2020
DOI: 10.3201/eid2607.200841
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Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease Patients

Abstract: a new coronavirus emerged in China and caused an acute respiratory disease now known as coronavirus disease 2019 (COVID-19) (1). The virus was identified to be a betacoronavirus related to severe acute respiratory syndrome coronavirus (SARS-CoV) and thus was named SARS-CoV-2 (2). In <2 decades, this virus is the third known coronavirus to cross the species barrier and cause severe respiratory infections in humans after SARS-CoV in 2003 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, yet wi… Show more

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Cited by 1,501 publications
(1,814 citation statements)
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References 15 publications
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“…Sera were tested for SARS-CoV-2 antibodies using a receptor binding domain (RBD) enzyme-linked immunosorbent assay (ELISA) as described previously, with some modifications 31 . Briefly, ELISA plates were coated overnight with either SARS-CoV-2 RBD.…”
Section: Methodsmentioning
confidence: 99%
“…Sera were tested for SARS-CoV-2 antibodies using a receptor binding domain (RBD) enzyme-linked immunosorbent assay (ELISA) as described previously, with some modifications 31 . Briefly, ELISA plates were coated overnight with either SARS-CoV-2 RBD.…”
Section: Methodsmentioning
confidence: 99%
“…Infection with SARS-CoV-2 elicits antibodies that bind to the virus [1][2][3][4][5][6]. But as is the case for all viruses [7][8][9][10], only some of these antibodies neutralize the virus's ability to enter cells [4,5,11,12].…”
Section: Introductionmentioning
confidence: 99%
“…But while there are now well-characterized and high-throughput methods (such as ELISA assays) to measure total antibody binding to SARS-CoV-2 or some of its key constituent proteins [2,6,26], quantifying neutralizing antibody activity is more difficult. The most biologically relevant method is to directly measure how antibodies or sera inhibit infection of cells by replicationcompetent SARS-CoV-2.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Defining these rates has been difficult due to various factors including f asymptomatic infection [57] and limits to molecular testing capacity. Several reports have confirmed that most patients with established SARS-CoV-2 infections mount serum antibody responses specific to viral proteins [810]. Because seroconversion may not occur for 1-3 weeks after symptom onset, antibody testing may have limited utility for diagnosis of acute infection.…”
Section: Introductionmentioning
confidence: 99%