Severe atopic dermatitis associated with transient hypogammaglobulinemia of infancy

Transient Hypogammaglobulinemia and Severe Atopic Dermatitis: Open-label Treatment with Immunoglobulin in a Case Series

“…Two groups have been proposed within the THI population: those who remain asymptomatic, and those who are symptomatic and present with recurrent sinopulmonary infections. Although the incidence of concurrent atopy and THI remains unknown, [3][4][5] we propose a third group, in which atopic disease is prominent. As in our institution, Dorsey and Orange 6 describe 24 children with THI who had comorbid atopic characteristics: 42% with rhinitis, 38% with food allergy, 25% with AD, and 17% with urticarial rash.…”

“…11 Other investigators also showed improvement in their patients with AD after they received regular IVIG. 4,5,11 Another report, of five children, ages 7 to 12 months, who received IVIG (2 g/kg/dose) monthly for three doses had improved skin findings and significantly decreased inflammatory markers (ICAM-1, ELAM-1, ECP, and IL-2R). 12 Perhaps most compelling was the randomized, placebo-controlled study of 40 children with moderate-to-severe AD who were treated with higher doses of IVIG (2.0 g/kg IVIG), which showed that 3 months of therapy led to clinical improvement, although results declined after 6 months of treatment.…”

The impact of comorbidities on the severity of atopic dermatitis in children

“…AD is associated with several other comorbidities and underlying conditions. It is frequently reported in children with (transient) hypogammaglobulinemia of infancy, and the disease resolves with the normalization of immunoglobulin G (IgG) levels [9]. Children with AD were found to have a lower serum level of selenium and/or zinc than healthy children [10].…”

Transient hypogammaglobulinemia of infancy with no evidence of immunodeficiency other than atopic dermatitis: A case report and review of literature

“…However, reports describing THI-associated AD are limited. [2][3][4] We report a case of an infant with THI and severe AD, with no history of infections. Additionally, we review previous reports of THI-associated AD to clarify the diagnostic features of underlying THI in cases without history of infections.A 4-month-old boy was referred to our hospital with a 10 week history of severe eczematous lesions.…”

“…Literature regarding THI-associated AD is limited; as there have been documented only 13 cases involving the description of the clinical course of this condition (Table 1). [2][3][4] Past history of infections was described only in case 11. The rarity of reports This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.…”