Severe Anaphylaxis after Albumin Infusion in a Patient with Ahaptoglobinemia

Detection of Hpdel among Thais, a deleted allele of the haptoglobin gene that causes congenital haptoglobin deficiency

“…The transfused blood products associated with these reactions were mainly PLT concentrates or FFP. In several cases, however, the infusion of HSA or RBCs, which contain a lower amount of haptoglobin, has also been associated with anaphylactic reactions 4,18,19 . The transfusion of haptoglobin‐depleted blood products is effective in avoiding such reactions 4,18‐20 …”

A novel method for the laboratory workup of anaphylactic transfusion reactions in haptoglobin‐deficient patients

“…Patients who are homozygous Hp del /Hp del are at significant risk of nonhemolytic transfusion reactions that are characterized by severe allergic symptoms, ultimately leading to anaphylaxis . These patients, who typically have a history of prior transfusions, are found to be haptoglobin deficient only after manifesting a severe nonhemolytic transfusion reaction, and they have IgG and usually IgE (Table S1, available as supporting information in the online version of this paper) anti‐haptoglobin antibodies in serum.…”

Detection of Hpdel in healthy individuals and cancer patients in Taiwan

“…Some case reports have examined congenital Hp deficiency among cases of severe anaphylactic transfusion reactions (22)(23)(24). All of these cases occurred in Japanese who were homozygous for a deleted allele of the Hp gene, Hp del .…”

“…All of these cases occurred in Japanese who were homozygous for a deleted allele of the Hp gene, Hp del . Alloimmunization may play a role in the development of anaphylactic nonhemolytic transfusion reactions due to the presence of both IgG and IgE class anti-haptoglobins, which have been noted in patient blood (22)(23)(24). Transfusion of Hp-depleted blood products should be considered in order to avoid such reactions (25).…”