2000
DOI: 10.1016/s0360-3016(99)00384-3
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Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas

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Cited by 209 publications
(162 citation statements)
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“…These experimental data are endorsed by more recent clinical findings in patients with cancer of the uterine cervix, and head and neck tumours undergoing radiotherapy (Hoeckel et al, 1996;Nordsmark et al, 1996). The intratumoral oxygen tension depends at least partly on the haemoglobin level of the blood (Vaupel and Hoeckel, 1998;Becker et al, 2000).…”
mentioning
confidence: 78%
“…These experimental data are endorsed by more recent clinical findings in patients with cancer of the uterine cervix, and head and neck tumours undergoing radiotherapy (Hoeckel et al, 1996;Nordsmark et al, 1996). The intratumoral oxygen tension depends at least partly on the haemoglobin level of the blood (Vaupel and Hoeckel, 1998;Becker et al, 2000).…”
mentioning
confidence: 78%
“…A Cochrane review based on 5 randomized Time since randomization ( controlled trials found strong indications that for patients with head and neck cancer, the addition of erythropoietin to radiotherapy negatively affects patient outcome in terms of loco-regional progression-free survival and OS (7). Suggested explanations for the lack of benefit of erythropoietin include presence of erythropoietin receptors on the tumor cell membranes stimulating tumor growth, and a decrease of tissue oxygenation because of increased viscosity when hemoglobin concentrations become too high (15)(16)(17).…”
Section: Discussionmentioning
confidence: 99%
“…It is generally assumed that this is primarily a consequence of the impaired tumor oxygenation resulting in a more aggressive and treatment resistant tumor phenotype (15,27). Indeed, clinical and preclinical studies do provide evidence for a correlation between hemoglobin level and tumor hypoxia measured by polarographic pO 2 electrodes (15,16,28,29). In particular, this association is present in patients with severe anemia [hemoglobin < 11.0 g/dL (<6.9 mmol/L)], whereas it is much weaker in patients with mild anemia or low normal hemoglobin levels.…”
Section: Mfs (%) Mfs (%)mentioning
confidence: 99%
“…There appears to be a correlation between anemia and increased hypoxia in patients with solid tumors. Becker et al 28 examined the tumor oxygenation status in 133 patients with head and neck carcinomas. Pretreatment Hb level Ͻ 11 g/dL was found to be a stronger predictor of poor tumor oxygenation than was tumor stage, tumor volume, or smoking status.…”
Section: Discussionmentioning
confidence: 99%