Acute pancreatitis following adult liver transplantation: A systematic review

Danalıoğlu

Mitchell

Singh³

et al. 2015

Turk J Gastroenterol

View full text Add to dashboard Cite

Although uncommon, acute pancreatitis is a well-recognized, but generally serious, complication following liver transplantation. In addition to being more prevalent in patients who underwent liver transplantation than in the general population, it has a more aggressive course and can be responsible for significant morbidity and mortality. The post-liver transplant population has altered anatomy, increased comorbidities, and requires a myriad of drugs. These characteristics make them different from the pre-transplant population. Despite their retrospective nature, prior studies have identified numerous etiological factors that are associated with an increased risk of acute pancreatitis following liver transplantation. These can be broadly classified into the following four categories: surgical and anatomical factors, infections, post-transplant management, and post-transplant complications. The aim of this systematic review is to assimilate the available information regarding acute pancreatitis following adult liver transplantation to describe the risk factors and natural history of the disease and to highlight possible areas for further investigation.

show abstract

Current awareness: Pharmacoepidemiology and drug safety

2008

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

show abstract

Severe acute pancreatitis related to the use of adefovir in a liver transplant recipient

Cited by 8 publications

References 8 publications

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Acute pancreatitis following adult liver transplantation: A systematic review

Current awareness: Pharmacoepidemiology and drug safety

Contact Info

Product

Resources

About