2003
DOI: 10.1016/s0140-6736(03)13652-5
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Severe acute respiratory syndrome coronavirus and viral mimicry

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Cited by 11 publications
(4 citation statements)
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“…Examples of molecular mimicry concerning SARS-CoV2 are reported [ 18 ] and this mechanism is hypothetically involved in the pathogenesis of both the acute systemic infection and the post-infective viral-related immunological consequences [ 19 , 20 ]. Previous and actual studies demonstrate that coronaviruses share molecular epitopes with human proteins (e.g., spike glycoprotein S) that play a key role to host cell invasion and escape immune response attacks, giving to the infectious agent an immune-evasive capacity [ 21 , 22 ]. SASR-CoV2 shares three sequences of six amino acids with as many brainstem human proteins and the cross-reaction between human and viral epitopes may lead to brainstem damage and respiratory failure [ 23 ].…”
Section: Discussion and Review Of The Literaturementioning
confidence: 99%
“…Examples of molecular mimicry concerning SARS-CoV2 are reported [ 18 ] and this mechanism is hypothetically involved in the pathogenesis of both the acute systemic infection and the post-infective viral-related immunological consequences [ 19 , 20 ]. Previous and actual studies demonstrate that coronaviruses share molecular epitopes with human proteins (e.g., spike glycoprotein S) that play a key role to host cell invasion and escape immune response attacks, giving to the infectious agent an immune-evasive capacity [ 21 , 22 ]. SASR-CoV2 shares three sequences of six amino acids with as many brainstem human proteins and the cross-reaction between human and viral epitopes may lead to brainstem damage and respiratory failure [ 23 ].…”
Section: Discussion and Review Of The Literaturementioning
confidence: 99%
“…Post-infectious molecular mimicry plays a crucial role in GBS, but it has been proven only in animal models for C. jejuni infection and not for other preceding viral infections; therefore, it might be unlikely as mechanism of SARS-CoV-2 related GBS. Given that, we must take into account some seminal works on viral mimicry in severe SARS respiratory syndrome involving the binding of virus antibody complexes to Fc or complement receptors on the surface of monocytes or macrophages resulting in virus uptake via receptor mediated endocytosis [ 74 ].…”
Section: Discussionmentioning
confidence: 99%
“…К настоящему времени у больных COVID-19 описаны все варианты СГБ; преобладают публикации с описанием клинических случаев развития ОВДП, ОМСАН и СМФ. Точных сведений о частоте встречаемости различных вариантов СГБ на фоне COVID-19 не приводится [23][24][25]. В большинстве публикаций авторы указывают срок 8-14 сут от момента установления диагноза COVID-19 как наиболее вероятный период развития описанных подтипов острых дизиммунных ПНП [26][27][28][29].…”
Section: острые дизиммунные пнп как осложнение Covid-19unclassified