Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review

Abstract

In recent years, the prevalence and spread of coronavirus has had a huge impact on global public health. Due to the incomplete understanding of the pathogenic mechanism of the virus, it is difficult for humans to fight against the virus quickly and effectively once the outbreak occurs. In early 2020, a novel coronavirus was discovered in Wuhan, China. Soon after, similar cases were found in other countries around the world, and the number of infected people increased rapidly. So far, the global cumulative number of infected people has exceeded 3 million, and more than 200,000 people have died, which has had a huge impact on global human health and economic development. Every outbreak of disease makes a deep impression on mankind. Herein, we summarize the virology, epidemiology, clinical manifestations, diagnosis, treatment and prevention of SARS-CoV-2, and hope that countries can control the outbreak as soon as possible to minimize the loss.

Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis

“…The clinical symptoms of COVID-19 patients vary widely. A signi cant proportion of COVID-19 patients have mild symptoms, such as fever, muscle ache, cough, shortness of breath and fatigue, and about half of patients are with no obvious symptoms [2,3]. However, some severe cases with severe pneumonia can develop into acute respiratory distress syndrome (ARDS), pulmonary edema, or multiple organ dysfunction syndrome(MODS), hence leading to a high mortality [4][5][6].…”

Recommended shielding against COVID-19 impacts physical activity levels in adults with cystic fibrosis

“…Severe acute respiratory syndrome – coronavirus-2 (SARS-CoV-2), has caused a pandemic of unknown example to date [1] . The World Health Organization described the disease caused by SARS-CoV-2 coronavirus disease 2019 (COVID-19) [2] .…”

Ribonucleocapsid assembly/packaging signals in the genomes of the coronaviruses SARS-CoV and SARS-CoV-2: detection, comparison and implications for therapeutic targeting

“…The pandemia is still continuing and the possibility of return of new disease waves is considered to be very high. The development of efficient medications and vaccines against coronaviruses needs the knowledge of main molecular mechanisms in the virus life cycle and virus–host interaction (Feng et al., 2020 ; Fung & Liu, 2019 ; Maier et al., 2015 ; Saxena, 2020 ; Xie & Chen, 2020 ; Ziebuhr, 2016 ). In this article, we will discuss a specific interaction between nucleocapsid (N) proteins and genomic ssRNA in the coronaviruses SARS-CoV and SARS-CoV-2.…”