Severe anaphylactic reaction to diclofenac

Jha, Atul; Bohra, Vijay; Behera, Vineet

doi:10.1016/j.mjafi.2014.08.015

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…Hypersensitivity to NSAIDs has a spectrum of manifestations from urticaria to severe anaphylaxis that can be life-threatening. These reactions are more frequent in patients with a known allergic reaction or autoimmune disorders who are to be considered a population at risk [2]. Diclofenac by itself was considered a safe drug and the experience in terms of patient-years is huge.…”

Section: Discussionmentioning

confidence: 99%

“…Both the pathways produce potent mediators of a multitude of immune-induced and inflammatory reactions. Any blockade of cyclo-oxygenase pathway (COP) shunts the metabolism towards the lipo-oxygenase pathway (LOP) and can potentially increase the side-effects of that pathway by augmented production and release of cysteinyl-leukotriene [1, 2].…”

Section: Introductionmentioning

confidence: 99%

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Severe Anaphylactic Reaction to Diclofenac during Intravenous Anesthesia for In Vitro Fertilization

Videnović¹,

Marković²,

Mladenović³

et al. 2019

Case Reports in Emergency Medicine

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We present a case of a severe anaphylactic reaction to diclofenac, administered as an intravenous infusion in a 45-year-old patient, during intravenous anesthesia for in vitro fertilization. During the preoperative clinical examination and obtaining of anamnestic data, the patient denied symptoms of allergies to medicines and other substances. The dominant clinical manifestations of anaphylactic reaction were: hypotension, tachycardia, angioedema, bronchospasm, and delayed awakening following anesthesia. No visible changes in the appearance of the skin, such as erythema or urticaria have been observed. Proper clinical observation and adequate intraoperative monitoring led to rapid diagnosis and significantly reduced the time interval from the onset of anaphylaxis to the beginning of treatment and reanimation procedures.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Severe Anaphylactic Reaction to Diclofenac during Intravenous Anesthesia for In Vitro Fertilization

Videnović¹,

Marković²,

Mladenović³

et al. 2019

Case Reports in Emergency Medicine

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show abstract

“…NSAID hypersensitivity can present itself in a variety of ways, from urticaria to life-threatening anaphylaxis. Patients with a history of allergic reactions or autoimmune illnesses are more likely to experience these reactions, making them a high-risk population [ 2 ]. Diclofenac was once thought to be a safe medicine, with a lot of patient-years under its belt.…”

Section: Discussionmentioning

confidence: 99%

“…Both pathways create powerful mediators of immunological and inflammatory responses. Any blockage of the cyclo-oxygenase pathway (COP) redirects metabolism to the lipo-oxygenase pathway (LOP), which may increase the system's negative effects by boosting cysteinyl-leukotriene synthesis and release [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Diclofenac induced anaphylaxis: A case report from Nepal

Bhattarai¹,

Shah

Uprety

et al. 2022

Annals of Medicine &Amp; Surgery

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“…Renal effects were also observed, as elevated creatinine levels were reported [ 62 , 63 ]. Further, in the case of a 35 year old patient, a severe life-threatening anaphylactic reaction to diclofenac was disclosed [ 64 ]. The side effects of diclofenac have been linked to its capacity to inhibit sodium and calcium channels in cardiac muscles [ 65 ] and change ROS levels [ 66 , 67 ].…”

Section: Diclofenac: Side Effects Adverse Drug Interactions and Thera...mentioning

confidence: 99%

Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases

Amanullah

Upadhyay

Dhiman

et al. 2022

Cancers

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Diclofenac is a highly prescribed non-steroidal anti-inflammatory drug (NSAID) that relieves inflammation, pain, fever, and aches, used at different doses depending on clinical conditions. This drug inhibits cyclooxygenase-1 and cyclooxygenase-2 enzymes, which are responsible for the generation of prostaglandin synthesis. To improve current diclofenac-based therapies, we require new molecular systematic therapeutic approaches to reduce complex multifactorial effects. However, the critical challenge that appears with diclofenac and other drugs of the same class is their side effects, such as signs of stomach injuries, kidney problems, cardiovascular issues, hepatic issues, and diarrhea. In this article, we discuss why defining diclofenac-based mechanisms, pharmacological features, and its medicinal properties are needed to direct future drug development against neurodegeneration and imperfect ageing and to improve cancer therapy. In addition, we describe various advance molecular mechanisms and fundamental aspects linked with diclofenac which can strengthen and enable the better designing of new derivatives of diclofenac to overcome critical challenges and improve their applications.

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Severe anaphylactic reaction to diclofenac

Cited by 6 publications

References 7 publications

Severe Anaphylactic Reaction to Diclofenac during Intravenous Anesthesia for In Vitro Fertilization

Severe Anaphylactic Reaction to Diclofenac during Intravenous Anesthesia for In Vitro Fertilization

Diclofenac induced anaphylaxis: A case report from Nepal

Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases

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