2002
DOI: 10.1016/s0002-9343(02)01158-0
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Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents

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Cited by 81 publications
(42 citation statements)
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“…Hypoglycemias are rare, however, they are potentially life-threatening and have led to a number of fatalities [2]. While some of the hypoglycemic episodes have to be attributed to an interaction with sulfonylurea antidiabetic drugs [3][4][5], it is generally accepted that fluoroquinolones by themselves can induce hypoglycemias and concomitant sulfonylurea therapy is an independent risk factor [6].…”
Section: Introductionmentioning
confidence: 99%
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“…Hypoglycemias are rare, however, they are potentially life-threatening and have led to a number of fatalities [2]. While some of the hypoglycemic episodes have to be attributed to an interaction with sulfonylurea antidiabetic drugs [3][4][5], it is generally accepted that fluoroquinolones by themselves can induce hypoglycemias and concomitant sulfonylurea therapy is an independent risk factor [6].…”
Section: Introductionmentioning
confidence: 99%
“…Since in one large trial the risk of other fluoroquinolones was found not to be different from that of other antibacterial drugs it has been supposed that the induction of glucose abnormalities is not a class effect of fluoroquinolones [1]. Also, the fluoroquinolones norfloxacin and levofloxacin were found to be only weakly effective as K ATP channel blockers [10,11], but nevertheless there are case reports linking these compounds to severe and even lethal hypogycemias [13,14], which 4 raises the question as to whether there are unidentified triggering factors. Finally, gatifloxacin is also associated with the induction of hyperglycemic episodes in diabetic and non-diabetic patients [15,16].…”
Section: Introductionmentioning
confidence: 99%
“…Newer quinolones have improved in vitro activity against anaerobes, with trovafloxacin, moxifloxacin, and gatifloxacin having more potent activities than levofloxacin and ciprofloxacin (1, 3). Unfortunately, safety and toxicity concerns have limited the potential therapeutic usefulness of many of these agents (11,14,15,21). The present study was undertaken to investigate the in vitro activity of moxifloxacin against aerobic and anaerobic clinical isolates recently obtained from surgical patients with diabetic foot and intra-abdominal infections.…”
mentioning
confidence: 99%
“…The causal relationship between the observed reaction and the drug is often poorly documented and it sometimes takes years to link, with some degree of certainty, an adverse reaction to a particular drug [11,12]. The recent example of gatifloxacin-associated dysglycemic events [13,14] illustrates the time gap between the observation of an adverse event associated with the use of a particular drug and the confirmation of the problem being caused by this drug. For 3 years after the first publication reporting three cases of gatifloxacin-associated dysglycemic events, we either suspected gatifloxacin to be the culprit or simply wondered whether it was just an amplification phenomenon.…”
mentioning
confidence: 99%