Severe bronchopulmonary dysplasia increases risk for later neurological and motor sequelae in preterm survivors

Majnemer, Annette; Riley, Patricia; Shevell, Michael; Birnbaum, Rena; Greenstone, Harriet; Coates, Allan L.

doi:10.1111/j.1469-8749.2000.tb00025.x

Cited by 110 publications

(32 citation statements)

References 47 publications

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“…This finding is consistent with Majnemer et al 28 who found that at 10 years of age, 50% of children with BPD who had required home oxygen therapy had gross and fine motor skill deficits. The findings are also consistent with outcomes found in this cohort at 3 years of age, which indicated that history of BPD predicted poor motor skills beyond the effects of other medical and demographic factors.…”

Section: Discussionsupporting

confidence: 92%

Long-term sequelae of postnatal surfactant and corticosteroid therapies for BPD

et al. 2008

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Objective: This retrospective analysis assessed the relationship between medical treatment (postnatal steroids, surfactant) received neonatally and outcomes at 3 and 8 years using a longitudinal sample of children with bronchopulmonary dysplasia (BPD).Study Design: Four groups were formed retrospectively based on the type of neonatal medical treatment received: no drug intervention (n ¼ 37), surfactant only (n ¼ 29), postnatal steroids only (n ¼ 13) and combined surfactant and postnatal steroids (n ¼ 16). Groups were compared on neurological and medical outcomes.Result: Combined postnatal steroids and surfactant treatment was associated with more days on supplemental oxygen than no intervention or surfactant only. Surfactant replacement therapy alone was not associated with adverse consequences; however, postnatal steroid exposure appeared to be related. Conclusion:Although retrospective analyses make statements about causation impossible, the differential relationships of therapies with cognitive outcomes argues for careful monitoring of therapeutic agents with very low birth weight infants.

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Section: Discussionsupporting

confidence: 92%

Long-term sequelae of postnatal surfactant and corticosteroid therapies for BPD

et al. 2008

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“…Children involved in the research project compared to the control group would seem to be characterized by social orientation, collaboration, and interaction abilities, which give them the chance to be extrovert and to activate exchanges and build relationships, which can also assure them the development of the abilities that they lack. These data are consistent with some studies of the field (Davis et al 2007;Gray et al 2008;Manjemer et al 2000;Winchester et al 2009;Ketharanathan et al 2011;Perricone & Morales 2011a, b;Perricone et al 2012a, b). These are abilities that can support the social success and scholastic contextualization of preterm children.…”

Section: Discussionsupporting

confidence: 91%

School readiness of moderately preterm children at preschool age

2012

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The study investigates the preschool readiness of moderately preterm children and, in particular, the likely presence of learning disabilities at preschool age. Its theoretical model detects linguistic comprehension and expression; memory-related metacognition and cognition skills; orientation and motor coordination skills; premathematics and preliteracy ones. The research project involved an experimental group made up of 55 moderately preterm children (mean age062 months, mean gestational age034.6 weeks), without any clinical neonatal complications, and low birth weight (M02,100 g, SD0350 g); a control group made up of 55 full-term children without pre-and perinatal complications. The children's primary school reference teachers were given a questionnaire (Observative Questionnaire for Early Identification of Learning Disabilities), which was aimed at identifying any likely social and cognitive skill deficits at preschool age. The data, submitted to nonparametric univariate variance, show how scores of moderately preterm children in the metacognition [U (n1 en2055) 035, p00.04, r00.49] are statistically lower, other cognitive skills (memory, orientation, and visual-motor coordination) [U (n1en2055) 032, p00.02, r0 0.45], premathematics [U (n1en2055) 032, p00.02, r00.44], and the total score [U (n1en2055) 0 31, p00.02, r00.12]. Such data would seem to suggest the need for hypothesizing preventive training and educational paths as a prerequisite for the development of the school abilities.

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“…These risk factors include antenatal exposures, such as pregnancy-induced hypertension [6], gestational diabetes [7], and intrauterine inflammation [8][9][10], as well as male sex [11][12][13]. Putative perinatal and post-natal risk factors include early illness severity as measured by the Score of Neonatal Acute Physiology-Version II (SNAP-II) [14,15], infection [9,16,17], necrotizing enterocolitis [16,17], patent ductus arteriosus [18], chronic lung disease [18][19][20][21], and neonatal procedural pain [22]. We hypothesized that these ante-, peri-and postnatal comorbidities, rather than gestational age at birth, would predict poorer microstructural development in the corticospinal tract, as evidenced by higher mean diffusivity and lower fractional anisotropy in this motor pathway [23,24].…”

Section: Introductionmentioning

confidence: 99%

Score for Neonatal Acute Physiology–II and Neonatal Pain Predict Corticospinal Tract Development in Premature Newborns

Zwicker¹,

Grunau²,

Adams³

et al. 2013

Pediatric Neurology

116

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Premature infants are at risk for adverse motor outcomes, including cerebral palsy and developmental coordination disorder. The purpose of this study was to examine the relationship of ante-, peri-, and postnatal risk factors for abnormal development of the corticospinal tract, the major voluntary motor pathway, during the neonatal period. In a prospective cohort study, 126 premature neonates (24-32 weeks gestational age) underwent serial brain imaging near birth and at term-equivalent age. Using diffusion tensor tractography, mean diffusivity and fractional anisotropy of the corticospinal tract were measured to reflect microstructural development. Generalized estimating equation models examined associations of risk factors on corticospinal tract development.The perinatal risk factor of greater early illness severity [as measured by the Score for Neonatal Acute Physiology-II (SNAP-II)] was associated with a slower rise in fractional anisotropy of the corticospinal tract (p=0.02), even after correcting for gestational age at birth and postnatal risk factors (p=0.009). Consistent with previous findings, neonatal pain adjusted for morphine and postnatal infection were also associated with a slower rise in fractional anisotropy of the corticospinal tract (p=0.03 and 0.02 respectively). Lessening illness severity in the first hours of life might offer potential to improve motor pathway development in premature newborns.

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Severe bronchopulmonary dysplasia increases risk for later neurological and motor sequelae in preterm survivors

Cited by 110 publications

References 47 publications

Long-term sequelae of postnatal surfactant and corticosteroid therapies for BPD

Long-term sequelae of postnatal surfactant and corticosteroid therapies for BPD

School readiness of moderately preterm children at preschool age

Score for Neonatal Acute Physiology–II and Neonatal Pain Predict Corticospinal Tract Development in Premature Newborns

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